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Xenon-enhanced Ventilation CT-guided Radiotherapy for Lung Cancer Treatment

NCT ID: NCT05134558

Last Updated: 2021-11-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-02-04

Study Completion Date

2024-12-31

Brief Summary

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The investigators aim to use xenon-enhanced ventilation computed tomography (CT) to design personalized functional lung avoidance radiotherapy for lung cancer patients who are scheduled to receive lung radiation therapy. The investigators' goal is to optimally protect the lung function of the patients and reduce the incidence of radiation pneumonitis.

Detailed Description

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There has been an increase in the application of radiation therapy in the treatment of lung tumors; however, the associated side effect, called radiation pneumonitis, can significantly reduce lung function and the quality of life of patients, eventually leading to fatal consequences. The investigators aim to use xenon-enhanced ventilation computed tomography (CT) to design personalized functional lung avoidance radiotherapy for lung cancer patients who are scheduled to receive lung radiation therapy. The investigators' goal is to optimally protect the lung function of the patients and reduce the incidence of radiation pneumonitis.

Conditions

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Lung Cancer Radiation Therapy Complication

Keywords

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lung cancer Radiation Therapy Xenon-enhanced ventilation CT

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Xenon-enhanced Ventilation CT-guided Radiotherapy

Patients will be receiving Xenon-enhanced Ventilation CT-guided Radiotherapy for functional lung avoidance. The doses for the tumors, lungs, and organs at risk will be examined and evaluated.

Group Type EXPERIMENTAL

Xenon-enhanced Ventilation CT-guided Radiotherapy

Intervention Type RADIATION

Xenon-enhanced Ventilation CT-guided Radiotherapy for functional protection of the lung

Interventions

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Xenon-enhanced Ventilation CT-guided Radiotherapy

Xenon-enhanced Ventilation CT-guided Radiotherapy for functional protection of the lung

Intervention Type RADIATION

Eligibility Criteria

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Inclusion Criteria

* Patients aged 20-80 years, with lung cancer receiving thoracic radiotherapy in NTUH, from February 2020 to December 2024.

Exclusion Criteria

* The age is less than 20 years old or older than 80 years old.
* Unstable clinical condition, unable to maintain apnea for 15 second, and history of prior adverse reaction to xenon.
* Renal insufficiency patients.
* Claustrophobia
* Those who are pregnant.
Minimum Eligible Age

20 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Taiwan University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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National Taiwan University Hospital

Taipei, , Taiwan

Site Status RECRUITING

Countries

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Taiwan

Central Contacts

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Yu-Sen Huang, Md PhD

Role: CONTACT

Phone: +886-23123456

Email: [email protected]

Facility Contacts

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Yu-Sen Huang, MD PhD

Role: primary

Other Identifiers

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201912128RIN

Identifier Type: -

Identifier Source: org_study_id