A Study to Determine if Identification of Undiagnosed Atrial Fibrillation in People at Least 70 Years of Age Reduces the Risk of Stroke

NCT ID: NCT04126486

Last Updated: 2023-07-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

11931 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-12-17

Study Completion Date

2023-06-30

Brief Summary

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The purpose of this study is to determine if an AF detection intervention in men and women at least 70 years of age with undiagnosed atrial fibrillation (AF) or atrial flutter (AFL) reduces the person-years incidence rate of stroke compared to usual care (no AF detection intervention).

Detailed Description

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This a prospective, randomized study in primary care practices.

Conditions

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Atrial Fibrillation Atrial Flutter

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Zio®XT Monitor Arm

Group Type OTHER

Zio®XT Monitor

Intervention Type OTHER

A Zio® XT monitor will be affixed to the participant's chest

Usual Care Arm

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Zio®XT Monitor

A Zio® XT monitor will be affixed to the participant's chest

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Men and women at least 70 years of age who are new or established participants in the primary care practice
* Willing to provide consent to participate in the study and to use personal health information to ascertain endpoints from the Center for Medicare \& Medicaid Services (CMS) Medicare Claims Database and to access data from health records
* Health insurance by Medicare Parts A \& B (Medicare Fee-for-service)

Exclusion Criteria

* Oral anticoagulation (OAC) for any indication at the time of enrollment
* History of Atrial Fibrillation (AF) or Atrial Flutter (AFL) as documented in the participant's current medical problem list
* Any condition the investigator considers a contraindication to OAC, e.g., bleeding that required medical attention or severe renal impairment
* Any condition the investigator considers will prevent compliance with study instructions
* Implanted cardiac devices (pacemakers, implantable cardiac defibrillators, or cardiac resynchronization therapy, and implantable loop recorders)
* History of allergy to adhesive
* Not able to wear the Zio®XT monitor or not able to apply the monitor by herself/himself or with the help of a caregiver
Minimum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Pfizer

INDUSTRY

Sponsor Role collaborator

Bristol-Myers Squibb

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Bristol-Myers Squibb

Role: STUDY_DIRECTOR

Bristol-Myers Squibb

Locations

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Local Institution - 0302

Birmingham, Alabama, United States

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Local Institution - 0360

Guntersville, Alabama, United States

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Local Institution - 0158

Montgomery, Alabama, United States

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Kingman, Arizona, United States

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Peoria, Arizona, United States

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Local Institution - 0237

Peoria, Arizona, United States

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Phoenix, Arizona, United States

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Local Institution - 0271

Phoenix, Arizona, United States

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Yuma, Arizona, United States

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Local Institution - 0097

Little Rock, Arkansas, United States

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Hope Clinical Research

Canoga Park, California, United States

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Fremont, California, United States

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Fullerton, California, United States

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Oakland, California, United States

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Sacramento, California, United States

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Toluca Lake, California, United States

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Aventura, Florida, United States

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Local Institution - 0143

Boynton Beach, Florida, United States

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Local Institution - 0232

Clearwater, Florida, United States

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Local Institution - 0017

Clearwater, Florida, United States

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Local Institution - 0062

DeLand, Florida, United States

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University Clinical Research-Deland LLC dba Accel Research Sites

DeLand, Florida, United States

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Local Institution - 0350

Doral, Florida, United States

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Local Institution - 0367

Fort Lauderdale, Florida, United States

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Local Institution - 0161

Fort Lauderdale, Florida, United States

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Vanguard Clinical Research, LLC

Fort Myers, Florida, United States

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Finlay Medical Research Corp

Greenacres City, Florida, United States

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Local Institution - 0348

Hialeah, Florida, United States

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Local Institution - 0358

Hialeah, Florida, United States

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Local Institution - 0219

Hialeah, Florida, United States

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Jacksonville, Florida, United States

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Local Institution - 0368

Jacksonville, Florida, United States

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Local Institution - 0277

Jacksonville, Florida, United States

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Local Institution - 0375

Lake City, Florida, United States

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Nova Clinical Research Center Inc

Miami, Florida, United States

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Local Institution - 0025

Miami, Florida, United States

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Local Institution - 0296

Miami, Florida, United States

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Miami, Florida, United States

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Miami, Florida, United States

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Local Institution - 0300

Miami, Florida, United States

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Local Institution - 0371

Miami, Florida, United States

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Miami, Florida, United States

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Local Institution - 0149

Miami Beach, Florida, United States

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Miami Lakes, Florida, United States

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Miami Shores, Florida, United States

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Mt. Dora, Florida, United States

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Oviedo, Florida, United States

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Palm Harbor, Florida, United States

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Palm Springs, Florida, United States

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Tampa, Florida, United States

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Tampa, Florida, United States

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Weston, Florida, United States

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Albany, Georgia, United States

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Atlanta, Georgia, United States

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Columbus, Georgia, United States

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Local Institution - 0033

Eatonton, Georgia, United States

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Fayetteville, Georgia, United States

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Rincon, Georgia, United States

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Savannah, Georgia, United States

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Woodstock, Georgia, United States

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Chicago, Illinois, United States

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Evergreen Park, Illinois, United States

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Gillespie, Illinois, United States

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Wauconda, Illinois, United States

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Indianapolis, Indiana, United States

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Michigan City, Indiana, United States

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Local Institution - 0338

Ames, Iowa, United States

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University of Iowa

Iowa City, Iowa, United States

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Wichita, Kansas, United States

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Lexington, Kentucky, United States

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Eunice, Louisiana, United States

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New Orleans, Louisiana, United States

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Zachary, Louisiana, United States

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Annapolis, Maryland, United States

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Johns Hopkins

Baltimore, Maryland, United States

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Elkridge, Maryland, United States

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Rockville, Maryland, United States

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Boston, Massachusetts, United States

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Boston, Massachusetts, United States

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Haverhill, Massachusetts, United States

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New Bedford, Massachusetts, United States

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Worcester, Massachusetts, United States

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Caro, Michigan, United States

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Detroit, Michigan, United States

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Sterling Heights, Michigan, United States

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Troy, Michigan, United States

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Rochester, Minnesota, United States

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Belzoni Family Practice

Belzoni, Mississippi, United States

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Jackson, Mississippi, United States

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Petal, Mississippi, United States

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Picayune, Mississippi, United States

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Quinn Healthcare/SKYCRNG

Ridgeland, Mississippi, United States

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St Louis, Missouri, United States

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Norfolk, Nebraska, United States

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Henderson, Nevada, United States

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Las Vegas, Nevada, United States

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Linden, New Jersey, United States

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Brooklyn, New York, United States

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Cooperstown, New York, United States

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East Syracuse, New York, United States

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Endwell, New York, United States

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Niagara Falls, New York, United States

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Digiovanna Institute For Medical Education

North Massapequa, New York, United States

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Black Mountain, North Carolina, United States

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Burlington, North Carolina, United States

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Cary, North Carolina, United States

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PMG Research of Charlotte, LLC

Charlotte, North Carolina, United States

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Charlotte, North Carolina, United States

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Durham, North Carolina, United States

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Fayetteville, North Carolina, United States

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Franklinton, North Carolina, United States

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Greensboro, North Carolina, United States

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Hickory, North Carolina, United States

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Matthews, North Carolina, United States

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Raleigh, North Carolina, United States

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Rocky Mount, North Carolina, United States

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Salisbury, North Carolina, United States

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Statesville, North Carolina, United States

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Statesville, North Carolina, United States

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Wilmington, North Carolina, United States

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Winston-Salem, North Carolina, United States

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Sterling Research Group

Cincinnati, Ohio, United States

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Cincinnati, Ohio, United States

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Cleveland, Ohio, United States

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Columbus, Ohio, United States

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Dayton Clinical Research

Dayton, Ohio, United States

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Dayton, Ohio, United States

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Philadelphia, Pennsylvania, United States

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Pittsburgh, Pennsylvania, United States

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Pittsburgh, Pennsylvania, United States

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Pittsburgh, Pennsylvania, United States

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Uniontown, Pennsylvania, United States

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Uniontown, Pennsylvania, United States

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East Providence, Rhode Island, United States

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Bristol, Tennessee, United States

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Knoxville, Tennessee, United States

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Morristown, Tennessee, United States

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Nashville, Tennessee, United States

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Wellness Clinical Research

Allen, Texas, United States

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Austin, Texas, United States

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Austin, Texas, United States

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HRMD Research

Dallas, Texas, United States

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Denton, Texas, United States

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Invesclinic.U.S,LLC

Edinburg, Texas, United States

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Friendswood, Texas, United States

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Georgetown, Texas, United States

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Houston, Texas, United States

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Houston, Texas, United States

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Hurst, Texas, United States

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Laredo, Texas, United States

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Mesquite, Texas, United States

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Pearland, Texas, United States

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Pflugerville, Texas, United States

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Pharr, Texas, United States

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Plano, Texas, United States

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Plano, Texas, United States

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SA Premiere Internal Medicine

San Antonio, Texas, United States

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San Antonio, Texas, United States

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San Marcos, Texas, United States

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Sugar Land, Texas, United States

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Sugar Land, Texas, United States

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The Woodlands, Texas, United States

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The Woodlands, Texas, United States

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Tyler, Texas, United States

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Bountiful, Utah, United States

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Appomattox, Virginia, United States

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Burke, Virginia, United States

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Forest, Virginia, United States

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Suffolk, Virginia, United States

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Winchester, Virginia, United States

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Local Institution - 0364

Winchester, Virginia, United States

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Everett, Washington, United States

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Tacoma, Washington, United States

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Eau Claire, Wisconsin, United States

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Local Institution - 0335

La Crosse, Wisconsin, United States

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Local Institution - 0288

Madison, Wisconsin, United States

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Countries

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United States

References

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Singer DE, Atlas SJ, Go AS, Lubitz SA, McManus DD, Dolor RJ, Chatterjee R, Rothberg MB, Rushlow DR, Crosson LA, Aronson RS, Mills D, Patlakh M, Gallup D, O'Brien EC, Lopes RD. Atrial Fibrillation Burden on a 14-Day ECG Monitor: Findings From the GUARD-AF Trial Screening Arm. JACC Clin Electrophysiol. 2025 Jan;11(1):110-119. doi: 10.1016/j.jacep.2024.08.010. Epub 2024 Sep 1.

Reference Type DERIVED
PMID: 39297839 (View on PubMed)

Lopes RD, Atlas SJ, Go AS, Lubitz SA, McManus DD, Dolor RJ, Chatterjee R, Rothberg MB, Rushlow DR, Crosson LA, Aronson RS, Patlakh M, Gallup D, Mills DJ, O'Brien EC, Singer DE. Effect of Screening for Undiagnosed Atrial Fibrillation on Stroke Prevention. J Am Coll Cardiol. 2024 Nov 19;84(21):2073-2084. doi: 10.1016/j.jacc.2024.08.019. Epub 2024 Sep 1.

Reference Type DERIVED
PMID: 39230544 (View on PubMed)

Related Links

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Other Identifiers

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CV185-749

Identifier Type: -

Identifier Source: org_study_id

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