Minimally Invasive Locking Plate Fixation vs Reamed Intramedullary Nail Fixation on Patients With Open Tibia Fracture

NCT ID: NCT04072094

Last Updated: 2020-05-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

300 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-06-30

Study Completion Date

2025-06-30

Brief Summary

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The best treatment for the open tibia fractures remains controversial. It is unknown whether minimally invasive locking plate or reamed intramedullary nail fixation will result in lower complication rates and better function.

Detailed Description

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The best fixation method for open tibial fractures remains controversial. The current standard treatment options recommended the use of intramedullary nail for treating such fractures. Recent studies also showed favorable results for the use of plates in managing open tibial fractures. However, it is unknown whether locking plate or intramedullary nail fixation will result in lower complication rates and better function.

This study is a prospective, randomized trial to compare the safety and efficiency of minimally invasive plate osteosynthesis and reamed intramedullary nails in treating type I-II open tibial shaft fractures. The investigators hypothesize that neither intervention resulted in a superior disability rating at 12 months. Outcomes evaluated will include the rate of infection, the number of re-hospitalization for the complication, the time to bone healing, Patient-Reported outcome and quality of life and other complications.

Conditions

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Open tíbia Fracture

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Minimally Invasive Locking Plate Fixation

Patients randomized to the Minimally Invasive Locking Plate Fixation arm will be treated with plate fixation. The plate may be applied in a percutaneous fashion. Any combination of locked and/or non-locked screws may be used.

Group Type EXPERIMENTAL

Minimally Invasive Locking Plate Fixation

Intervention Type PROCEDURE

Patients randomized to the Minimally Invasive Locking Plate Fixation arm will be treated with plate fixation. The plate may be applied in a percutaneous fashion. Any combination of locked and/or non-locked screws may be used.

Intramedullary Nail Fixation

Patients randomized to the Intramedullary Nail Fixation arm will be receive a standard locked intramedullary nail fixation. The nail must use at least one static interlock proximal to and one static interlock distal to the fracture site. The nail may be placed with a reamed technique.

Group Type ACTIVE_COMPARATOR

Intramedullary Nail Fixation

Intervention Type PROCEDURE

Patients randomized to the Intramedullary Nail Fixation arm will be receive a standard locked intramedullary nail fixation. The nail must use at least one static interlock proximal to and one static interlock distal to the fracture site. The nail may be placed with a reamed technique.

Interventions

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Minimally Invasive Locking Plate Fixation

Patients randomized to the Minimally Invasive Locking Plate Fixation arm will be treated with plate fixation. The plate may be applied in a percutaneous fashion. Any combination of locked and/or non-locked screws may be used.

Intervention Type PROCEDURE

Intramedullary Nail Fixation

Patients randomized to the Intramedullary Nail Fixation arm will be receive a standard locked intramedullary nail fixation. The nail must use at least one static interlock proximal to and one static interlock distal to the fracture site. The nail may be placed with a reamed technique.

Intervention Type PROCEDURE

Other Intervention Names

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Locking Plate Fixation

Eligibility Criteria

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Inclusion Criteria

* Ages 18 - 60 years inclusive
* Open diaphyseal fracture
* Gustilo-Anderson Type I, II, IIIA

Exclusion Criteria

* Closed, periarticular or pathological fracture
* Gustilo-Anderson Type IIIB,IIIC
* Patients with concomitant fractures in the ipsilateral limb
* The patient is unable to medically tolerate general anesthesia
* The patient is unable to provide informed consent or comply with completing questionnaires
* Tibia already infected as diagnosed by a surgeon
* The patient has been diagnosed with a severe psychiatric condition
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Taizhou Hospital

OTHER

Sponsor Role collaborator

Ningbo No.2 Hospital

OTHER

Sponsor Role collaborator

The First People's Hospital of Huzhou

OTHER

Sponsor Role collaborator

Second Affiliated Hospital, School of Medicine, Zhejiang University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Central Contacts

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Zhao-ming Ye, MD

Role: CONTACT

+86-571-87783553

Ling-ling Sun, MD

Role: CONTACT

+86-571-87783553

Other Identifiers

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z2gk

Identifier Type: -

Identifier Source: org_study_id

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