Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
314000 participants
OBSERVATIONAL
2019-01-14
2019-03-18
Brief Summary
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Incident cases of lung cancer from 1st January 2006 to 31st December 2012, recorded by Viterbo Cancer Registry, occurring during the period, were considered as primary outcome. People residing in municipalities with Arsenic drinking water concentrations over legal threshold (10 µg/L) were considered as exposed.
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Detailed Description
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Because of its high toxicity and its ubiquitous distribution, that earned the metalloid the first in the Priority list by ATSDR, thus being a main issue in Public Health.
Materials and Methods From 1st January 2006 to 31st December 2012 all the inhabitants, residing in one of the 60 municipalities of Viterbo Province (around 320,279 people) were enrolled. Incident cases of lung cancer, recorded by Viterbo Cancer Registry, occurring during the period, were considered as primary outcome. People residing in municipalities with Arsenic drinking water concentrations over legal threshold (10 µg/L), as provided by Arpa Lazio, were considered as exposed.
Risk difference in developing lung cancer among exposed and not exposed was estimated by Relative Risk (RR) and Attributable Risk (AR).
Conditions
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Study Design
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COHORT
OTHER
Study Groups
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Exposed to high Arsenic concentration
All the inhabitants, residing in one of the municipalities of Viterbo Province with high Arsenic concentration in drinking water, were enrolled
Exposure to Arsenic by drinking water
People residing in municipalities with Arsenic drinking water concentrations over legal threshold (10 µg/L), were considered as exposed.
Exposed to low Arsenic concentration
All the inhabitants, residing in one of the municipalities of Viterbo Province with low Arsenic concentration in drinking water, were enrolled
Exposure to Arsenic by drinking water
People residing in municipalities with Arsenic drinking water concentrations over legal threshold (10 µg/L), were considered as exposed.
Interventions
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Exposure to Arsenic by drinking water
People residing in municipalities with Arsenic drinking water concentrations over legal threshold (10 µg/L), were considered as exposed.
Eligibility Criteria
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Inclusion Criteria
ALL
No
Sponsors
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University of Rome Tor Vergata
OTHER
Responsible Party
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Leonardo Palombi
Leonardo Palombi, Full Professor of Hygiene and Preventive Medicine
Principal Investigators
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Leonardo Palombi, MD
Role: PRINCIPAL_INVESTIGATOR
University Rome Tor Vergata, Roma (Italy)
Locations
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Cancer Registry Viterbo Province
Viterbo, , Italy
Countries
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Other Identifiers
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ArsenicVT2019
Identifier Type: -
Identifier Source: org_study_id
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