Pilot Study for Speculum Free Cervical Cancer Screening

NCT ID: NCT04107181

Last Updated: 2025-03-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

305 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-04-14

Study Completion Date

2026-02-01

Brief Summary

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The objective of the work described in this protocol is to determine the optical signatures of cervical dysplasia using optical technologies.

Detailed Description

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This project is to assess if the introducer, "calla", can be used in place of a speculum during a routine Pap smear. For the patient arm, the introducer will be used in conjunction with standard of care procedures. The healthy volunteer arm will include taking the introducer home for a week to determine if each person can find their cervix without the help of a physician. As well as completing surveys on ease of use and demographics related to their medial history.

Conditions

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Cervical Cancer

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SCREENING

Blinding Strategy

NONE

Study Groups

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Patient surveillance

The introducer will be used during annual Pap smears for cervical cancer screening.

Group Type EXPERIMENTAL

Introducer "calla" device

Intervention Type DEVICE

The research introducer will be used after the patient consents prior to the annual pap smear.

Healthy Volunteers

There will be 2 types of healthy volunteers recruited to participate in this arm. The home study is to determine ease of use/feasibility of the introducer. The other group of healthy volunteers will be interviewed only. The goal of this study is to better understand how to improve women's health through learning about women's perceptions of their reproductive anatomy, specifically the cervix, comfort in discussing reproductive health topics with providers, and thoughts on two tools used to see the cervix.

Group Type EXPERIMENTAL

Interviews only

Intervention Type BEHAVIORAL

Healthy volunteer interviews

Interventions

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Introducer "calla" device

The research introducer will be used after the patient consents prior to the annual pap smear.

Intervention Type DEVICE

Interviews only

Healthy volunteer interviews

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

Healthy female

* Aged 21-65 years
* Have had a pelvic exam
* Have conversational proficiency in English
* Highest level of education attained

Exclusion Criteria

\- Pregnant women
Minimum Eligible Age

21 Years

Maximum Eligible Age

65 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Korle-Bu Teaching Hospital, Accra, Ghana

OTHER

Sponsor Role collaborator

National Cancer Institute (NCI)

NIH

Sponsor Role collaborator

Duke University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Nimmi Ramanujam, PhD

Role: PRINCIPAL_INVESTIGATOR

Duke

Locations

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Duke University

Durham, North Carolina, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Nimmi Ramanujam, PhD

Role: CONTACT

9196605307

Jennifer Gallagher, BA

Role: CONTACT

9199701551

Facility Contacts

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Nimmi Ramanujam, PhD

Role: primary

Jennifer Gallagher, BA

Role: backup

9199701551

Other Identifiers

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R01CA239268-04

Identifier Type: NIH

Identifier Source: secondary_id

View Link

Pro00008173_1

Identifier Type: -

Identifier Source: org_study_id

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