Acute Kidney Injury in Adult Patients Supported by VA-ECMO

NCT ID: NCT04082312

Last Updated: 2023-09-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

347 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-05-01

Study Completion Date

2019-07-05

Brief Summary

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Post-cardiotomy cardiogenic shock (PCCS) occurs in 2-6% of patients undergoing cardiac surgery, and 1% of cardiac surgery patients will require mechanical circulatory support using Veno-Arterial ExtraCorporeal Membrane Oxygenation (VA-ECMO). Acute Kidney Injury is a frequent complication in this population and negatively impacts the survival. We aimed to determine whether the timing of ECMO implantation influence the renal prognosis of these patients.

Detailed Description

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Conditions

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Acute Kidney Injury Cardiogenic Shock

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Group 1

Patients admitted in the surgical intensive care unit in post-operative of cardiac surgery between January 2013 and December 2016 + Assisted by VA-ECMO + with KDIGO stage 3 AKI

No intervention

Intervention Type OTHER

No intervention

Group 2

Patients admitted in the surgical intensive care unit in post-operative of cardiac surgery between January 2013 and December 2016 + Assisted by VA-ECMO + without KDIGO stage 3 AKI and alive at D10

No intervention

Intervention Type OTHER

No intervention

Group 3

Patients admitted in the surgical intensive care unit in post-operative of cardiac surgery between January 2013 and December 2016 + Assisted by VA-ECMO + died before D10 without KDIGO stage 3 AKI

No intervention

Intervention Type OTHER

No intervention

Interventions

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No intervention

No intervention

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* All patients admitted in post-operative of cardiac surgery
* Assisted by VA-ECMO

Exclusion Criteria

* Chronic hemodialysis
* Death occurring within the first 48 hours of VA-ECMO implantation
* Multiple VA-ECMO during the same hospitalization.
Minimum Eligible Age

18 Years

Maximum Eligible Age

99 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Groupe Hospitalier Pitie-Salpetriere

OTHER

Sponsor Role lead

Responsible Party

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Adrien Bouglé

Head of Surgical Intensive Care Unit

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Dr Adrien Bouglé

Paris, , France

Site Status

Countries

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France

References

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Lepere V, Duceau B, Lebreton G, Bombled C, Dujardin O, Boccara L, Charfeddine A, Amour J, Hajage D, Bougle A. Risk Factors for Developing Severe Acute Kidney Injury in Adult Patients With Refractory Postcardiotomy Cardiogenic Shock Receiving Venoarterial Extracorporeal Membrane Oxygenation. Crit Care Med. 2020 Aug;48(8):e715-e721. doi: 10.1097/CCM.0000000000004433.

Reference Type DERIVED
PMID: 32697513 (View on PubMed)

Other Identifiers

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AKI-ECMO

Identifier Type: -

Identifier Source: org_study_id

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