Inflammatory Cytokines in Congenital Cataract After Lensectomy and Anterior Vitrectomy

NCT ID: NCT04120818

Last Updated: 2019-10-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

59 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-03-04

Study Completion Date

2017-02-12

Brief Summary

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In this prospective study , a cohort of 58 eyes with congenital cataract from Wenzhou medical university was erolled.33 eyes with congenital cataract was after lensectomy and anterior vitrectomy as post-surger group, 26 eyes without cataract surgery as control group. The cytokines of MCP-1, VEGF, IL-1, IFN-γ, IL-1r,IL-4,IL-17, IL-2,IL-5,G-CSF,IL-12, IL-15 was evaluated

Detailed Description

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Secondary IOL implantation in aphika children and lensectomy and anterior vitrectomy and primary IOL implantation in children with congenital cataract were both performed by the same surgeon(Z.Y.E) and videos were collected to review the capsular reconstruction condition and lens implantation position.

Aqueous humor (100-200 μl) was aspirated from each patient before the surgery. The research was to evaluate the relationship between the cytokine profile in aqueous humor and the state of capsule after Lensectomy and Anterior Vitrectomy.Aqueous humor was obtained , Human Magnetic Luminex Screening Assay was used to determine the aqueous humor levels of cytokines.

Conditions

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Congenital Cataract

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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SIOL group

aphakic children diagnosed with congenital cataract who underwent secondary IOL implantation

secondary IOL implantation

Intervention Type PROCEDURE

reopened the fibrotic, closed capsular bag and achieve IOL placement

PIOL group

children with congenital cataract who underwent lensectomy and anterior vitrectomy and primary IOL implantation

primary IOL implantation

Intervention Type PROCEDURE

lensectomy and anterior vitrectomy and primary IOL implantation

Interventions

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secondary IOL implantation

reopened the fibrotic, closed capsular bag and achieve IOL placement

Intervention Type PROCEDURE

primary IOL implantation

lensectomy and anterior vitrectomy and primary IOL implantation

Intervention Type PROCEDURE

Eligibility Criteria

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Exclusion Criteria

\-
Minimum Eligible Age

10 Months

Maximum Eligible Age

72 Months

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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yin ying zhao

OTHER

Sponsor Role lead

Responsible Party

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yin ying zhao

Clinical professor

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Eye Hosptial of Wenzhou Medical College

Wenzhou, Zhejiang, China

Site Status

Ophthalmology and Optometry Hospital

Wenzhou, Zhejiang, China

Site Status

Countries

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China

Other Identifiers

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yyzhao

Identifier Type: -

Identifier Source: org_study_id

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