Epidemiologic Patterns of Bacteremia After Trauma

NCT ID: NCT04042636

Last Updated: 2019-08-02

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 859 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2011-01-01
• Study Completion Date: 2018-12-31

Brief Summary

Presence of pelvic and liver injury on arrival in ED, gastrointestinal tract perforation and massive transfusion within the first 24 hours after trauma appear a significant risk factor for bacteremia. Scoring with the ISS, intra-abdominal and pelvic injury and presence of transfusion and shock at admission to ED appears a useful tool for identifying trauma patients at increased risk of bacteremia.

Detailed Description

Purpose: Bacteremia is a major nosocomial infection problem in view of its high mortality. Bacteremia occurs in trauma patients frequently and increases a morbidity and mortality. The aim of this study was to identify risk factors and to describe epidemiological patterns for early onset (EOB) and late onset (LOB) bacteremia after trauma.

Methods: All trauma patients admitted to surgical intensive care unit (SICU) and general ward (GW) from January 2011 to December 2015 were retrospectively enrolled. The following information was collected for each patient and recorded in a computer database: demography, severity of trauma according to the Injury Severity Score (ISS) and each abbreviated injury score (AIS), severity of coma according to the Glasgow Coma Scale (GCS), presence of shock and transfusion. Early onset bacteremia was defined as EOB when onset occurred within 7 days after trauma, and late onset bacteremia was defined as LOB when appearing after 7 days from trauma.

Conditions

Bacteremia

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

1

Patients with Bacteremia after trauma

No interventions assigned to this group

2

Patients with non-bacteremia after trauma

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• The patients who admitted to intensive care unit (ICU) or general ward (GW) through the emergency department after trauma were studied

Exclusion Criteria

• Patients who arrived on dead-on arrival

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Asan Medical Center

OTHER

Sponsor Role: lead

Responsible Party

Suk-Kyung

professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Hakjae Lee

Seoul, , South Korea

Countries

South Korea

References

Rello J, Ricart M, Mirelis B, Quintana E, Gurgui M, Net A, Prats G. Nosocomial bacteremia in a medical-surgical intensive care unit: epidemiologic characteristics and factors influencing mortality in 111 episodes. Intensive Care Med. 1994;20(2):94-8. doi: 10.1007/BF01707661.

Reference Type: RESULT

PMID: 8201105 (View on PubMed)

Antonelli M, Moro ML, D'Errico RR, Conti G, Bufi M, Gasparetto A. Early and late onset bacteremia have different risk factors in trauma patients. Intensive Care Med. 1996 Aug;22(8):735-41. doi: 10.1007/BF01709514.

Reference Type: RESULT

PMID: 8880240 (View on PubMed)

Menges P, Kessler W, Kloecker C, Feuerherd M, Gaubert S, Diedrich S, van der Linde J, Hegenbart A, Busemann A, Traeger T, Cziupka K, Heidecke CD, Maier S. Surgical trauma and postoperative immune dysfunction. Eur Surg Res. 2012;48(4):180-6. doi: 10.1159/000338196. Epub 2012 May 25.

Reference Type: RESULT

PMID: 22653168 (View on PubMed)

Niven DJ, Fick GH, Kirkpatrick AW, Grant V, Laupland KB. Cost and outcomes of nosocomial bloodstream infections complicating major traumatic injury. J Hosp Infect. 2010 Dec;76(4):296-9. doi: 10.1016/j.jhin.2010.06.004. Epub 2010 Aug 11.

Reference Type: RESULT

PMID: 20705364 (View on PubMed)

Other Identifiers

AsanMC-Bacteremia

Identifier Type: -

Identifier Source: org_study_id