Acute Effect of modeRate-intensity aerOBIc Exercise on Colon Cancer Cell Growth

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

16 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-09-23

Study Completion Date

2020-09-30

Brief Summary

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This study involves drawing blood samples from men before and after they perform 30-minutes of moderate-intensity aerobic exercise. The investigators will evaluate whether adding the exercise serum to colon cancer cells in a dish can reduce the growth of the cells compared to the resting serum.

Note: serum is the liquid part of the blood that carries hormones and metabolites around the body.

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Detailed Description

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Regular exercise is associated with a reduced risk of developing colon cancer. However, the mechanisms underpinning the anti-cancer effect of exercise are not yet fully understood. A recent theory suggests that each time you exercise, the short-lasting spikes in circulating hormones can suppress the growth of cancer cells. Hence, every exercise bout could have a direct anti-cancer effect.

This study will recruit men with an increased of colon cancer and explore whether incubating colon cancer cells with serum collected after a bout of moderate-intensity aerobic exercise influences cell viability in vitro.

Conditions

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Colon Adenocarcinoma Colon Cancer

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

This is a randomised, counterbalanced, crossover study whereby all participants will complete an exercise assessment and a resting assessment in a randomised order.

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

It is not possible to blind participants nor investigators. Investigators will be blind to allocation order until after the first blood sample is drawn.

Study Groups

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Exercise assessment

The exercise condition will involve venous blood samples being drawn immediately before and after a single bout of moderate-intensity aerobic interval exercise.

Group Type EXPERIMENTAL

Exercise assessment

Intervention Type OTHER

The moderate-intensity aerobic interval exercise will be performed on a cycle ergometer under the supervision of trained staff in an exercise science laboratory. Participants will perform a 5 to 10-minute warm-up that begins by pedalling against a light resistance (60 W) and progressively increases in resistance until a target heart rate of 50-60% heart rate reserve is achieved. Participants will then complete 6 x 5-minute bouts at 60% heart rate reserve whilst maintaining a cadence of 60 rev·min-1, separated by 2.5-minutes of pedalling against light resistance (60 W). The session will finish with a cool-down at light resistance (60 W) lasting 10-minutes.

Resting assessment

The resting condition will involve venous blood samples being drawn before and after 60 minutes of seated rest.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Exercise assessment

The moderate-intensity aerobic interval exercise will be performed on a cycle ergometer under the supervision of trained staff in an exercise science laboratory. Participants will perform a 5 to 10-minute warm-up that begins by pedalling against a light resistance (60 W) and progressively increases in resistance until a target heart rate of 50-60% heart rate reserve is achieved. Participants will then complete 6 x 5-minute bouts at 60% heart rate reserve whilst maintaining a cadence of 60 rev·min-1, separated by 2.5-minutes of pedalling against light resistance (60 W). The session will finish with a cool-down at light resistance (60 W) lasting 10-minutes.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Age ≥ 50 years
* BMI ≥ 25 kg/m2 and/or waist circumference of ≥ 94 cm
* Male
* Participating in less than 30 min of planned, structured, moderate to vigorous-intensity physical activity on three or more d·wk-1 for the last three months

Exclusion Criteria

* Any absolute or relative contraindication to exercise testing, as determined by the American College of Sports Medicine
* Any sign/symptom of cardiovascular, metabolic or renal disease
* Known cardiovascular, metabolic or renal disease without written medical clearance from physician
* Resting hypertension (≥160 mmHg systolic and/or ≥90 mmHg diastolic)
* Chronic obstructive pulmonary disease and/or asthma with peak respiratory flow \< 300 l/min
* Previous stroke or transient ischemic attack
* Epilepsy or aneurysm (large vessel or cerebral)
* Previous or current treatment for malignancy
* Clotting disorder
* Taking beta-adrenergic blocking agents
* Resting heart rate ≥ 100 bpm
* Musculoskeletal, neurological, anthropometric, or rheumatoid conditions that makes it not possible to pedal a bicycle and/or would be worsened due to exercise
* Body mass \> 150 kg

Minimum Eligible Age

50 Years

Maximum Eligible Age

90 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes