Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
50 participants
OBSERVATIONAL
2020-10-31
2021-03-31
Brief Summary
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Certain eye conditions can predispose to issues with lens stability. If patients have stability issues with their natural lens- this would be termed as "phakodonesis". However, in patients who have had prior cataract surgery with implantation of an artificial lens (IOL)- this would be termed as "pseudophakodonesis". Eye conditions such as pseudoexfoliation or Marfan-syndrome can lead to unstable lens support- this can be detected if there are advanced stability issues.
However, small instability in the eye's would not be detected with present descriptive methods. The authors have designed a high-speed camera which is able to detect stability of the lens, especially during eye movements. The high-speed camera can detect variation in the change of light reflex from the lens and calculate the amount of lens instability/oscillation. The results (in normal eyes) of this high-speed camera has already been published in a peer-review journal. It is non-contact and measures lens movement. The test lasts less than 5 minutes.
Further research is required to assess the amount of lens oscillation (wobbling) in different eye populations - patients with previous cataract surgery (an artificial implant is used to replace the lens) or eye conditions (such as pseudoexfoliation, Marfan syndrome). The amount of lens stability has a role in the planning of further intraocular surgery - especially cataract extraction - however, at present, there is no approved quantitative measurement for this.
Participants will be recruited through Anglia Ruskin University (educational establishment), local community groups, and through Southend University Hospital eye clinics (NHS organisation). Participants' data will remain anonymous.
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Detailed Description
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Conditions
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Study Design
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COHORT
CROSS_SECTIONAL
Study Groups
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Conditions with predisposition to lens oscillations
Marfan Syndrome and Pseudoexfoliation
No interventions assigned to this group
Age-matched with normal axial lengths
No interventions assigned to this group
Age-matched with extreme axial lengths
No interventions assigned to this group
Intraocular lens
No interventions assigned to this group
Pre- and post- cataract surgery
No interventions assigned to this group
Normals
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Able to read and understand the English language
Exclusion Criteria
* Taking medications that cause miosis (pupil constriction)
* Patients with no light perception
* Patients unable to open their eyes e.g. due to significant ptosis
18 Years
ALL
Yes
Sponsors
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Mid and South Essex NHS Foundation Trust
OTHER
Anglia Ruskin University
OTHER
Responsible Party
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Locations
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Southend University Hospital NHS Foundation Trust
Southend-on-Sea, Essex, United Kingdom
Vision and Eye Research Institute (VERI)
Cambridge, , United Kingdom
Countries
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Facility Contacts
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Shahina Pardhan
Role: backup
Other Identifiers
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OSCCIL
Identifier Type: -
Identifier Source: org_study_id
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