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Emergency Curative Resection of Colorectal Cancer

NCT ID: NCT04288284

Last Updated: 2020-02-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

215 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-01-31

Study Completion Date

2020-02-29

Brief Summary

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The feasibility and efficacy of emergency curative resection of complicated colorectal cancer is still controversial. This prospective study aim is to assess surgical and oncologic outcomes after emergency compared to elective curative resection of colorectal cancer

Detailed Description

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60 consecutive patients presented with complicated colorectal cancer managed by emergency surgery were included and compared to another 155 consecutive patients admitted during the same period with uncomplicated colorectal cancer managed by elective surgery. Both groups were compared regarding curative resection rate, early postoperative mortality and morbidity, 3-years tumor recurrence and survival rates.

Conditions

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Colorectal Cancer Oncologic Complications and Emergencies

Keywords

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Complicated colorectal cancer Curative resection Surgical and oncologic outcomes

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Emergency group

Patients presented to emergency by complicated colorectal cancer ( Obstruction, bleeding or perforation)

Curative resection of colorectal cancer

Intervention Type PROCEDURE

Elective group

Patients presented with uncomplicated colorectal cancer for resection treatment

Curative resection of colorectal cancer

Intervention Type PROCEDURE

Interventions

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Curative resection of colorectal cancer

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* All patients presented with Potentially operable colorectal cancer
* No clinical or radiological evidence of metastatic disease

Exclusion Criteria

* Patients received preoperative chemoradiation
* Patients with clinical or radiological evidence of metastatic disease
* Patients with intraoperative evidence of metastatic disease
* Patients with intraoperative evidence of irresectable disease
* Patients with incomplete follow up
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Alexandria

OTHER

Sponsor Role lead

Responsible Party

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Mohamed El Messiry

Ass. Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Mohamed Elmessiry, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Ass. Professor of Surgery

References

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Ghazi S, Berg E, Lindblom A, Lindforss U; Low-Risk Colorectal Cancer Study Group. Clinicopathological analysis of colorectal cancer: a comparison between emergency and elective surgical cases. World J Surg Oncol. 2013 Jun 11;11:133. doi: 10.1186/1477-7819-11-133.

Reference Type BACKGROUND
PMID: 23758762 (View on PubMed)

Biondo S, Marti-Rague J, Kreisler E, Pares D, Martin A, Navarro M, Pareja L, Jaurrieta E. A prospective study of outcomes of emergency and elective surgeries for complicated colonic cancer. Am J Surg. 2005 Apr;189(4):377-83. doi: 10.1016/j.amjsurg.2005.01.009.

Reference Type BACKGROUND
PMID: 15820446 (View on PubMed)

Kim J, Mittal R, Konyalian V, King J, Stamos MJ, Kumar RR. Outcome analysis of patients undergoing colorectal resection for emergent and elective indications. Am Surg. 2007 Oct;73(10):991-3.

Reference Type BACKGROUND
PMID: 17983065 (View on PubMed)

Other Identifiers

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0302761

Identifier Type: -

Identifier Source: org_study_id