Influence of Socio-Economic Factor on Net Survival in Patients With Multiple Sclerosis in France ( ECOVIMUS).
NCT ID: NCT04028232
Last Updated: 2020-01-23
Study Results
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Basic Information
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UNKNOWN
30000 participants
OBSERVATIONAL
2019-07-10
2020-12-31
Brief Summary
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Objective: The main objective of ECOVIMUS is to estimate net survival according to SES using the European Deprivation Index as a proxy and other major covariates (gender, initial clinical phase and years of disease onset).
Methods: In order to answer to our main objective, we will use a retrospective cohort of MS patients with a medical follow-up in one of the 18 centers included in SURVIMUS II, with a MS onset between 1960 and 2015 and with an informed vital at the date of December 31st, 2015.
The ecological score of deprivation EDI will be used as a proxy of the socioeconomic status and will be attributed from the geolocalisation to patient's residence address. Net survival is directly associated to the notion of "mortality in excess". This mortality will be estimated comparing the observed mortality in MS patients to mortality in the general population. The advantage of this methodological approach is that cause of death is not needed.
Statistical analysis: The influence of socioeconomic status on the excess of mortality will be estimated thanks to a parametric multivariate model of excess rate mortality. This model will be adjusted on other major covariates (gender, age at disease onset, and initial clinical phase) and will include potential complex effects as non-linearity, non-proportionality and interactions.
Expected results: We expect to highlight some differences of net survival in MS patients according to socioeconomic group as it was already shown in cancers. This study will complete information on factors of mortality excess in MS and knowledge on socioeconomic inequalities encountered all along MS disease course.
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Detailed Description
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Conditions
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Study Design
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COHORT
OTHER
Eligibility Criteria
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Inclusion Criteria
* Diagnosis a of definite or probably MS according to Poser or McDonald criteria. With an MS onset date between January 1st, 1960 and December 31st, 2015.
* With a postal residence address well informed in the OFSEP database.
Exclusion Criteria
1 Year
100 Years
ALL
No
Sponsors
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Ecole des Hautes Etudes en Santé Publique
OTHER
Hospices Civils de Lyon
OTHER
University Hospital, Caen
OTHER
Responsible Party
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Locations
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University Hospital Center of CAEN
Caen, Normandy, France
University Hospital of Besancon
Besançon, , France
University Hospital of Bordeaux
Bordeaux, , France
University Hospital Centre of Caen
Caen, , France
University Hospital of Clermont Ferrand
Clermont-Ferrand, , France
University Hospital of Dijon
Dijon, , France
University Hospital of Lille
Lille, , France
University Hospital of Lyon
Lyon, , France
University Hospital of Marseille
Marseille, , France
University Hospital of Montpellier
Montpellier, , France
University Hospital of Nancy
Nancy, , France
University Hospital of Nantes
Nantes, , France
University Hospital of Nice
Nice, , France
University hospital Centre of Nîmes
Nîmes, , France
University Hospital of Rennes
Rennes, , France
University Hospital Centre of Saint-Etienne
Saint-Etienne, , France
University Hospital of Strasbourg
Strasbourg, , France
University Hospital Centre of Toulouse
Toulouse, , France
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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18512
Identifier Type: -
Identifier Source: org_study_id
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