Identification of Predictors for Clinical Outcomes in Femoroacetabular Impingement Surgery

NCT ID: NCT04243447

Last Updated: 2025-10-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

747 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-02-02

Study Completion Date

2025-11-29

Brief Summary

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The overarching goal of the study is to improve the surgical treatment outcomes of FAI, which is affecting an increasing number of military personnel and young active individuals in the general population. The proposed study will investigate critical patient, disease, and surgical treatment predictors of FAI surgery outcomes.

Detailed Description

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PROCEDURES:

Potential participants will be identified at their initial PI's outpatient clinic at which the PI will meet with the patient and determine if the patient should be treated surgically due to a diagnosis of FAI. Once the PI identifies the patient as a surgical candidate, the research study team in the clinic will approach the patient with study information to discuss. If the patient would like to participate, the patient will sign an informed consent document (assent document for minors) and begin completing study-specific information. If the patient would like to take the study documents home to consider participation, the research team member will provide his/her contact information to the patient.

SPECIFIC AIMS:

1. Determine the predictors of mid-term patient-reported outcomes (PROs) and treatment failures in an established prospective longitudinal cohort of Femoroacetabular Impingement (FAI) surgeries.
2. Determine the impact of three-dimensional femoral and acetabular morphology on PROs at short-term follow-up in a novel prospective longitudinal cohort of arthroscopic FAI surgery.
3. Determine if the new Patient-Reported Outcome Measurement Information System (PROMIS) correlates with legacy PROs in patients undergoing FAI surgery.

DATA COLLECTION:

1. Retrospective Follow-up (FAI-1): The original cohort includes previously consented participants in a closed-to-enrollment study who underwent FAI surgical treatment in the past. This cohort will be followed to investigate the most important predictors of FAI surgery outcomes. In Specific Aim 1, we propose to analyze mid-term follow-up (minimum 8 years) of the FAI-1 cohort to identify important predictors of treatment outcomes and failures in FAI surgery.
2. Prospective Enrollment (FAI-2): Consented participants, in the actively enrolling study, will be enrolled in a new multicenter longitudinal prospective arthroscopic FAI surgery cohort and followed to a minimum 2 years post-surgery (T2). The primary outcome measures will be the collection of the patient report outcomes (PROs) that will be analyzed in order to improve surgical care and outcomes. These clinical outcome metrics will be assessed at baseline, 3 months, 6 month, 1 year, and 2 year postoperatively.

Conditions

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Femoracetabular Impingement

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

1. Age 14 - 40 years
2. Skeletally Mature
3. Failure of 6 weeks of conservative treatment
4. Primary surgery (Hip Arthroscopic Treatment)

a. Surgical treatment of FAI with hip arthroscopy
5. Tonnis 0 -1 OA, with greater than 2 mm of joint space
6. Clinical diagnosis of FAI (cam or combined; alpha \>50 degrees)

Exclusion Criteria

1. Not a surgical candidate
2. Skeletally Immature
3. Acetabular Dysplasia (LCEA \< 20)
4. Tonnis 2+ OA
5. Previous ipsilateral hip surgery
6. Previous major hip trauma (hip fractures, hip dislocations)
7. Additional disease processes (e.g., Avascular Necrosis (AVN), synovial disease, Ehlers-Danlos Syndrome (EDS), neuromuscular disorders)
8. Unable to consent due to mental faculty
9. Pregnant women
10. Non-English speaking patients
11. Prisoners or other vulnerable populations
Minimum Eligible Age

14 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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San Antonio Military Medical Center

FED

Sponsor Role collaborator

William Beaumont Hospitals

OTHER

Sponsor Role collaborator

Boston Children's Hospital

OTHER

Sponsor Role collaborator

CHU de Quebec-Universite Laval

OTHER

Sponsor Role collaborator

Mayo Clinic

OTHER

Sponsor Role collaborator

Twin Cities Orthopedics

OTHER

Sponsor Role collaborator

Regents of the University of Michigan

UNKNOWN

Sponsor Role collaborator

Ottawa Hospital Research Institute

OTHER

Sponsor Role collaborator

University of Texas Southwestern Medical Center

OTHER

Sponsor Role collaborator

University of Iowa

OTHER

Sponsor Role collaborator

University of Colorado, Denver

OTHER

Sponsor Role collaborator

Children's Hospital of Eastern Ontario

OTHER

Sponsor Role collaborator

University of Wisconsin, Madison

OTHER

Sponsor Role collaborator

Washington University School of Medicine

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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John C Clohisy, MD

Role: PRINCIPAL_INVESTIGATOR

Washington University School of Medicine

Locations

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University of Colorado

Aurora, Colorado, United States

Site Status

University of Iowa

Iowa City, Iowa, United States

Site Status

Boston Children's Hospital

Boston, Massachusetts, United States

Site Status

University of Michigan

Ann Arbor, Michigan, United States

Site Status

Twin Cities Orthopedics

Edina, Minnesota, United States

Site Status

Mayo Clinic

Rochester, Minnesota, United States

Site Status

Washington University School of Medicine

St Louis, Missouri, United States

Site Status

Scottish Rite Hospital for Children

Dallas, Texas, United States

Site Status

San Antonio Military Medical Center

San Antonio, Texas, United States

Site Status

University of Wisconsin, Madison

Madison, Wisconsin, United States

Site Status

Children's Hospital of Eastern Ontario

Ottawa, Ontario, Canada

Site Status

The Ottawa Hospital

Ottawa, Ontario, Canada

Site Status

CHU de Quebec - Universite Laval

Québec, Quebec, Canada

Site Status

Countries

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United States Canada

Provided Documents

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Document Type: Informed Consent Form

View Document

Other Identifiers

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201909174

Identifier Type: -

Identifier Source: org_study_id

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