Basal Tumours in Bladder Cancer, Response to chemoTherapy

NCT ID: NCT04089748

Last Updated: 2025-06-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

293 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-02-27

Study Completion Date

2019-04-29

Brief Summary

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Determine the sensitivity/resistance to chemotherapy of the various subgroups of muscle-invasive bladder cancers, including the basal subgroup (about 25% of these tumours) according to 4 different classifications based on molecular or immunohistochemical classifiers.

Detailed Description

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Conditions

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Bladder Cancer Chemotherapy Effect

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Patients enrolled in VESPER study

Tumors from patient having muscle invasive bladder cancer who benefit from neoadjuvant chemotherapy with cisplatine included in VESPER cohort

neoadjuvant chemotherapy with cisplatine

Intervention Type COMBINATION_PRODUCT

Tumors from patient having muscle invasive bladder cancer who benefit from neoadjuvant chemotherapy with cisplatine

Patients from St Louis cohort not enrolled in VESPER study

Tumors from patient having muscle invasive bladder cancer who benefit from neoadjuvant chemotherapy with cisplatine included in Saint-Louis cohort

neoadjuvant chemotherapy with cisplatine

Intervention Type COMBINATION_PRODUCT

Tumors from patient having muscle invasive bladder cancer who benefit from neoadjuvant chemotherapy with cisplatine

Interventions

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neoadjuvant chemotherapy with cisplatine

Tumors from patient having muscle invasive bladder cancer who benefit from neoadjuvant chemotherapy with cisplatine

Intervention Type COMBINATION_PRODUCT

Eligibility Criteria

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Inclusion Criteria

Tumors from patient having muscle invasive bladder cancer who benefit from neoadjuvant chemotherapy with cisplatine included in VESPER cohort and :

* having signed an informed consent form for the participation to the collection or
* dead/lost to follow-up without prior opposition expressed against research program,
* genetic analysis will only be carried out for patients who have signed the genetic consent form.


Tumors from patient having muscle invasive bladder cancer who benefit from neoadjuvant chemotherapy with cisplatine included in Saint-Louis cohort and :

* having received an informed form for the participation to the collection and not having expressed opposition against research program within 1 month or
* dead/lost to follow-up without prior opposition expressed against research program,

Exclusion Criteria

-Patients enrolled in VESPER study:Tumors from patient having withdrawn his/her informed consent form for the participation to the collection and/or VESPER project.

OR

-Patients from St Louis not enrolled in VESPER study:Tumors from patient having expressed opposition against research program after 1 month for the participation to the collection.
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Institut Curie

OTHER

Sponsor Role collaborator

APHP

OTHER

Sponsor Role collaborator

University Hospital, Rouen

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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DRCI

Rouen, , France

Site Status

Countries

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France

Other Identifiers

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2016/384/HP

Identifier Type: -

Identifier Source: org_study_id

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