Treatment of High and Very High riSk Dyslipidemic pAtients for the PreveNTion of CardiOvasculaR Events

NCT ID: NCT04271280

Last Updated: 2024-02-20

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 9559 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2020-03-17
• Study Completion Date: 2022-04-11

Brief Summary

High and Very High Risk cardiovascular patient journeys seems to vary from country to country, and current understanding of the process is incomplete. This real-life observational study which documents meaningful patient journey-related parameters can be expected to provide meaningful insight into the care process, country-by-country.

Detailed Description

Suffering from hypercholesterolemia is a major health concern in Europe. Appropriate medical treatment lowers low density lipoprotein cholesterol and reduces the incidence of clinical cardiovascular events. Despite the multiple available treatments, many patients remain inadequately treated or even untreated and some lipid-lowering drugs may be associated with an increase in events like side effects or increase in diabetes. As this is a non-interventional study, only data from routine clinical practice will be documented.

Conditions

Dyslipidemia; Cardiovascular Diseases; Hypercholesterolemia; Atherosclerotic Cardiovascular Disease

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: OTHER

Study Groups

High Risk and Very High Risk Dyslipidemic Participants

Participants are classified as High and Very High Risk (as assessed by the Framingham risk score for High Risk participants and the SMART score for Very High Risk participants) as well as if previously or newly diagnosed.

Non-interventional

Intervention Type: OTHER

This is a non-interventional study.

Interventions

Non-interventional

This is a non-interventional study.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Very High Risk and High Risk dyslipidemic patients requiring LMTs
• Not simultaneously participating in any interventional study
• Providing written informed consent for participation in the study (Informed consent form)
• Life expectancy > 1 year

Exclusion Criteria

• Not applicable; non-interventional study

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Contact for Clinical Trial Information

Role: STUDY_DIRECTOR

Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company

Locations

Krankenhaus St. Josef Braunau GmbH

Braunau am Inn, , Austria

LKH-Univ. Klinikum Graz

Graz, , Austria

Medizinische Universität Graz

Graz, , Austria

Medizinische Universität Innsbruck

Innsbruck, , Austria

KABEG Klinikum Klagenfurt am Wörthersee

Klagenfurt, , Austria

Konventhospital der Barmherzigen Brüder Linz

Linz, , Austria

Privatklinik Wehrle-Diakonissen

Salzburg, , Austria

Ordination Universitätsdozent Dr. Alexander Kober

Sankt Aegyd am Neuwalde, , Austria

Ordination Dr. med. univ. Evelyn Fließer-Görzer

Sankt Stefan, , Austria

Ordination Dr. Thomas Maca / Evangelische KH Wien

Vienna, , Austria

Ordination Dr. Thomas Maca / Evangelisches KH Wien

Vienna, , Austria

Krankenhaus Rudolfstiftung

Vienna, , Austria

Zentrum für Klinische Studien Dr. Hanusch GmbH

Vienna, , Austria

Allgemeines Krankenhaus der Stadt Wien

Vienna, , Austria

Ordination Dr. Reinhard Sock

Vienna, , Austria

Krankenhaus Hietzing mit neurologischem Zentrum Rosenhügel

Vienna, , Austria

Krankenhaus Nord - Klinik Floridsdorf

Vienna, , Austria

Internistische Facharztpraxis Frau Dr. Carmen Gelsinger

Zams, , Austria

ASZ

Aalst, , Belgium

Imeldaziekenhuis

Bonheiden, , Belgium

Clinique Saint-Luc

Bouge, , Belgium

AZ KLINA

Brasschaat, , Belgium

CHU Saint Pierre

Brussels, , Belgium

CHU Brugmann

Brussels, , Belgium

CUB Hospital Erasme

Brussels, , Belgium

UZ Brussel

Brussels, , Belgium

Cliniques de l'Europe

Brussels, , Belgium

Private practice

De Haan, , Belgium

Private practice

De Pinte, , Belgium

AZ Sint Blasius

Dendermonde, , Belgium

AZ Sint Lucas

Ghent, , Belgium

Universitair Ziekenhuis Gent

Ghent, , Belgium

Cabinet de médecine générale

Gribomont, , Belgium

CH Jolimont-Lobbes

Haine-Saint-Paul, , Belgium

CHR de Huy

Huy, , Belgium

Jan Yperman Hospital

Ieper, , Belgium

AZ Groeninge VZW

Kortrijk, , Belgium

CHC Liège

Liège, , Belgium

AZ Delta

Roeselare, , Belgium

AZ Glorieux

Ronse, , Belgium

Sint Trudo

Sint-Truiden, , Belgium

Private practice

Tienen, , Belgium

BVBA Dr CAPIAU

Wetteren, , Belgium

CHU UCL Namur

Yvoir, , Belgium

Z Sint Elisabeth Zottegem

Zottegem, , Belgium

Hjerteklinik Osterbro

Copenhagen, , Denmark

Amager Hospital

Copenhagen, , Denmark

Bispebjerg-Frederiksberg Hospital

Copenhagen, , Denmark

Bispebjerg/ Frederiksberg Hospital

Copenhagen, , Denmark

Sydvestjysk Sygehus Esbjerg

Esbjerg, , Denmark

Frederiksberg Hjerteklinik

Frederiksberg, , Denmark

Frederiksberg Hjerteklinik

Frederiksberg, , Denmark

Stroke center Rigshospitalet

Glostrup Municipality, , Denmark

Rigshospitalet (Copenhagen University Hospital) - Glostrup (Glostrup Hospital)

Glostrup Municipality, , Denmark

Gentofte Hospital

Hellerup, , Denmark

Kobenhavns Universitet - Holbaek Sygehus

Holbæk, , Denmark

Slagelse sygehus

Slagelse, , Denmark

Mehiläinen Leppävaara

Espoo, , Finland

Geri-Med Oy

Helsinki, , Finland

Pihlajalinna Dextra

Helsinki, , Finland

Pihlajalinna (Site 04-007)

Joensuu, , Finland

Pihlajalinna (Site 04-022)

Joensuu, , Finland

StudyCor Oy

Jyväskylä, , Finland

Terveystalo Kalajoki

Kalajoki, , Finland

Aava Kerava Medical Center

Kerava, , Finland

Terveystalo Kokkola

Kokkola, , Finland

Mehiläinen Kuopio

Kuopio, , Finland

Lappeenrannan Työterveys - Site 4024

Lappeenranta, , Finland

Lappeenrannan Työterveys - Site 4025

Lappeenranta, , Finland

Terveystalo

Loimaa, , Finland

Oulu University Hospital

Oulu, , Finland

Satasairaala

Pori, , Finland

Sastamalan seudun sosiaali- ja terveyspalvelut

Sastamala, , Finland

Seinäjoki Central Hospital

Seinäjoki, , Finland

Terveystalo Tampere

Tampere, , Finland

Tampere University Hospital

Tampere, , Finland

Mehiläinen Turku Kauppiaskatu

Turku, , Finland

Turku University Hospital

Turku, , Finland

Turku University Hospital

Turku, , Finland

Terveystalo Myyrmäki (Site 04015)

Vantaa, , Finland

Terveystalo Myyrmäki (Site 04017)

Vantaa, , Finland

Finla Työterveys Vantaa

Vantaa, , Finland

4 Rue Larrey

Angers, , France

Cabinet médical Louis Blanc

Anzin, , France

Clinique d'Argonay

Argonay, , France

Hôpital Henri Duffaut

Avignon, , France

Centre de Cardiologie et d'exploration de la Côte Basque

Bayonne, , France

151 rue Georges Clémenceau

Breteuil, , France

4 Rue du Capitaine Drillien

Chalon-sur-Saône, , France

Centre Hospitalier de Chateauroux

Châteauroux, , France

CH Compiègne

Compiègne, , France

Centre Hopsitalier Alpes Leman, 552 Route de Findrol

Contamine-sur-Arve, , France

619 Rue de Saint Vaast

Flesselles, , France

CHU Grenoble

Grenoble, , France

2 Boulevard Victor Hugo

Istres, , France

2 Rue du Dr Schweitzer

La Rochelle, , France

Hôpital Louis Pasteur

Le Coudray, , France

222 Avenue du Mont Gaillard

Le Havre, , France

Hôpital Marie Lannelongue

Le Plessis-Robinson, , France

Institut Cœur Poumons, Boulevard du Pr Leclercq

Lille, , France

Centre Hospitalier de Lisieux, 4 Rue Roger Aini

Lisieux, , France

Centre Hospitalier La Timone

Marseille, , France

Clinique de Meudon

Meudon-la-Forêt, , France

Clinique du Pont de Chaume

Montauban, , France

Clinique du Millénaire

Montpellier, , France

Centre Hospitalier Universitaire de Nantes

Nantes, , France

Hôpital Guillaume et René Laennec

Nantes, , France

Centre Hospitalier de Nice

Nice, , France

CHU Carémeau

Nîmes, , France

Cabinet médical du docteur Cohen

Paris, , France

Cabinet de cardiologie

Paris, , France

Hôpital Pitié Salpétrière

Paris, , France

Centre Hospitalier de Pau

Pau, , France

Clinique Sant Hilaire

Rouen, , France

82 Avenue de Pontaillac

Royan, , France

Hôpital Sainte Musse

Toulon, , France

Centre Hospitalier Toulouse

Toulouse, , France

Hôpital Guy Chatillez

Tourcoing, , France

Downtown Clinic Aachen

Aachen, , Germany

Kardiologische Praxis Aachen

Aachen, , Germany

Praxis Delonge

Aachen, , Germany

Kliniken an der Paar - Krankenhaus Aichach

Aichach, , Germany

Oberpfalz Research GbR

Amberg, , Germany

MVZ Aue

Aue, , Germany

Kardiologische Praxis

Bad Elster, , Germany

Kardiologische Praxis

Bad Homburg, , Germany

Universitäts-Herz-Zentrum Freiburg-Bad Krozingen

Bad Krozingen, , Germany

Kerckhoff-Klinik Forschungsgesellschaft mbH

Bad Nauheim, , Germany

Herz - u. Diabeteszentrum NRW

Bad Oeynhausen, , Germany

Praxis am Landratspark

Bad Segeberg, , Germany

Gemeinschaftspraxis für Herz und Lunge

Bamberg, , Germany

Kardiologische Praxis

Bechhofen, , Germany

Diabetespraxis Prenzlauer Allee

Berlin, , Germany

Praxis Rankestraße

Berlin, , Germany

MVZ Dres. Ramdohr - Praxis für Cardiovascular und Ultraschalldiagnostik

Berlin, , Germany

Praxis Dr. Matthias Claus

Berlin, , Germany

Kardiologische Facharztpraxis Dr. Anne Winkelmann

Berlin, , Germany

Charité Campus Virchow

Berlin, , Germany

Vivantes Humboldt-Klinikum

Berlin, , Germany

Vivantes Klinikum Spandau

Berlin, , Germany

Marienhaus-Klinikum Eifel Bitburg

Bitburg, , Germany

Städtisches Klinikum Brandenburg

Brandenburg, , Germany

Kardiologie an der Paulikirche

Braunschweig, , Germany

Kardiologie im Friedrichspalast Bruchsal

Bruchsal, , Germany

MediClin Reha-Zentrum Spreewald

Burg, , Germany

MVZ am Küchwald

Chemnitz, , Germany

Praxis Dipl.med Schermaul

Chemnitz, , Germany

Kardiologische Praxis

Chemnitz, , Germany

MVZ Polymed

Chemnitz, , Germany

St. Josefs-Hospital Cloppenburg

Cloppenburg, , Germany

Klinikum Coburg GmbH

Coburg, , Germany

MVZ Gesundes Herz

Cologne, , Germany

Praxis Dr. Menzel

Dessau, , Germany

Klinikum Lippe GmbH

Detmold, , Germany

Kardiologische Gemeinschaftspraxis

Dortmund, , Germany

Sankt-Johannes-Hospital

Dortmund, , Germany

Kardiologische Gemeinschaftspraxis Dres. Wetzel/Willgeroth

Dortmund, , Germany

Zentrum für klinische Prüfungen in der Facharztzentrum Dresden-Neustadt GbR

Dresden, , Germany

Praxis Dr. Methfessel

Dresden, , Germany

Hausärztlich-Kardiologisches MVZ "Am Felsenkeller" GmbH

Dresden, , Germany

Studienzentrum Dr. Faulmann

Dresden, , Germany

Dres. Günther/Kolschmann

Dresden, , Germany

Universitätsklinikum Carl Gustav Carus

Dresden, , Germany

Praxis Dres. Jänsch/Varnai

Dresden, , Germany

Praxis Dipl. - Med. Petra Herrmann - Fachärztin für Innere Medizin

Eisenach, , Germany

Kardiologische Praxis

Elsterwerda, , Germany

Elisabeth Krankenhaus Essen

Essen, , Germany

Universitätsklinikum Essen

Essen, , Germany

Medizentrum Essen Borbeck

Essen, , Germany

Klinikum Frankfurt Hoechst GmbH

Frankfurt, , Germany

MVZ Altstadt-Carree Fulda GmbH

Fulda, , Germany

Evangelisches Krankenhaus Gelsenkirchen

Gelsenkirchen, , Germany

Kardiologische Praxis

Gera, , Germany

Kardiologische Praxis

Gotha, , Germany

Praxis für Gefäßmedizin

Görlitz, , Germany

Universitätsmedizin Göttingen

Göttingen, , Germany

Praxis für Herzkreislauferkrankungen Greiz

Greiz, , Germany

Evangelisches Krankenhaus Hagen-Haspe

Hagen, , Germany

Gemeinschaftspraxis Dres. J. Hintze und M. Grundner

Hainstadt, , Germany

Cardiologicum Hamburg-Wandsbek

Hamburg, , Germany

Kardiologie am Tibarg

Hamburg, , Germany

MVZ Prof. Detlef Mathey, Prof. Schofer GmbH

Hamburg, , Germany

Kardiologische Praxis

Hanover, , Germany

Kardiologische Praxis

Haßloch, , Germany

Kardiologische Schwerpunktpraxis

Heidelberg, , Germany

Praxis für Angiologie und Hämatologie

Heidelberg, , Germany

Uniklinikum Heidelberg

Heidelberg, , Germany

Praxis

Homburg, , Germany

Kardiologie Oberschwaben - Bodensee Herz- und Gefäßpraxis

Isny, , Germany

Kardiologische Praxis

Jena, , Germany

Kardiopraxis Schirmer

Kaiserslautern, , Germany

Kardiologie/Internistenteam Kamen

Kamen, , Germany

SRH Klinikum Karlsbad-Langensteinbach

Karlsbach, , Germany

B. Braun Ambulantes Herzzentrum MVZ GmbH

Kassel, , Germany

CC Cleve-Studiencenter

Kleve, , Germany

Studienzentrum der Inneren Medizin I & II am Klinikum Konstanz

Konstanz, , Germany

Praxis für Innere Medizin / Kardiologie - Dr. med. E. Persicke / Dr. med. O. Scheuermann

Kornwestheim, , Germany

Kardiologische Gemeinschaftspraxis

Leipzig, , Germany

MediClin MVZ Leipzig

Leipzig, , Germany

Praxis für Gefäßerkrankungen und Gerinnungsstörungen Leipzig

Leipzig, , Germany

Gemeinschaftspraxis Dr. Täschner/Dr. Bonigut

Leipzig, , Germany

MVZ Stoffwechselmedizin Leipzig

Leipzig, , Germany

Universitätsklinikum Leipzig

Leipzig, , Germany

Kardiologische Fachpraxis

Lengerich, , Germany

Praxis Dr. med. Ilka Simon-Wagner

Lichtenfels, , Germany

St. Vincenz-Krankenhaus

Limburg, , Germany

Gemeinschaftspraxis Dr. Jens Biesenbaum und Dr. Uwe Gerbaulet

Löhne, , Germany

Kardiologische Praxis Lohne

Löhne, , Germany

Cardio Centrum Ludwigsburg-Bietigheim

Ludwigsburg, , Germany

Kardiologische Praxisklinik Ludwigshafen

Ludwigshafen, , Germany

Klinikum Lüdenscheid

Lüdenscheid, , Germany

Dres. Erdmann/Schütz/Sicken

Lünen, , Germany

St.Vincenz - u. Elisabeth-Hospital

Mainz, , Germany

Universitätsklinikum Mainz Site 6186

Mainz, , Germany

Universitätsklinikum Mainz Site 6187

Mainz, , Germany

zero Praxen Mannheim

Mannheim, , Germany

Universitätsklinikum Mannheim

Mannheim, , Germany

Kardiologische Praxis

Markkleeberg, , Germany

Praxis Dr. Ben-Chur

Meiningen, , Germany

Kardiologie-Praxis

Moers, , Germany

Gemeinschaftspraxis Dr. med. Martin Prohaska und Dr. med. Felix Schulte

Mühldorf, , Germany

Herzquartier Mühlheim, Kardiologische Gemeinschaftspraxis Dres. med. A. Krapivsky & P. Kekes

Mühlheim, , Germany

Zentrum für Diabetes und Gefäßerkrankungen Münster

Münster, , Germany

Praxis für Innere Medizin

Münster, , Germany

Universitätsklinikum Münster

Münster, , Germany

Praxis für Innere Medizin und Angiologie

Nordhausen, , Germany

Kardiologische Praxis Northeim

Northeim, , Germany

Gemeinschaftspraxis Drs. Haggenmiller/Jeserich Kardiologie-Angiologie-Innere Medizin

Nuremberg, , Germany

Kardiologie am Weißen Turm

Nuremberg, , Germany

St. Vincenz-Krankenhaus GmbH

Paderborn, , Germany

Kardiologische Praxis

Panitzsch, , Germany

Kardiologische Praxis Papenburg (Site 6097)

Papenburg, , Germany

Kardiologische Praxis Papenburg (Site 6098)

Papenburg, , Germany

Kardiologische Praxis

Pirmasens, , Germany

Cardiologicum Dresden/Pirna

Pirna, , Germany

Kardiologie Potsdam

Potsdam, , Germany

Kardiologische Gemeinschaftspraxis Potsdam

Potsdam, , Germany

Paracelsus-Harz-Klinik Bad Suderode

Quedlinburg, , Germany

Drs. Bauer/Buresch/Kösler

Regensburg, , Germany

Gemeinschaftspraxis Herz Riesa

Riesa, , Germany

Universitätsmedizin Rostock

Rostock, , Germany

Zentrum für Prävention und Rehabilitation

Siegen, , Germany

Kardiologische Praxis

Stahnsdorf, , Germany

Praxis Dr. Birkenhagen

Stollberg, , Germany

Drs. Knoebel @ Partner

Straubing, , Germany

Praxis Dr. Michael Rother

Strausberg, , Germany

Diabetologische Schwerpunktpraxis

Trier, , Germany

Krankenhaus der Barmherzigen Brüder Trier

Trier, , Germany

Studienzentrum der Herzklinik Ulm GbR

Ulm, , Germany

Praxis Dr. Sabine Hansen

Unterwellenborn, , Germany

Praxis für Prävention und Therapie

Villingen-Schwenningen, , Germany

SHG Klinik Völklingen

Völklingen, , Germany

GRN Klinik Weinheim

Weinheim, , Germany

Forschungszentrum-Ruhr KliFoCenter GmbH

Witten, , Germany

Klinikum Worms

Worms, , Germany

Praxis Dr. Woitek

Wurzen, , Germany

Praxis T. Schwarz

Zwenkau, , Germany

Beaumont Hospital

Beaumont, Dublin, Ireland

Tramore Medical Clinic

Tramore, Waterford, Ireland

Cork University Hospital

Cork, , Ireland

Mater Private Hospital

Dublin, , Ireland

St. James Hospital

Dublin, , Ireland

Beacon Hospital

Dublin, , Ireland

Turloughmore Health Centre

Galway, , Ireland

Ospedale Civile SS. Annunziata (MEDICINA INTERNA- DIPARTIMENTO DI MEDICINA E SCIENZE DELL'INVECCHIAMENTO)

Chieti, Abruzzo, Italy

Ente Ecclesiastico Ospedale Generale Regionale "F.Miulli"

Bari, Apulia, Italy

A.O.U. Consorziale - Policlinico Bari (Dipartimento di Medicina Interna)

Bari, Apulia, Italy

A.O.U. Consorziale - Policlinico Bari

Bari, Apulia, Italy

A.O.U. Ospedali Riuniti

Foggia, Apulia, Italy

Presidio Ospedaliero Vito Fazzi

Lecce, Apulia, Italy

Azienda Ospedaliera Universitaria Mater Domini - Site 8042

Catanzaro, Calabria, Italy

Azienda Ospedaliera Universitaria Mater Domini - Site 8053

Catanzaro, Calabria, Italy

Azienda Ospedaliera Universitaria Mater Domini - Site 8059

Catanzaro, Calabria, Italy

Ospedale G. Jazzolino

Vibo Valentia, Calabria, Italy

A.O. San Giuseppe Moscati (U.O.C. Cardiologia/UTIC)

Avellino, Campania, Italy

A.O. San Giuseppe Moscati

Avellino, Campania, Italy

A.O.R.N. San Pio - P.O. RUMMO

Benevento, Campania, Italy

Azienda Ospedaliera di Rilievo Nazionale(A.O.R.N.) "Sant'Anna e San Sebastiano" di Caserta

Caserta, Campania, Italy

Ospedale Civile Santa Maria Incoronata dell'Olmo

Cava de' Tirreni, Campania, Italy

A.O.R.N. Cardarelli

Napoli, Campania, Italy

A.O.R.N. Ospedale dei Colli

Napoli, Campania, Italy

A.O.U. FEDERICO II (U.O.C. Diabetologia)

Napoli, Campania, Italy

A.O.U. Federico II

Napoli, Campania, Italy

A.O.U. "San Giovanni di Dio e Ruggi d'Aragona"

Salerno, Campania, Italy

Ospedale Civile San Rocco

Sessa Aurunca, Campania, Italy

Ospedale di Bentivoglio

Bentivoglio, Emilia-Romagna, Italy

Ospedale Maggiore di Bologna

Bologna, Emilia-Romagna, Italy

A.O.U di Bologna-Policlinico S.Orsola-Malpighi (U.O. Medicina Interna)

Bologna, Emilia-Romagna, Italy

Policlinico Sant'Orsola-Malpighi (U.O. Cardiologia)

Bologna, Emilia-Romagna, Italy

Ospedale di Carpi

Carpi, Emilia-Romagna, Italy

Arcispedale Sant'Anna Ferrara (U.O. Cardiologia)

Ferrara, Emilia-Romagna, Italy

Azienda Ospedaliera-Universitaria S. Anna di Ferrara (Dipartimento medico)

Ferrara, Emilia-Romagna, Italy

A.O.U. Policlinico di Modena

Modena, Emilia-Romagna, Italy

Ospedale Civile di Baggiovara- AOU di Modena

Modena, Emilia-Romagna, Italy

Ospedale Unico della Valtidone

Piacenza, Emilia-Romagna, Italy

Ospedale Guglielmo da Saliceto

Piacenza, Emilia-Romagna, Italy

Arcispedale Santa Maria Nuova - Azienda USL/IRCCS Reggio Emilia

Reggio Emilia, Emilia-Romagna, Italy

Presidio Ospedaliero "Santa Maria della Misericordia" di Udine

Udine, Friuli, Italy

ASL Roma 6 - Ospedali Riuniti Anzio - Nettuno

Anzio, Lazio, Italy

Ospedale dei Castelli - ASL Roma 6

Rome, Lazio, Italy

Policlinico Universitario Campus Bio-Medico

Rome, Lazio, Italy

Policlinico Umberto I

Rome, Lazio, Italy

Fondazione Policlinico Universitario A. Gemelli IRCCS

Rome, Lazio, Italy

Ospedale Policlinico Casilino

Rome, Lazio, Italy

Azienda Ospedaliera San Giovanni Addolorata

Rome, Lazio, Italy

Azienda Ospedaliera Papa Giovanni XXIII

Bergamo, Lombardy, Italy

ASST Spedali Civili P.O di Brescia

Brescia, Lombardy, Italy

Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (U.O Medicina Generale 2)

Brescia, Lombardy, Italy

Fondazione Poliambulanza Istituto Ospedaliero - Brescia

Brescia, Lombardy, Italy

IRCCS Multimedica

Milan, Lombardy, Italy

Fondazione IRCSS Ca' Granda Ospedale Maggiore Policlinico

Milan, Lombardy, Italy

Centro Cardiologico Monzino - IRCCS (Unità Prevenzione dell'Aterosclerosi)

Milan, Lombardy, Italy

Centro Cardiologico Monzino - IRCCS

Milan, Lombardy, Italy

Istituto Clinico Sant'Ambrogio

Milan, Lombardy, Italy

IRCCS Istituto Ortopedico Galeazzi

Milan, Lombardy, Italy

Grande Ospedale Metropolitano di Niguarda

Milan, Lombardy, Italy

Presidio ospedaliero Cardinal Massaia - A.S.L. AT (SOC Diabetologia e Malattie Metaboliche)

Asti, Piedmont, Italy

Ospedale Regina Montis Regalis

Mondovì, Piedmont, Italy

Ospedale degli Infermi di Rivoli

Turin, Piedmont, Italy

A.O.U. Città della Salute e della Scienza di Torino

Turin, Piedmont, Italy

Ospedale dei Castelli

Verbania, Piedmont, Italy

Ospedale Civile SS Annunziata (Dipartimento di Medicina Clinica e Sperimentale)

Sassari, Sardinia, Italy

Ospedale Cannizzaro

Catania, Sicily, Italy

A.O.U. Policlinico "G. Martino" (U.O. Cardiologia)

Messina, Sicily, Italy

Ospedale Buccheri La Ferla

Palermo, Sicily, Italy

Triolo Zancle Hospital

Palermo, Sicily, Italy

Ospedale Giovanni Paolo II

Ragusa, Sicily, Italy

INRCA -Ospedale U. Sestilli di Ancona

Ancona, The Marches, Italy

Ospedali Riuniti "Umberto I - Lancisi - Salesi

Ancona, The Marches, Italy

Ospedale Macerata

Macerata, The Marches, Italy

Ospedale di Bolzano (U.O. Cardiologia e Prove Funzionali)

Bolzano, Trentino-Alto Adige, Italy

Ospedale San Giuseppe

Empoli, Tuscany, Italy

A.O.U. Careggi (S.O.D. Malattie Aterotrombotiche) - Site 8020

Florence, Tuscany, Italy

A.O.U. Careggi - Site 8041

Florence, Tuscany, Italy

A.O.U. Careggi - Site 8093

Florence, Tuscany, Italy

Ospedale S. Andrea - Usl Toscana Sud Est

Massa Marittima, Tuscany, Italy

Ospedale SS Cosma e Damiano di Pescia - Azienda Usl Toscana centro

Pescia, Tuscany, Italy

Università di Pisa

Pisa, Tuscany, Italy

Fondazione Toscana Gabriele Monasterio

Pisa, Tuscany, Italy

Ospedale Cisanello - A.U.O.P. Azienda Ospedaliera Universitaria Pisana

Pisa, Tuscany, Italy

Ospedale di Santo Stefano di Prato - Azienda Usl Toscana centro (UO di Cardiologia)

Prato, Tuscany, Italy

Ospedale Santo Stefano di Prato - Azienda Usl Toscana Centro

Prato, Tuscany, Italy

Azienda Ospedaliero-Universitaria Senese Dipartimento Delle Scienze Mediche U.O.C. Medicina Interna e della Complessità

Siena, Tuscany, Italy

Ospedale Le Scotte

Siena, Tuscany, Italy

USL Umbria I

Perugia, Umbria, Italy

A.O. Santa Maria della Misericordia

Perugia, Umbria, Italy

Ospedale di Arzignano

Arzignano, Veneto, Italy

Ospedale Mater Salutis

Legnago, Veneto, Italy

Presidio Ospedaliero di Mirano - ULSS 3 Serenissima

Mirano, Veneto, Italy

Jeroen Bosch Hospital

's-Hertogenbosch, , Netherlands

Ziekenhuis Groep Twente (ZGT)

Almelo, , Netherlands

ZiekenhuisGroepTwente, Zilvermeeuw 1

Almelo, , Netherlands

Meander Medical Center

Amersfoort, , Netherlands

Meander Medisch Centrum, Maatweg 3

Amersfoort, , Netherlands

Bovenij Zekenhuis

Amsterdam, , Netherlands

Albert Schweitzerlaan 31

Apeldoorn, , Netherlands

Gelre Ziekenhuis

Apeldoorn, , Netherlands

Tergooi

Blaricum, , Netherlands

Ijsselland Ziekenhuis, Prins Constanijnweg 2

Capelle aan den IJssel, , Netherlands

IJsselland Ziekenhuis

Capelle aan den IJssel, , Netherlands

Reinier de Graafweg 5

Delft, , Netherlands

Nico Bolkesteinlaan 75

Deventer, , Netherlands

Van Weel Bethesda

Dirksland, , Netherlands

Slingeland

Doetinchem, , Netherlands

Gelderse Vallei

Ede, , Netherlands

Medisch Spectrum Twente

Enschede, , Netherlands

Admiraal de Ruijten Ziekenhuis

Goes, , Netherlands

Groene Hart Gouda

Gouda, , Netherlands

Boerhaavelaan 22

Haarlem, , Netherlands

Ropcke Zweers hospital, Jan Weitkamplaan 4-a

Hardenberg, , Netherlands

Saxenburgh Medisch Centrum

Hardenberg, , Netherlands

Ziekenhuis St Jansdal

Harderwijk, , Netherlands

Dr G.H. Amshoffweg 1

Hoogeveen, , Netherlands

Treant Zorggroep

Hoogeveen, , Netherlands

LUMC

Leiden, , Netherlands

Ikazai Ziekenhuis

Rotterdam, , Netherlands

Els Borst

The Hague, , Netherlands

Rivierenland ziekenhuis Tiel

Tiel, , Netherlands

ETZ

Tilburg, , Netherlands

Nistelrodeseweg 10

Uden, , Netherlands

University Medical Center Utrecht

Utrecht, , Netherlands

Diakonessenhuis Utrecht

Utrecht, , Netherlands

Maxima Medisch Centrum

Veldhoven, , Netherlands

Zaans Medisch Centrum

Zaandam, , Netherlands

Instituto do Coração

Carnaxide, , Portugal

Centro Hospitalar Universitario do Algarve

Faro, , Portugal

Associação Protetora de Diabéticos de Portugal

Lisbon, , Portugal

Hospital Egas Moniz (CHLO)

Lisbon, , Portugal

Hospital Lusíadas de Lisboa, Lisboa

Lisbon, , Portugal

Centro Hospitalar Lisboa Norte - Site 10005

Lisbon, , Portugal

Centro Hospitalar Lisboa Norte - Site 10006

Lisbon, , Portugal

Clínica Cuida Mais

Mangualde, , Portugal

Centro Hospitalar Universitário São João (CHUSJ)

Porto, , Portugal

Instituto CUF Porto

Porto, , Portugal

Centro Hospitalar de Entre Douro e Vouga

Santa Maria da Feira, , Portugal

Hospital de Alta Resolución de Sierra Norte

Constantina, Andalusia, Spain

H. Reina Sofia

Córdoba, Andalusia, Spain

Hospital de Alta Resolución de Ecija

Écija, Andalusia, Spain

H Juan Ramón Jiménez de Huelva

Huelva, Andalusia, Spain

H. Infanta Elena

Huelva, Andalusia, Spain

Centro Médico Puerto

Jerez de la Frontera, Andalusia, Spain

HG. Univ. De Jérez

Jerez de la Frontera, Andalusia, Spain

Hospital de Alta Resolución de Lebrija

Lebrija, Andalusia, Spain

H Carlos Haya

Málaga, Andalusia, Spain

H. Univ. Virgen Macarena

Seville, Andalusia, Spain

H. San Agustín

Seville, Andalusia, Spain

H. Alta Resolución de Utrera

Utrera, Andalusia, Spain

Hospital de Alta Resolución de La Janda

Vejer de la Frontera, Andalusia, Spain

H. San Eloy

Barakaldo, Basque Country, Spain

H. Univ. Basurto

Bilbao, Basque Country, Spain

H. Univ. de Basurto

Bilbao, Basque Country, Spain

Clinica Privada Orotava

La Orotava, Canary Islands, Spain

C S Colloto

Colloto, Castille and León, Spain

H Universitario De León

León, Castille and León, Spain

H Clínico de Salamanca

León, Castille and León, Spain

C S de la Alamedilla

Salamanca, Castille and León, Spain

H. General de Segovia

Segovia, Castille and León, Spain

Complejo Asistencial de Zamora

Zamora, Castille and León, Spain

H. Clinic i Provincial de Barcelona

Barcelona, Catalonia, Spain

H de la Santa Creu i Sant Pau

Barcelona, Catalonia, Spain

H. Universitari Bellvitge

L'Hospitalet de Llobregat, Catalonia, Spain

Complejo Hospitalario Universitario A Coruña

A Coruña, Galicia, Spain

Complejo Hospitalario Univ. El Ferrol

Ferrol, Galicia, Spain

Complejo Hospitalario de Ourense

Ourense, Galicia, Spain

H. Clínico Univ. Santiago de Compostela

Santiago de Compostela, Galicia, Spain

Hospital Principe de Asturias

Alcalá de Henares, Madrid, Spain

H. Universitario Fuenlabrada

Fuenlabrada, Madrid, Spain

H. Univ. Infanta Sofía

San Sebastián de los Reyes, Madrid, Spain

H. Costa del Sol

Marbella, Málaga, Spain

H Universitario Central de Asturias

Oviedo, Principality of Asturias, Spain

Hospital Universitario Fundación Alcorcón

Alcorcón, , Spain

H. del Mar Site 11041

Barcelona, , Spain

H. del Mar Site 11065

Barcelona, , Spain

H. Univ. Basurto

Bilbao, , Spain

Centro de Salud Colloto

Colloto, , Spain

Hospital Univ. Getafe

Getafe, , Spain

Hospital de Jerez

Jerez de la Frontera, , Spain

Hospital Universitari de Bellvitge

L'Hospitalet de Llobregat, , Spain

Hospital Universitario de la Princesa Site 11054

Madrid, , Spain

Hospital Universitario de la Princesa Site 11062

Madrid, , Spain

Hospital Universitario de la Princesa Site 11075

Madrid, , Spain

H Gregorio Marañon

Madrid, , Spain

Hospital Universitario Gregorio Marañon

Madrid, , Spain

Clinica Universitaria de Navarra

Madrid, , Spain

Clínica Universitaria de Navarra

Madrid, , Spain

Fundación Jiménez Díaz

Madrid, , Spain

H. Univ. Clínico San Carlos

Madrid, , Spain

H. Univ. La Paz-Carlos III

Madrid, , Spain

H. Universitario La Paz-Carlos III

Madrid, , Spain

Hospital La Paz-Carlos III

Madrid, , Spain

H. Univ. Ramón y Cajal

Madrid, , Spain

Fundación Jiménez Díaz

Madrid, , Spain

H. Universitario 12 de octubre

Madrid, , Spain

H. Clínico Virgen de la Arrixaca

Murcia, , Spain

Complejo Hospitalario Universitario de Ourense (CHOU) Site 11003

Ourense, , Spain

Complejo Hospitalario Universitario de Ourense (CHOU) Site 11052

Ourense, , Spain

H. San Joan de Reus

Reus, , Spain

Hospital Parc Tauli

Sabadell, , Spain

Hospital Clínico de Salamanca

Salamanca, , Spain

Hospital Universitario Infanta Sofía

San Sebastián de los Reyes, , Spain

Hospital de Sant Joan Despí Moisès Broggi

Sant Joan Despí, , Spain

Hospital Universitario Marqués de Valdecilla

Santander, , Spain

Hospital General de Segovia

Segovia, , Spain

Hospital Universitario Virgen de la Macarena

Seville, , Spain

Hospital Sant Pau i Santa Tecla

Tarragona, , Spain

Hospital HM de Torrelodones

Torrelodones, , Spain

Centro de Salud Fuentes Norte

Zaragoza, , Spain

Falu Lasarett, Diab/Endo-mottagning

Falun, , Sweden

Sahlgrenska University Hospital

Gothenburg, , Sweden

Östra Sahlgrenska Universitetssjukhuset - Ostra Sjukhuse

Gothenburg, , Sweden

Värmdö Vårdcentral

Gustavsberg, , Sweden

Öbackakliniken

Härnösand, , Sweden

Länssjukhuset Ryhov

Jönköping, , Sweden

Capio Citykliniken

Lund, , Sweden

Skåne University Hospital

Malmo, , Sweden

Cityheart

Stockholm, , Sweden

Södersjukhuset Stockholm

Stockholm, , Sweden

Karolinska University Hospital, Huddinge

Stockholm, , Sweden

Kantonsspital Baden AG

Baden, , Switzerland

Universitätsspital Basel

Basel, , Switzerland

Hôpitaux Universitaires de Genève

Geneva, , Switzerland

University of Lausanne Unisanté

Lausanne, , Switzerland

Cardio Center Luzern

Lucerne, , Switzerland

Kardiolab

Olten, , Switzerland

Solothurner Spitäler AG

Olten, , Switzerland

Kantonsspital St. Gallen

Sankt Gallen, , Switzerland

Cardiologue FMH

Yverdon-les-Bains, , Switzerland

Klinik Hirslanden

Zurich, , Switzerland

Universitätsspital Zürich

Zurich, , Switzerland

Craigavon Area Hospital

Craigavon, Armagh, United Kingdom

The Boathouse Sugery

Reading, Berkshire, United Kingdom

Oak Tree Surgery

Liskeard, Cornwall, United Kingdom

Newquay Health Centre

Newquay, Cornwall, United Kingdom

The Alverton Practice

Penzance, Cornwall, United Kingdom

Knowle House Surgery

Plymouth, Cornwall, United Kingdom

Royal Cornwall Hospital

Truro, Cornwall, United Kingdom

Carmel Medical Practice

Darlington, County Durham, United Kingdom

Fellview Healthcare

Whitehaven, Cumbria, United Kingdom

The Adam Practice

Poole, Dorset, United Kingdom

Manor Park Medical Practice

Leicester, East Midlands, United Kingdom

Southend University Hospital

Southend, Essex, United Kingdom

Barts Health NHS Trust

London, Greater London, United Kingdom

Church End Medical

London, Greater London, United Kingdom

The Friarsgate Practice

Winchester, Hampshire, United Kingdom

Burbage Surgery

Hinckley, Leicestershire, United Kingdom

Liverpool Heart & Chest Hospital NHS Trust

Liverpool, Merseyside, United Kingdom

Breckland Alliance

London, Norfolk, United Kingdom

Carlisle Healthcare

Carlisle, North Cumbria, United Kingdom

Pickering Medical Practice

Pickering, North Yorkshire, United Kingdom

Whitby Group Practice

Whitby, North Yorkshire, United Kingdom

Lakeside Surgery

Corby, Northamptonshire, United Kingdom

Danes Camp Medical Centre

Northampton, Northamptonshire, United Kingdom

Ormeau Clinical Trials Ltd

Belfast, Northern Ireland, United Kingdom

Branch End Surgery

Stocksfield, Northumberland, United Kingdom

Princess Royal Hospital

Shrewsbury, Shropshire, United Kingdom

Princess Royal Hospital

Telford, Shropshire, United Kingdom

Heart of Bath Medical Partnership

Bath, Somerset, United Kingdom

Clifton Medical Centre

Rotherham, South Yorkshire, United Kingdom

Brockwood Medical Practice

Brockham, Surrey, United Kingdom

Staploe Medical Centre

Soham, Surrey, United Kingdom

North Tyneside General Hospital

North Shields, Tyne and Wear, United Kingdom

Sunderland Royal Hospital

Sunderland, Tyne and Wear, United Kingdom

Glan Clwyd Hospital

Bodelwyddan, Wales, United Kingdom

Sherbourne Medical Centre

Royal Leamington Spa, Warwickshire, United Kingdom

Huddersfield Hospital

Swindon, West Yorkshire, United Kingdom

Great Western Hospital Swindon

Huddersfield, Wiltshire, United Kingdom

Great Western Hospital Swindon

Swindon, Wiltshire, United Kingdom

Huddersfield Hospital

Huddersfield, Yorkshire, United Kingdom

The Atherstone Surgery

Atherstone, , United Kingdom

Layton Medical Centre

Blackpool, , United Kingdom

Waterloo Medical Care

Blackpool, , United Kingdom

Llanedeyrn Health Centre

Cardiff, , United Kingdom

Ely Bridge Surgery

Cardiff, , United Kingdom

Holderness Health Surgery

Hedon, , United Kingdom

Hull Royal Infirmary

Hull, , United Kingdom

Temple Sowerby Medical Practice

Penrith, , United Kingdom

Wansford and Kings Cliffe Practice

Peterborough, , United Kingdom

Panthera Preston

Preston, , United Kingdom

Ecclesfield Group Practice

Sheffield, , United Kingdom

Royal Albert Edward Infirmary

Wigan, , United Kingdom

Countries

Austria; Belgium; Denmark; Finland; France; Germany; Ireland; Italy; Netherlands; Portugal; Spain; Sweden; Switzerland; United Kingdom

References

Arca M, Calabro P, Solini A, Pirillo A, Gambacurta R, Ray KK, Catapano AL; SANTORINI Italian Group. Challenges in achieving LDL-C goals: Insights from the Italian SANTORINI study cohort. Nutr Metab Cardiovasc Dis. 2025 Oct 14:104412. doi: 10.1016/j.numecd.2025.104412. Online ahead of print.

Reference Type: DERIVED

PMID: 41125511 (View on PubMed)

Mostaza JM, Garcia-Ortiz L, Suarez Tembra MA, Talavera Calle P, Chimeno Garcia J, Escolar Perez V, Diaz-Diaz JL, Manzano-Espinosa L, Catapano AL, Ray KK, Diaz Moya G, Pedro-Botet Montoya J; en representacion del grupo de investigadores de SANTORINI Espana. Failure of LDL-C goals achievement and underuse of lipid-lowering therapies in patients at high and very high cardiovascular risk: Spanish subset from the European SANTORINI study. Rev Clin Esp (Barc). 2025 Feb;225(2):78-84. doi: 10.1016/j.rceng.2024.11.004. Epub 2024 Nov 28.

Reference Type: DERIVED

PMID: 39613100 (View on PubMed)

Ray KK, Haq I, Bilitou A, Manu MC, Burden A, Aguiar C, Arca M, Connolly DL, Eriksson M, Ferrieres J, Laufs U, Mostaza JM, Nanchen D, Rietzschel E, Strandberg T, Toplak H, Visseren FLJ, Catapano AL; SANTORINI Study Investigators. Treatment gaps in the implementation of LDL cholesterol control among high- and very high-risk patients in Europe between 2020 and 2021: the multinational observational SANTORINI study. Lancet Reg Health Eur. 2023 Apr 5;29:100624. doi: 10.1016/j.lanepe.2023.100624. eCollection 2023 Jun.

Reference Type: DERIVED

PMID: 37090089 (View on PubMed)

Provided Documents

Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

DSE-HCL-01-19-EU

Identifier Type: -

Identifier Source: org_study_id