Post-Market Optimization Study of the EMPOWER® RF Catheter to Ablate Soft Tissue Lesions in the Lung

NCT ID: NCT04131777

Last Updated: 2020-03-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

15 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-12-09

Study Completion Date

2020-11-30

Brief Summary

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A post-market study to assess the performance and safety of a RF ablation catheter to bronchoscopically ablate lung lesions will be evaluated in patients with confirmed diagnosis of non-small cell lung cancer or metastatic lung lesions who are scheduled for surgical resection.

Detailed Description

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This study is a prospective, single-arm, multi-center, post-market study of bronchoscopic radio frequency (RF) ablation treatment malignant lung lesions prior to surgical resection. Up to 15 patients will be treated at the participating sites.

Patients identified for the study will have been scheduled for surgical resection as part of their treatment for lung lesions. The RF ablation procedure will be performed during a standard-of-care bronchoscopic procedure at minimum of 24 hours prior to resection. The patients exits the study following surgical resection. The resected tissue will undergo pathological evaluation for tissue viability.

Conditions

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Lung Diseases

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Roll-in

Initial patients enrolled until optimal RF algorithm is determined

Radiofrequency (RF) catheter

Intervention Type DEVICE

A catheter introduced into the lung lesion via a bronchoscope, used to deliver radiofrequency (RF) energy for the purpose of ablation

Optimized

Patients treated using optimal RF algorithm

Radiofrequency (RF) catheter

Intervention Type DEVICE

A catheter introduced into the lung lesion via a bronchoscope, used to deliver radiofrequency (RF) energy for the purpose of ablation

Interventions

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Radiofrequency (RF) catheter

A catheter introduced into the lung lesion via a bronchoscope, used to deliver radiofrequency (RF) energy for the purpose of ablation

Intervention Type DEVICE

Other Intervention Names

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EMPOWER® RF Catheter

Eligibility Criteria

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Inclusion Criteria

1. Age ≥ 18 years at screening
2. Proven NSCLC or pulmonary metastases from extra-thoracic primary tumor
3. Eligible for standard of practice lung resection (pneumonectomy, lobectomy)
4. Tumor/lesion \> 2cm along the major diameter with no visible necrosis
5. Signed informed consent form

Exclusion Criteria

1. An implantable pacemaker, defibrillator, or other active implants
2. Any other severe or life-threatening comorbidity that could increase the risk associated with bronchoscopic RF ablation
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Uptake Medical Technology, Inc.

INDUSTRY

Sponsor Role collaborator

Broncus Medical Inc

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Felix J Herth, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Heidelberg University

Locations

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Thoraxklinik Heidelberg

Heidelberg, , Germany

Site Status RECRUITING

Countries

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Germany

Central Contacts

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Julie Arneson, BSc

Role: CONTACT

206 926-7408

Facility Contacts

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Michaela Korthoeber, Coordinator

Role: primary

+49 6221 396 8253

Other Identifiers

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Protocol 46

Identifier Type: -

Identifier Source: org_study_id

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