Radiofrequency Ablation in Treating Patients With Refractory or Advanced Lung Cancer

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2000-05-31

Brief Summary

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RATIONALE: Radiofrequency ablation uses high-frequency electric current to kill tumor cells. CT-guided radiofrequency ablation may be effective treatment for lung cancer.

PURPOSE: Phase II trial to study the effectiveness of radiofrequency ablation in treating patients who have refractory or advanced lung cancer.

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Detailed Description

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OBJECTIVES:

* Determine the safety and toxicity of radiofrequency ablation in patients with refractory or advanced pulmonary malignancies.
* Determine the efficacy of this treatment, in terms of local control, in these patients.
* Determine whether CT scan is a reasonable imaging assessment tool for treatment delivery and follow-up in these patients.

OUTLINE: Patients undergo percutaneous CT-guided radiofrequency ablation directly to the tumor over 2 hours.

Patients are followed at 1, 3, 6, and 12 months.

PROJECTED ACCRUAL: A total of 30 patients will be accrued for this study.

Conditions

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Lung Cancer Malignant Mesothelioma Metastatic Cancer Thymoma and Thymic Carcinoma

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Interventions

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radiofrequency ablation

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of a primary or secondary intrathoracic malignancy

* Any cell type or origin
* Involving the intrapulmonary, mediastinal, or pleural/chest wall
* Inoperable primary or metastatic cancer to the lung
* Refractory to or not amenable to conventional therapy (e.g., surgery, chemotherapy, or radiotherapy)
* Single or multiple lesions that are non-contiguous with vital structures or organs such as:
* Trachea
* Heart
* Aorta
* Great vessels
* Esophagus
* Less than 5 cm in largest dimension
* Accessible via percutaneous transthoracic route
* Hepatic:

* Coagulation profile normal

Eligible Sex

ALL

Accepts Healthy Volunteers

No