Assessment of Ovarian Reserve After Laparoscopic Cystectomy Versus Aspiration/Electrocoagulation in the Treatment of Ovarian Endometrioma
NCT ID: NCT04151173
Last Updated: 2021-06-11
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
60 participants
INTERVENTIONAL
2019-11-01
2022-11-30
Brief Summary
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The aim of the study is to determine whether and to what extent the two surgical procedures for ovarian endometrioma, cystectomy and aspiration/electrocoagulation, affect ovarian reserve. The investigators intend to confirm the clinical utility of ultrasonic classification of ovarian endometrioma, FSH, AMH and AFC in the assessment of ovarian reserve, and to promote their use in predicting decreased ovarian reserve.
The surgical excision of cystic wall, cystic fluid and peritoneal fluid will be subjected to transmission electron microscope, high resolution mass spectrometry and single-cell RNA sequencing to investigate their cellular and molecular features.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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aspiration/electrocoagulation
laparoscopic aspiration/electrocoagulation
laparoscopic aspiration/electrocoagulation of ovarian endometrioma
cystectomy
laparoscopic cystectomy
laparoscopic cystectomy of ovarian endometrioma
Interventions
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laparoscopic aspiration/electrocoagulation
laparoscopic aspiration/electrocoagulation of ovarian endometrioma
laparoscopic cystectomy
laparoscopic cystectomy of ovarian endometrioma
Eligibility Criteria
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Inclusion Criteria
* Regular menstrual cycles
* Female diagnosed by ultrasound with unilateral ovarian endometrioma ≥4cm and ≤6cm.
Exclusion Criteria
* Suspected or proven ovarian malignancy.
* Previous ovarian surgery.
* Evidence of polycystic ovary syndrome.
* Evidence of premature ovarian failure or premature menopause.
* Endocrinological diseases affecting ovarian reserve e.g. Diabetes mellitus, hypothyroidism.
* Pregnancy test is positive.
* Lactation.
* Unable or unwilling to give written consent.
18 Years
40 Years
FEMALE
No
Sponsors
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International Peace Maternity and Child Health Hospital
OTHER
Shanghai Tongji Hospital, Tongji University School of Medicine
OTHER
Shanghai First Maternity and Infant Hospital
OTHER
Responsible Party
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Locations
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Shanghai First Maternity and Infant Hospital
Shanghai, Shanghai Municipality, China
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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ShanghaiFMIH Jing Sun
Identifier Type: -
Identifier Source: org_study_id
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