Femtosecond Laser-assisted Arcuate Incisions Versus Manual Arcuate Incisions Outcomes

NCT ID: NCT04126174

Last Updated: 2021-09-05

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

41 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-10-15

Study Completion Date

2021-03-20

Brief Summary

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This study is designed to compare the effectiveness of LenSx laser arcuate relaxing incisions vs. manual (blade) arcuate relaxing incisions in patients with low, but significant, levels of astigmatism.

Detailed Description

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This study is a comparative, prospective, randomized contralateral eye study of visual outcomes after LenSx laser arcuate relaxing incisions utilizing the Woodcock nomogram at 90% thickness vs. manual (blade) fixed keratome diamond knife at 600 microns for arcuate relaxing incisions utilizing the Donnenfeld nomogram. Subjects will be assessed pre-operatively and at 1 day, 1 month and 3 months post-operatively. Clinical evaluations will include measurement of visual acuity, manifest refraction and corneal astigmatism measurement with the Lenstar and slit lamp exam.

Conditions

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Cataract

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Contralateral eye study
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Femtosecond limbal relaxing incision (LRI)

Eyes will be treated with arcuate incisions from a femtosecond laser system.

Group Type ACTIVE_COMPARATOR

femtosecond laser system arcuate corneal incision

Intervention Type DEVICE

Corneal arcuate incision made either with a blade (manual) or femtosecond laser system.

Manual LRI

Eyes will be treated with arcuate incisions completed manually with a blade.

Group Type ACTIVE_COMPARATOR

Manual LRI

Intervention Type OTHER

Manual LRI

Interventions

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femtosecond laser system arcuate corneal incision

Corneal arcuate incision made either with a blade (manual) or femtosecond laser system.

Intervention Type DEVICE

Manual LRI

Manual LRI

Intervention Type OTHER

Other Intervention Names

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LRI

Eligibility Criteria

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Inclusion Criteria

Subjects are eligible for the study if they meet the following criteria:

Note: Ocular criteria must be met in both eyes.

* are willing and able to understand and sign an informed consent;
* are willing and able to attend all study visits;
* are more than 40 years of age, of either gender and any race;
* are presenting for cataract surgery or refractive lens exchange with a desire to reduce astigmatism and will be implanted with a non-toric lens
* have good ocular health, with no pathology that compromises visual acuity (outside of residual refractive error and cataract)
* have 0.50 D to 1.75 D of regular corneal astigmatism
* have potential acuity of 20/25 or better
* Are scheduled to have a non-toric monofocal intraocular lens (IOL) (SN60WF) lens implanted in both eyes

Exclusion Criteria

* Irregular astigmatism (e.g. keratoconus)
* Corneal pathology (e.g. scar, dystrophy, pterygium, moderate-to-severe dry eye)
* Monocular status (e.g. amblyopia)
* Previous radial keratotomy, corneal refractive surgery or other corneal surgery (e.g. corneal transplant, lamellar keratoplasty)
* Previous anterior or posterior chamber surgery (e.g., vitrectomy, laser iridotomy)
* Diabetic retinopathy
* Macular pathology (e.g. age-related macular degeneration, epiretinal membrane)
* History of retinal detachment
* Subjects who have an acute or chronic disease or illness that would confound the results of this investigation (e.g., immunocompromised, connective tissue disease, clinically significant atopic disease, diabetes, and any other such disease or illness), that are known to affect post-operative visual acuity.

Pregnancy has a known effect on the stability of refractions and visual acuity. As such, subjects who become pregnant during the study will not be discontinued but their data may be excluded from analyses of effectiveness.
Minimum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Science in Vision

OTHER

Sponsor Role collaborator

Gainesville Eye Associates

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Clayton G Blehm, MD

Role: PRINCIPAL_INVESTIGATOR

Gainesville Eye Associates

Locations

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Gainesville Eye Associates

Gainesville, Georgia, United States

Site Status

Countries

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United States

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

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CB-19-001

Identifier Type: -

Identifier Source: org_study_id

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