Adherence With Continuous-dose Oral Contraceptive: Evaluation of Self-Selection and Use

NCT ID: NCT04112095

Last Updated: 2022-05-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

962 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-09-06

Study Completion Date

2021-08-05

Brief Summary

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This study is designed to assess whether consumers select and use norgestrel 0.075 mg, a progestin only pill for contraception, in a manner consistent with the OTC package directions in an Over-the-Counter (OTC)-like setting.

Detailed Description

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Subjects will be primarily recruited via passive recruiting methods, such as in-store posters, direct mail postcards, and digital space advertising.

Respondents to advertisements will either call the study phone line or visit the study website for prescreening and scheduling of an in-person enrollment visit at a local participating research site.

During the face-to-face enrollment visit, potential subjects who meet the inclusion and exclusion criteria for the study will be given an (empty) study medication package and will be allowed as much time as they need to review the information on the outside of the entire package. Subjects will then be asked if the product is OK or not OK for them to use.

Qualified subjects then will be allowed to obtain (pharmacy sites) or be given (clinic sites) the study product.

Approximately 35 sites will be used, comprising retail pharmacy research sites and women's health clinics or adolescents' clinics.

Conditions

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Contraception

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Drug: Norgestrel 0.075 mg tablets All subjects enrolled in the use phase of this open-label study will be given the opportunity to purchase and take one Norgestrel 0.075 mg tablet daily up to 24 weeks.

Subjects will use the investigational product based on their understanding of the directions on the outer packaging called the Drug Facts Label and information inside the product packaging called the Consumer Information Leaflet.
Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Use Phase Norgestrel 0.075 mg

Norgestrel 0.075 mg tablets to be taken orally, one tablet daily at the same time every day for up to 24 weeks

Group Type EXPERIMENTAL

Norgestrel 0.075 mg tablets

Intervention Type DRUG

All subjects enrolled in the use phase of this open-label study will be given the opportunity to purchase and take one Norgestrel 0.075 mg tablet daily up to 24 weeks.

Subjects will use the investigational product based on their understanding of the directions on the outer packaging called the Drug Facts Label and information inside the product packaging called the Consumer Information Leaflet.

Interventions

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Norgestrel 0.075 mg tablets

All subjects enrolled in the use phase of this open-label study will be given the opportunity to purchase and take one Norgestrel 0.075 mg tablet daily up to 24 weeks.

Subjects will use the investigational product based on their understanding of the directions on the outer packaging called the Drug Facts Label and information inside the product packaging called the Consumer Information Leaflet.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Women who are willing to purchase (in the pharmacies) or be provided (in the clinics, for women younger than 18 years old) oral contraception for their own use for the purposes of the study

Exclusion Criteria

* Cannot read, speak and understand English
* Cannot see well enough to read information on the label
Minimum Eligible Age

11 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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HRA Pharma

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Russ Bradford, MD, MSPH

Role: PRINCIPAL_INVESTIGATOR

Pegus Research, Inc.

Locations

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HRA Pharma Investigational site 1012

Birmingham, Alabama, United States

Site Status

HRA Pharma Investigational Site 1008

Homewood, Alabama, United States

Site Status

HRA Pharma Investigational Site 1038

Mesa, Arizona, United States

Site Status

HRA Pharma Investigational Site 1032

Phoenix, Arizona, United States

Site Status

HRA Pharma Investigational Site 1027

Cerritos, California, United States

Site Status

HRA Pharma Investigational Site 1039

Downey, California, United States

Site Status

HRA Pharma investigational site 1035

Long Beach, California, United States

Site Status

HRA Pharma Investigational Site 1017

Long Beach, California, United States

Site Status

HRA Pharma Investigational Site 1034

Los Angeles, California, United States

Site Status

HRA Pharma Investigational Site 1029

Los Angeles, California, United States

Site Status

HRA Pharma Investigational Site 1028

Los Angeles, California, United States

Site Status

HRA Pharma Investigational Site 1033

Aurora, Colorado, United States

Site Status

HRA Pharma Investigational Site 1023

Dalton, Georgia, United States

Site Status

HRA Pharma Investigational Site 1018

Griffin, Georgia, United States

Site Status

HRA Pharma Investigational Site 1014

Rosedale, Maryland, United States

Site Status

HRA Pharma Investigational Site 1019

Framingham, Massachusetts, United States

Site Status

HRA Pharma Investigational Site 1011

Andover, Minnesota, United States

Site Status

HRA Pharma Investigational Site 1006

Elk River, Minnesota, United States

Site Status

HRA Pharma Investigational Site 1003

Saint Francis, Minnesota, United States

Site Status

HRA Pharma Investigational Site 1020

Saint Louis Park, Minnesota, United States

Site Status

HRA Pharma Investigational Site 1009

Albuquerque, New Mexico, United States

Site Status

HRA Pharma Investigational Site 1007

Albuquerque, New Mexico, United States

Site Status

HRA Pharma Investigational Site 1030

Bronxville, New York, United States

Site Status

HRA Pharma Investigational Site 1013

New York, New York, United States

Site Status

HRA Pharma Investigational Site 1037

The Bronx, New York, United States

Site Status

HRA Pharma Investigational Site 1031

The Bronx, New York, United States

Site Status

HRA Pharma Investigational Site 1015

Burlington, North Carolina, United States

Site Status

HRA Pharma Investigational Site 1002

South Charleston, Ohio, United States

Site Status

HRA Pharma Investigational Site 1036

Lafayette Hill, Pennsylvania, United States

Site Status

HRA Pharma Investigational Site 1025

Philadelphia, Pennsylvania, United States

Site Status

HRA Pharma investigational site 1016

Clarksville, Tennessee, United States

Site Status

HRA Pharma Investigational Site 1022

Houston, Texas, United States

Site Status

HRA Pharma Investigational Site 1001

Houston, Texas, United States

Site Status

HRA Pharma investigational site 1024

Mapleton, Utah, United States

Site Status

HRA Pharma Investigational Site 1040

Salt Lake City, Utah, United States

Site Status

HRA Pharma Investigational Site 1021

Enumclaw, Washington, United States

Site Status

HRA Pharma Investigational site 1005

Seattle, Washington, United States

Site Status

HRA Pharma Investigational site 1010

Snohomish, Washington, United States

Site Status

Countries

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United States

Other Identifiers

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151042-004

Identifier Type: -

Identifier Source: org_study_id

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