Immunologic Biomarker Profile of Cerebrospinal Fluid

NCT ID: NCT04202055

Last Updated: 2019-12-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

165 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-01-02

Study Completion Date

2019-08-31

Brief Summary

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The aim of this study was the describe the Immunologic biomarker profile of cerebrospinal fluid in multiple sclerosis patients

Detailed Description

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Conditions

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Multiple Sclerosis Neuromyelitis Optica

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Neuromyelitis optica with anti-MOG

Biomarker analysis

Intervention Type OTHER

Detection of biomarker in cerebrospinal fluid

Patients with Neuromyelitis optica with anti-AQP4

Biomarker analysis

Intervention Type OTHER

Detection of biomarker in cerebrospinal fluid

Seronegative patients with Neuromyelitis optica

Biomarker analysis

Intervention Type OTHER

Detection of biomarker in cerebrospinal fluid

Patients with recurrent-remitting multiple sclerosis

Patients with recurrent-remitting multiple sclerosis with medullary or optic involvement

Biomarker analysis

Intervention Type OTHER

Detection of biomarker in cerebrospinal fluid

Progressive multiple sclerosis patients

Biomarker analysis

Intervention Type OTHER

Detection of biomarker in cerebrospinal fluid

Symptomatic controls

Biomarker analysis

Intervention Type OTHER

Detection of biomarker in cerebrospinal fluid

Interventions

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Biomarker analysis

Detection of biomarker in cerebrospinal fluid

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* patients who have had neuromyelitis ptica with anti-AQP4 antibodies, or anti- Myelin Oligodendrocyte Glycoprotein antibodies, or double seronegative antibodies.
* Neuromyelitis Optica patients have been prospectively included in the OFSEP collection
* Multiple sclerosis patients, isolated myelitis or optic neuritis patients, and symptomatic controls whose samples will come from the "NEURO" collection of the Hospital Biological Collections Center,
* Patients have given their free consent for use of their samples in research
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Centre Hospitalier Universitaire de Nīmes

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Eric Thouvenot

Role: PRINCIPAL_INVESTIGATOR

CHU Nimes

Locations

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CHU de Nimes

Nîmes, , France

Site Status

Countries

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France

Other Identifiers

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NIMAO/2017-01/ET-01

Identifier Type: -

Identifier Source: org_study_id