Safety of PATANASE Nasal Spray in Patients With Perennial Allergic Rhinitis

NCT ID: NCT00789555

Last Updated: 2018-02-08

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

1260 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-11-30

Study Completion Date

2011-01-31

Brief Summary

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The purpose of this study was to assess local nasal adverse effects, as well as systemic effects, of PATANASE nasal spray when compared with Patanase Vehicle, pH 3.7 and Patanase Vehicle, pH 7.0 in patients with perennial allergic rhinitis (PAR).

Detailed Description

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Conditions

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Perennial Allergic Rhinitis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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PATANASE

Olopatadine hydrochloride 0.6% nasal spray (PATANASE), two sprays in each nostril twice a day (morning and evening) for up to 12 months

Group Type EXPERIMENTAL

Olopatadine hydrochloride 0.6% nasal spray (PATANASE)

Intervention Type DRUG

Two sprays in each nostril twice a day (morning and evening) for up to 12 months

Patanase Vehicle, pH 3.7

Olopatadine nasal spray vehicle, pH 3.7, two sprays in each nostril twice a day (morning and evening) for up to 12 months

Group Type PLACEBO_COMPARATOR

Olopatadine nasal spray vehicle, pH 3.7

Intervention Type OTHER

Two sprays in each nostril twice a day (morning and evening) for up to 12 months

Patanase Vehicle, pH 7.0

Olopatadine nasal spray vehicle, pH 7.0, two sprays in each nostril twice a day (morning and evening) for up to 12 months

Group Type PLACEBO_COMPARATOR

Olopatadine nasal spray vehicle, pH 7.0

Intervention Type OTHER

Two sprays in each nostril twice a day (morning and evening) for up to 12 months

Interventions

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Olopatadine hydrochloride 0.6% nasal spray (PATANASE)

Two sprays in each nostril twice a day (morning and evening) for up to 12 months

Intervention Type DRUG

Olopatadine nasal spray vehicle, pH 3.7

Two sprays in each nostril twice a day (morning and evening) for up to 12 months

Intervention Type OTHER

Olopatadine nasal spray vehicle, pH 7.0

Two sprays in each nostril twice a day (morning and evening) for up to 12 months

Intervention Type OTHER

Other Intervention Names

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PATANASE®

Eligibility Criteria

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Inclusion Criteria

1. Sign informed consent;
2. Normal nasal exam;
3. History of perennial allergic rhinitis;
4. Allergy to perennial allergen documented by allergy testing;
5. Age 12 years and older;
6. Must follow instructions;
7. Must make required study visits;
8. Negative pregnancy test and adequate birth control methods for females of childbearing potential;
9. Refrain from certain allergy medications during the study;

Exclusion Criteria

1. Nasal disorders;
2. Use of substances that affect the nasal septum;
3. Exposure to industrial metal plating solutions;
4. Uncontrolled, severe, or unstable diseases;
5. Hypersensitivity to the study drug or nasal spray components;
6. Relative of site staff with access to the protocol;
7. Participation in another investigational study within 30 days or at the same time as this study;
8. Medical Monitor decision;
Minimum Eligible Age

12 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Alcon Research

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Contact Alcon Call Center For Trial Locations

Fort Worth, Texas, United States

Site Status

Countries

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United States

Other Identifiers

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C-08-32

Identifier Type: -

Identifier Source: org_study_id

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