RheOx Registry Study in Europe

NCT ID: NCT04182841

Last Updated: 2022-03-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-01-09

Study Completion Date

2025-12-15

Brief Summary

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Post-market clinical study (registry study) to collect post-market safety and clinical utility data in European patients with chronic bronchitis treated with RheOx.

Detailed Description

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RheOx is a device-based, energy delivery system that delivers high frequency short duration energy to the airway epithelium and sub-mucosal tissue layers. The energy is delivered via a proprietary catheter through the bronchoscope.

Two sessions of treatment will be delivered one month apart. The right lung is treated at the first treatment session and the left lung is treated at the second treatment session (approximately one month after the right side is treated). Treatment will be delivered by a respiratory physician (interventional pulmonologist) in a tertiary teaching hospital during a bronchoscopic procedure. The bronchoscopy will be delivered during general anaesthesia. It is anticipated that the bronchoscopic procedure will last less than 60 minutes in total. Treatment will be deemed to have been delivered following the successful treatment during the two bronchoscopies.

Subjects will be required to submit to several tests and questionnaires during the study including respiratory function tests.

Conditions

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Chronic Bronchitis COPD

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

RheOx Treatment
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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RheOx Treatment

RheOx is a CE-marked device-based, energy delivery system that delivers energy to ablate soft tissue such as the airway epithelium and sub-mucosal tissue layers. The energy is delivered via a proprietary catheter through the bronchoscope.

Group Type OTHER

RheOx

Intervention Type DEVICE

RheOX is a CE-marked device-based, energy delivery system that delivers energy to ablate soft tissue such as the airway epithelium and sub-mucosal tissue layers. The energy is delivered via a proprietary catheter through the bronchoscope.

Interventions

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RheOx

RheOX is a CE-marked device-based, energy delivery system that delivers energy to ablate soft tissue such as the airway epithelium and sub-mucosal tissue layers. The energy is delivered via a proprietary catheter through the bronchoscope.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Patient has moderate to severe Chronic Bronchitis

Exclusion Criteria

* Patient has an implantable cardioverter defibrillator, pacemaker, or any other implantable electronic device.
* Patient has history of ventricular tachyarrhythmia or any clinically significant atrial tachyarrhythmia (i.e., abnormality with vital signs) and/or history of type II second or third degree AV block.
* Patient has airway stent(s), valves, coils, or other lung implant/prosthesis.
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Gala Therapeutics, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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William Krimsky, MD

Role: STUDY_DIRECTOR

Gala Therapeutics, Inc.

Locations

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Otto Wagner Spital

Vienna, , Austria

Site Status RECRUITING

Pneumologie Thoraxklinik Heidelberg gGmbH University of Heidelberg

Heidelberg, Baden-Wurttemberg, Germany

Site Status RECRUITING

Countries

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Austria Germany

Central Contacts

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Jeff Keeney

Role: CONTACT

650-268-4252

Facility Contacts

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Kelly Gross

Role: primary

0043 664 4385355

Brigitte Rump

Role: primary

49 (6221) 396-1211

Other Identifiers

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CS005

Identifier Type: -

Identifier Source: org_study_id

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