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Noradrenaline Infusion Versus Phenylephrine Infusion in Improving Serum Lactate Level in HIPEC

NCT ID: NCT04144465

Last Updated: 2024-05-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-11-01

Study Completion Date

2023-12-30

Brief Summary

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ABG PARAMETERS ARE CHANGED DURING HIPEC, WE TRIED TO FIND COMPARISON BETWEEN NORADRENALINE AND PHENYLEPHRINE IN OPTIMIZING ABG PARAMETERS THAT REFLECTS ORGAN PERFUSIONS ESPECIALLY SERUM LACTATE

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Detailed Description

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Arterial blood gas testing is considered one of the most important and widely used test in the detection of acidosis, alkalosis, electrolytes disturbance and tissue perfusion. in regard to tissue perfusion serum lactate above 4 mmol/L indicates poor tissue perfusion. serum lactate could be measured at ABG or separately. in this study we will test the effect of both noradrenaline and phenylephrine on lactate level at ABG during the stage of HIPAC in managing abdominal cancer patients.

Conditions

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Hyperthermic Intraperitoneal Chemotherapy (HIPEC)

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Caregivers

Study Groups

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NORADRENALIN

NORADRENALINE INFUSION

Group Type ACTIVE_COMPARATOR

NORADRENALIN

Intervention Type DRUG

DRUG THAT IS IMPROVING TISSUE AND ORGAN PERFUSION

PHENYLEPHRINE

PHENYLEPHRINE INFUSION

Group Type ACTIVE_COMPARATOR

PHENYLEPHRINE

Intervention Type DRUG

DRUG THAT IS IMPROVING TISSUE AND ORGAN PERFUSION

Interventions

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NORADRENALIN

DRUG THAT IS IMPROVING TISSUE AND ORGAN PERFUSION

Intervention Type DRUG

PHENYLEPHRINE

DRUG THAT IS IMPROVING TISSUE AND ORGAN PERFUSION

Intervention Type DRUG

Other Intervention Names

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PERFUSION

Eligibility Criteria

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Inclusion Criteria

* CANCER PATIENTS ENROLLED FOR HIPEC

Exclusion Criteria

* DRUG SENSITIVITY
Minimum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Suez Canal University

OTHER

Sponsor Role lead

Responsible Party

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Abdelrhman Alshawadfy

Clinical professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Suez Canal University

Ismailia, , Egypt

Site Status

Countries

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Egypt

Other Identifiers

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noradrenaline vs phenylephrine

Identifier Type: -

Identifier Source: org_study_id

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