The Effect of Periradial Injection of Papaverine Versus Nitroglycerine on Radial Artery Diameter

NCT ID: NCT04030663

Last Updated: 2020-09-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

EARLY_PHASE1

Total Enrollment

90 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-02-05

Study Completion Date

2019-09-02

Brief Summary

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Compare the effect of periradial injection of papaverine versus nitroglycerine on radial artery diamter before cannulation of it in cardiac surgery.

Detailed Description

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we want in this study to facilitate radial artery canulation and decrease the number of attemps of puncture which may lead to disappearance of the pulse.

The aim of this study is to compare the effect of adding papaverine to local anesthetic xylocaine versus adding nitroglycerine to it on the diameter and palpability of radial artery and if perioperative spasm will decrease significantly with one of these methods.

Conditions

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Radial Artery Injury Prevetion

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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papaverine

Group Type ACTIVE_COMPARATOR

papaverine

Intervention Type DRUG

periradial injection of one of three drugs prior to cannulation of radial artery by 20 minutes and mesure the diamter of it by ultrasound

nitroglycerine

Group Type ACTIVE_COMPARATOR

nitroglycerine

Intervention Type DRUG

periradial injection of one of three drugs prior to cannulation of radial artery by 20 minutes and mesure the diamter of it by ultrasound

xlyocaine

Group Type PLACEBO_COMPARATOR

xlyocaine

Intervention Type DRUG

periradial injection of one of three drugs prior to cannulation of radial artery by 20 minutes and mesure the diamter of it by ultrasound

Interventions

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papaverine

periradial injection of one of three drugs prior to cannulation of radial artery by 20 minutes and mesure the diamter of it by ultrasound

Intervention Type DRUG

nitroglycerine

periradial injection of one of three drugs prior to cannulation of radial artery by 20 minutes and mesure the diamter of it by ultrasound

Intervention Type DRUG

xlyocaine

periradial injection of one of three drugs prior to cannulation of radial artery by 20 minutes and mesure the diamter of it by ultrasound

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

\- Patients who will be included in the study are those scheduled for elective cardiac surgery who are hemodynamically stable.

Exclusion Criteria

* Any patient with negative modified Allen test, atrioventricular block, glaucoma, altered liver function, unstable hemodynamics, emergency surgeries, and peripheral vascular disease.
Minimum Eligible Age

20 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Kasr El Aini Hospital

OTHER

Sponsor Role lead

Responsible Party

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ahmed said

lecture of anesthesia

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Faculty of Medicine

Cairo, Benisuef, Egypt

Site Status

Countries

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Egypt

Other Identifiers

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FWA00015574

Identifier Type: -

Identifier Source: org_study_id

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