Effects of Pine Cone Extract on Serum IgE Levels in Perennial Rhinitis

NCT ID: NCT04024033

Last Updated: 2023-05-10

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 36 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2011-03-31
• Study Completion Date: 2023-10-31

Brief Summary

The medicinal properties of pinecones have been used for years to treat a variety of illnesses. In the mouse model, an extract of pine cones, poly-phenylpropanoid-polysaccharide complex (PPC), has been shown to reduce total serum IgE levels as well as decreased production of IL-4, a cytokine associated with allergic disease. In this study, the investigators aim to determine the effects that PPC will have on total serum IgE levels in adult subjects with perennial rhinitis.

Detailed Description

The study will be a parallel two-arm, double-blind design. The 80% power calculation was based upon preliminary data showing a greater than 30% reduction of total serum IgE in PPC recipients. This power calculation concluded that each arm will need a population of 18 subjects. These subjects will be recruited from a clinical practice of 4 academic allergists/immunologists. Seasonal allergy information will be recorded but the data will be analyzed for each group without any correction for seasonal effects.

Recruited subjects will sign the consent form, undergo a complete physical exam, and have skin testing repeated if historical skin tests data within three years is unavailable. The historical skin tests must have been performed using the same techniques as those used in the study. A prick skin test method using commercially available extracts will be used and the results graded according to standard criteria with measurements of the wheal and flare compared to the results of a positive control with histamine and a negative control of saline. A positive skin test will be defined as a wheal diameter 3 mm larger than the negative control with a flare of greater than or equal to 10 mm.

A nasal mucosal sample will also be obtained from the inferior turbinate with a plastic device (rhinoprobe). This sample will be frozen at the time of collection for future analysis. This procedure will be optional for subjects; if they consent it will be performed at each visit After screening, patients will be randomized to either of the two arms (placebo, or 32mg PPC/d). Patients will be instructed to take one capsule via oral route daily for 8 weeks. Subjects will be treated for two months with measurements of total serum IgE at the initial screening/randomization visit and following two months of treatment. Physical examination will be repeated at each visit. A variance of 5 days will be permitted for follow-up visits.

Rescue treatment with oral, non-sedating antihistamine will be permitted and number of doses will be recorded at each follow up visit. No nasal sprays will be allowed during the study. If symptoms are extreme, the study subject will be discontinued from the trial.

Conditions

Perennial Allergic Rhinitis

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: QUADRUPLE

Study Groups

capsule

patinets receiveing pine cone extract tablets

Group Type: ACTIVE_COMPARATOR

pine cone extract

Intervention Type: DIETARY_SUPPLEMENT

pine cone extract capsule

placebo capsule

patinets receiving placebo

Group Type: PLACEBO_COMPARATOR

placebo

Intervention Type: OTHER

placebo capsule

Interventions

pine cone extract

pine cone extract capsule

Intervention Type: DIETARY_SUPPLEMENT

placebo

placebo capsule

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

1. Subjects with perennial allergic rhinitis with or without seasonal allergic rhinitis

2. Male or female participants must be 18 years of age or older

Exclusion Criteria

1. Subjects receiving subcutaneous allergen immunotherapy or monoclonal anti-IgE (omalizumab)

2. Subject with hypersensitivity to PPC

3. Pregnant subjects (lactating post-partum women will be allowed to participate)

4. Subjects who are unable to cooperate/comply with study procedures or communicate with investigator in order to successfully complete the study

5. Subjects with severe skin disorders such as atopic dermatitis, dermatographism, psoriasis who could not have allergy skin testing and who have no prior skin testing completed within 3 years

6. Subjects with an infirmity, disability, or geographical location which seems likely to prevent regular attendance for patient visits

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University of South Florida

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Dennis Ledford, M.D.

Role: PRINCIPAL_INVESTIGATOR

Division of Allergy and Immunology, USF

Locations

Usf Asthma Allergy and Immunology Cru

Tampa, Florida, United States

Countries

United States

Other Identifiers

Pine Cone Extract

Identifier Type: -

Identifier Source: org_study_id