The Emotional Impact of Surveillance for Pancreatic Cancer

NCT ID: NCT04024345

Last Updated: 2020-03-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

150 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-07-01

Study Completion Date

2021-12-31

Brief Summary

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Due to its rarity a population screening program for pancreatic cancer is not possible. For this reason, considering background data on genetic predisposition and familiarity for this lethal tumor, efforts have been pushed to build up surveillance programs for subjects at high-risk of pancreatic cancer, due to familiarity and/or genetic predisposition. These programs are based on radiological examinations (such as MRI or endoultrasonography) and laboratory tests. However, little is known about the psychological burden of these programs. Only a handful of studies investigated, in various ways, how the participation in surveillance programs for pancreatic cancer may burden the psychological status, with a consequent possible impairment of the psychological wellbeing, and a higher risk of withdraw from the surveillance program itself. The aim of this study was to assess the psychological and emotional impact in high-risk individuals participating in a surveillance program for pancreatic cancer due to familiarity and/or to genetic predisposition, using specific psychological tools, such as multiple psychological questionnaires, investigating different functioning areas, administered by a clinical psychologist.

Detailed Description

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Conditions

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Pancreatic Cancer Psychological Distress

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Psychometric assessment group

Arms to whom the psychometric assessment will be administered

Group Type EXPERIMENTAL

Barratt Simplified Measure of Social Status (BSMSS)

Intervention Type DIAGNOSTIC_TEST

Questionnaire that evaluates cultural identity, educational level and occupation of the subject and the subject's parents and spouse (if any)

Global Assessment of Functioning scale (GAF)

Intervention Type DIAGNOSTIC_TEST

Used to measure overall levels of functionality of an individual

General Self-Efficacy Scale (GSES)

Intervention Type DIAGNOSTIC_TEST

Psychometric scale that is designed to assess optimistic self-beliefs to cope with a variety of difficult demands in life

Perceived Stress Scale (PSS)

Intervention Type DIAGNOSTIC_TEST

To assess the perceived stress

Coping Orientation to Problems Experienced (Brief COPE),

Intervention Type DIAGNOSTIC_TEST

It evaluates the subject's coping style through investigation of problem-solving abilities and emotional fluctuation, as a response to stressful situations

Multidimensional Scale of Perceived Social Support (MSPSS)

Intervention Type DIAGNOSTIC_TEST

to explore the subject's social support system

Interventions

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Barratt Simplified Measure of Social Status (BSMSS)

Questionnaire that evaluates cultural identity, educational level and occupation of the subject and the subject's parents and spouse (if any)

Intervention Type DIAGNOSTIC_TEST

Global Assessment of Functioning scale (GAF)

Used to measure overall levels of functionality of an individual

Intervention Type DIAGNOSTIC_TEST

General Self-Efficacy Scale (GSES)

Psychometric scale that is designed to assess optimistic self-beliefs to cope with a variety of difficult demands in life

Intervention Type DIAGNOSTIC_TEST

Perceived Stress Scale (PSS)

To assess the perceived stress

Intervention Type DIAGNOSTIC_TEST

Coping Orientation to Problems Experienced (Brief COPE),

It evaluates the subject's coping style through investigation of problem-solving abilities and emotional fluctuation, as a response to stressful situations

Intervention Type DIAGNOSTIC_TEST

Multidimensional Scale of Perceived Social Support (MSPSS)

to explore the subject's social support system

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Being enrolled in the Institutional surveillance program for pancreatic cancer
* Ability to understand the details and implications of a study protocol.

Exclusion Criteria

* None
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Azienda Ospedaliera Universitaria Integrata Verona

OTHER

Sponsor Role lead

Responsible Party

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Erica Secchettin

Institutional Project Manager

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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University Hospital of Verona

Verona, VR, Italy

Site Status

Countries

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Italy

References

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Maheu C, Vodermaier A, Rothenmund H, Gallinger S, Ardiles P, Semotiuk K, Holter S, Thayalan S, Esplen MJ. Pancreatic cancer risk counselling and screening: impact on perceived risk and psychological functioning. Fam Cancer. 2010 Dec;9(4):617-24. doi: 10.1007/s10689-010-9354-5.

Reference Type RESULT
PMID: 20623197 (View on PubMed)

Konings IC, Harinck F, Kuenen MA, Sidharta GN, Kieffer JM, Aalfs CM, Poley JW, Smets EM, Wagner A, van Rens A, Vleggaar FP, Ausems MG, Fockens P, van Hooft JE, Bruno MJ, Bleiker EM; Dutch research group on pancreatic cancer surveillance in high-risk individuals. Factors associated with cancer worries in individuals participating in annual pancreatic cancer surveillance. Fam Cancer. 2017 Jan;16(1):143-151. doi: 10.1007/s10689-016-9930-4.

Reference Type RESULT
PMID: 27629874 (View on PubMed)

Harinck F, Nagtegaal T, Kluijt I, Aalfs C, Smets E, Poley JW, Wagner A, van Hooft J, Fockens P, Bruno M, Bleiker EM. Feasibility of a pancreatic cancer surveillance program from a psychological point of view. Genet Med. 2011 Dec;13(12):1015-24. doi: 10.1097/GIM.0b013e31822934f5.

Reference Type RESULT
PMID: 21857231 (View on PubMed)

Konings IC, Sidharta GN, Harinck F, Aalfs CM, Poley JW, Kieffer JM, Kuenen MA, Smets EM, Wagner A, van Hooft JE, van Rens A, Fockens P, Bruno MJ, Bleiker EM. Repeated participation in pancreatic cancer surveillance by high-risk individuals imposes low psychological burden. Psychooncology. 2016 Aug;25(8):971-8. doi: 10.1002/pon.4047. Epub 2015 Dec 3.

Reference Type RESULT
PMID: 26632416 (View on PubMed)

Cazacu IM, Luzuriaga Chavez AA, Saftoiu A, Bhutani MS. Psychological impact of pancreatic cancer screening by EUS or magnetic resonance imaging in high-risk individuals: A systematic review. Endosc Ultrasound. 2019 Jan-Feb;8(1):17-24. doi: 10.4103/eus.eus_25_18.

Reference Type RESULT
PMID: 30246710 (View on PubMed)

Paiella S, Capurso G, Cavestro GM, Butturini G, Pezzilli R, Salvia R, Signoretti M, Crippa S, Carrara S, Frigerio I, Bassi C, Falconi M, Iannicelli E, Giardino A, Mannucci A, Laghi A, Laghi L, Frulloni L, Zerbi A. Results of First-Round of Surveillance in Individuals at High-Risk of Pancreatic Cancer from the AISP (Italian Association for the Study of the Pancreas) Registry. Am J Gastroenterol. 2019 Apr;114(4):665-670. doi: 10.1038/s41395-018-0414-z.

Reference Type RESULT
PMID: 30538291 (View on PubMed)

Other Identifiers

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Psy-FPC

Identifier Type: -

Identifier Source: org_study_id

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