Adaptive CT Acquisition for Personalised Thoracic Imaging

NCT ID: NCT04070586

Last Updated: 2021-05-19

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 30 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2019-08-21
• Study Completion Date: 2021-02-19

Brief Summary

In this trial, Respiratory Motion Guided (RMG) 4DCBCT will be implemented for the first time on lung cancer patients. RMG-4DCBCT adapts the image acquisition as the patient's breathing changes (i.e. if the patient breathes faster, imaging data is acquired faster).

By adapting the acquisition to the dynamic patient, personalised images of a patients lungs are able to be acquired for radiotherapy treatments.

Detailed Description

Four dimensional cone beam computed tomography (4DCBCT) continues to play a pivotal role in the safe delivery of radiotherapy treatments for lung cancer patients. 4DCBCT meets exacting tumour localisation requirements by allowing radiation therapists to measure the tumour as a patient breathes (4D=volumetric images plus respiratory induced tumour motion). Despite the success of 4DCBCT to date, it suffers from relatively poor image quality, very long scan times (4min) and higher imaging doses than are necessary. The primary reason for these problems is that although the purpose of 4DCBCT is to acquire information about tumour motion due to respiration, there is no feedback from the patients breathing signal to adapt and optimise the image acquisition process. This clinical trial is a phase 1 first in human's pilot study and the aim is therefore to prove feasibility of RMG-4DCBCT, not necessarily efficacy. As such, patient scans will be acquired across a broad range of patient breathing conditions to optimise the RMG-4DCBCT technique and also to plan a hypothesis driven clinical trial to follow.

Conditions

Cancer, Lung

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

4DCBCT images

4DCBCT images are acquired and assessed offline.

4DCBCT images

Intervention Type: DEVICE

Images are acquired and assessed offline

Interventions

4DCBCT images

Images are acquired and assessed offline

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• Have the ability to give informed consent
• A diagnosis of lung cancer with an indication for radiotherapy either curative or palliative
• Radiotherapy treatment involving the routine acquisition of CBCT for patient setup provided that 4DCBCT is to be acquired during the course of treatment.
• At least two radiotherapy fractions during the course of treatment.

Exclusion Criteria

• Pregnant women.
• Patient who in the opinion of the treating physician could not tolerate the extra time on the treatment couch for two days of treatment.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

National Health and Medical Research Council, Australia

OTHER

Sponsor Role: collaborator

Liverpool Cancer Therapy Centre

OTHER_GOV

Sponsor Role: collaborator

University of Sydney

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Ricky O'Brien, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Sydney

Locations

Liverpool Hospital

Liverpool, New South Wales, Australia

Countries

Australia

References

Lau BKF, Reynolds T, Keall PJ, Sonke JJ, Vinod SK, Dillon O, O'Brien RT. Reducing 4DCBCT imaging dose and time: exploring the limits of adaptive acquisition and motion compensated reconstruction. Phys Med Biol. 2022 Mar 7;67(6). doi: 10.1088/1361-6560/ac55a4.

Reference Type: DERIVED

PMID: 35172286 (View on PubMed)

Other Identifiers

HREC/18/LPOOL/361

Identifier Type: -

Identifier Source: org_study_id