ePRO for Adjuvant Therapy of Colorectal Adenocarcinoma

NCT ID: NCT04069455

Last Updated: 2021-09-17

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 270 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2019-10-01
• Study Completion Date: 2024-09-30

Brief Summary

It is a multi-centric randomized controlled trial. The goal of this study is to observe the improvement of QoL using ePRO to manage patients with colorectal cancer who received Oxaliplatin-based adjuvant chemotherapy.The prognosis will also be studied.

Detailed Description

The most of advanced colorectal carcinoma are underwent postoperative chemotherapy. Adverse events (AE) during chemotherapy disrupt treatment and impair the patients' quality of life(QoL). Under usual care, the patients are largely required to self-monitor symptoms at home. Patients can lack confidence in making decisions between obtaining clinical support or self-managing and can delay seeking medical advice, heightening the risk of symptom escalation and hospital admissions and impact the efficacy of chemotherapy finally. There is growing evidence that the utilisation of patient-reported outcome(PRO) measures can aid the timely identification of physical and psychosocial disorders, facilitate patient-doctor communication and assist decision-making. There has been a drive to develop electronic systems(ePRO) to allow remote real-time patient monitoring during cancer therapy. Positive patient benefit (including QOL and survival) was recently reported in a US trial of an online system for metastatic cancer treatment.

The trial is a prospective randomised two-arm parallel group design study with repeated measures and mixed methods. Participants (adult patients with colorectal cancer on adjuvant chemotherapy) are randomised to receive the ePRO intervention or usual care over 24 weeks of treatment. Participants in the intervention arm receive training in using the ePRO APP system to provide routine weekly adverse event reports from home. Hospital staff can access ePRO reports via APP and use the information during consultations or phone calls or message with patients. The overall target sample for the trial is N = 270. The primary outcome of is quality of life (EORTC QLQ-C30/CR29) with secondary outcomes including the proportion of completed chemotherapy, AE, DFS, OS and patient self-efficacy. Outcome data is collected at baseline, 3, 6 and 12 months. The intervention is also being evaluated via end of study interviews with patient participants and clinical staff.

Conditions

Colorectal Carcinoma

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: HEALTH_SERVICES_RESEARCH
• Blinding Strategy: SINGLE

Study Groups

EPRO group

Clinical usual care plus ePRO App self-management online during postoperative adjuvant chemotherapy

Group Type: EXPERIMENTAL

Electronic Patients Reported Outcomes

Intervention Type: OTHER

ePRO is a application which is web based and accessible from home or mobile device, for patients to complete symptom reports and receive severity-based advice

Control group

Clinical usual care during postoperative adjuvant chemotherapy

Group Type: NO_INTERVENTION

No interventions assigned to this group

Interventions

Electronic Patients Reported Outcomes

ePRO is a application which is web based and accessible from home or mobile device, for patients to complete symptom reports and receive severity-based advice

Intervention Type: OTHER

Other Intervention Names

ePRO

Eligibility Criteria

Inclusion Criteria

1. 18 to 75 years old (inclusive), regardless of gender.

2. Patients with colorectal cancer diagnosed by cytology or histopathology.

3. The patient underwent radical surgery for cancer. Radical surgery is defined as routine laparotomy or laparoscopic radical surgery for the purpose of radical

4. The ECOG performance status is 0 to 2 points and able to receive adjuvant chemotherapy.

5. Patients must be randomized within 2 months after the surgery.

6. According to the investigator's judgment, the patient has recovered from surgical side effects after radical surgery (e.g., the wound has healed fully without complications).

7. Oxaliplatin regimen is planned to be used for postoperative adjuvant chemotherapy for 3 to 6 months

8. The blood pregnancy test results of women of childbearing age must be negative within 7 days prior to randomization.

9. The main organs function well. That is, the relevant inspection indexes within 14 days prior to enrollment meet the following requirements:

a) Routine blood test: i. Leukocyte≥ 4.0×109/L; ii. Neutrophil count > 1.5×109/L; iii. Blood platelet count > 80×109/L; iv. Hemoglobin > 90 g/L (No blood transfusion in 14 days); b) Biochemistry test: i. TBil ≤ 1.5×ULN (upper limit of normal); ii. Blood glutamic alanine aminotransferas (ALT) or serum aspartate aminotransferase (AST) ≤ 2.5×ULN; iii. Endogenous creatinine clearance rate ≥ 60 ml/min (Cockcroft-Gault formula); c) Cardiac doppler ultrasound evaluation: left ventricular ejection fraction (LVEF) ≥ 50%.

10. The patient has provided written informed consent prior to any study-specific procedures, and is willing and able to be present during the study and follow the study procedure during treatment and follow-up.

Exclusion Criteria

1. <18 years old or >75 years old.

2. Other tumors except gastric and colorectal cancer.

3. Metastasis has occurred.

4. Female during pregnancy or lactation.

5. A history of other malignant tumors within 5 years, except for adequately treated basal cell carcinoma or squamous cell carcinoma or carcinoma in situ.

6. The patient is known to be allergic to oxaliplatin, 5-FU, folinic acid or any excipients of these products.

7. Evidence of any severe or uncontrolled systemic disease, including but not limited to:

1. Unstable or decompensated respiratory, cardiac, liver or kidney disease;

2. HIV infection;

3. Uncontrol high blood pressure, diabetes;

4. Severe arrhythmia;

5. Massive active bleeding.

8. A history of alcohol abuse or drug abuse.

9. As judged by the investigator, there is a low likelihood of enrollment (including inability to understand study requirements, poor compliance, infirmity, inability to ensure that the protocol can be followed as required, etc.), or there are other factors considered by the investigator to be unsuitable for this study.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Zhejiang University

OTHER

Sponsor Role: lead

Responsible Party

Ding Ke-Feng

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Kefeng Ding, MD

Role: PRINCIPAL_INVESTIGATOR

Second Affiliated Hospital, Zhejiang University School of Medicine

Locations

GuoXiang Cai

Shanghai, Shanghai Municipality, China

Site Status: RECRUITING

Countries

China

Central Contacts

Lifeng Sun, MD

Role: CONTACT

sunlifeng@zju.edu.cn

+86-571-87783583

kefeng Ding, MD

Role: CONTACT

Dingkefeng@zju.edu.cn

+86-571-87783583

Facility Contacts

GuoXiang Cai, MD

Role: primary

gxcai@fudan.edu.cn

Other Identifiers

CRCCZ-ePRO2

Identifier Type: -

Identifier Source: org_study_id