Microbial Composition of Breast Milk Collected From Healthy Turkish Women

NCT ID: NCT04072627

Last Updated: 2019-08-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-05-05

Study Completion Date

2019-07-05

Brief Summary

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Breast milk is an optimal source of nutrients for newborns as well as a potential source of bacteria for the intestinal microbiota. However, there are limited number of studies evaluating the relationship between maternal nutrition, breast milk and neonatal intestinal microbiota.

Detailed Description

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The study was conducted on a total of 20 healthy women following at Obstetrics and Gynecology Department of Gülhane Education and Research Hospital in Ankara Health Sciences University. Sociodemographic characteristics, anthropometric measurements, breastfeeding characteristics were evaluated in the third trimester of the women who underwent routine prenatal care. Breast milk samples were obtained at 16.day postpartum during lactation.

Conditions

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Microbial Community in Breast Milk

Study Design

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Observational Model Type

OTHER

Study Time Perspective

CROSS_SECTIONAL

Eligibility Criteria

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Inclusion Criteria

* Singleton pregnancy
* Age 19-35 years
* At weeks of 30-36 gestation
* No history of acute or chronic diseases
* Term delivery

Exclusion Criteria

* Alcohol use
* Smoking
* Gestational diabetes
* Type 1 and 2 diabetes
* Preeclampsia
* Polycystic ovary
* Syndrome
* Thyroid and parathyroid disease
* Metabolic bone or kidney disease
* Abnormal liver function
* Multiple pregnancy
* Premature and postmature labor
* Having chemotherapy
* Taking drugs such as antibiotics and probiotics
Minimum Eligible Age

20 Years

Maximum Eligible Age

31 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Turkish Society of Clinical Enteral and Parenteral Nutrition

OTHER

Sponsor Role collaborator

Hacettepe University

OTHER

Sponsor Role lead

Responsible Party

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F. Gülhan Samur

Prof. Dr.

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Gülhan SAMUR, Professor

Role: PRINCIPAL_INVESTIGATOR

Hacettepe University

Locations

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Hacettepe University

Ankara, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

References

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Murphy K, Curley D, O'Callaghan TF, O'Shea CA, Dempsey EM, O'Toole PW, Ross RP, Ryan CA, Stanton C. The Composition of Human Milk and Infant Faecal Microbiota Over the First Three Months of Life: A Pilot Study. Sci Rep. 2017 Jan 17;7:40597. doi: 10.1038/srep40597.

Reference Type RESULT
PMID: 28094284 (View on PubMed)

Fitzstevens JL, Smith KC, Hagadorn JI, Caimano MJ, Matson AP, Brownell EA. Systematic Review of the Human Milk Microbiota. Nutr Clin Pract. 2017 Jun;32(3):354-364. doi: 10.1177/0884533616670150. Epub 2016 Sep 27.

Reference Type RESULT
PMID: 27679525 (View on PubMed)

Jost T, Lacroix C, Braegger C, Chassard C. Assessment of bacterial diversity in breast milk using culture-dependent and culture-independent approaches. Br J Nutr. 2013 Oct;110(7):1253-62. doi: 10.1017/S0007114513000597. Epub 2013 Mar 14.

Reference Type RESULT
PMID: 23507238 (View on PubMed)

Hunt KM, Foster JA, Forney LJ, Schutte UM, Beck DL, Abdo Z, Fox LK, Williams JE, McGuire MK, McGuire MA. Characterization of the diversity and temporal stability of bacterial communities in human milk. PLoS One. 2011;6(6):e21313. doi: 10.1371/journal.pone.0021313. Epub 2011 Jun 17.

Reference Type RESULT
PMID: 21695057 (View on PubMed)

Chen PW, Lin YL, Huang MS. Profiles of commensal and opportunistic bacteria in human milk from healthy donors in Taiwan. J Food Drug Anal. 2018 Oct;26(4):1235-1244. doi: 10.1016/j.jfda.2018.03.004. Epub 2018 Apr 5.

Reference Type RESULT
PMID: 30249322 (View on PubMed)

Damaceno QS, Souza JP, Nicoli JR, Paula RL, Assis GB, Figueiredo HC, Azevedo V, Martins FS. Evaluation of Potential Probiotics Isolated from Human Milk and Colostrum. Probiotics Antimicrob Proteins. 2017 Dec;9(4):371-379. doi: 10.1007/s12602-017-9270-1.

Reference Type RESULT
PMID: 28374172 (View on PubMed)

Other Identifiers

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Hacettepe Nutrition Diet

Identifier Type: -

Identifier Source: org_study_id

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