Bone Healing at Non-submerged Implants Installed With Different Insertion Torques.

NCT ID: NCT04017156

Last Updated: 2019-07-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-07-20

Study Completion Date

2017-10-17

Brief Summary

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The objective of the study is to evaluate histomorphometrically the healing at implants installed with standard or very low insertion torque values.

Detailed Description

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Very high insertion torque values have been recommended when immediate loading is applied to implants.1 However, it has been shown that similar clinical outcomes may be achieved even with insertion torque values ≤15 Ncm when implants are splinted together. Due to the contradictory outcomes on the influence of the torque on osseointegration and a lack of histological data in humans, there is a need of more evidences that may support the clinicians in the decision making when an unintentional low insertion torque occur at implants during the daily practice. So the aim of the study i evaluate histomorphometrically the healing at implants installed in Twelve volunteer patients that will be recruited. Two screw-shaped titanium devices will be installed in the distal segments of the mandible using insertion torque values of either \<10 Ncm or \~30 Ncm. The implants were left to heal in a non-submerged fashion. After 8 weeks, biopsies will be retrieved and ground sections will be prepared for histological evaluation.

Conditions

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Edentulous; Alveolar Process, Atrophy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Clinical Trial
Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors
The two recipient sites will be selected prior the surgery, while the type of site preparation will be randomly decided. The randomization will be performed electronically (randomization.com) by a researcher neither involved in the selection of the patients nor in installation of the devices (DB). Sealed opaque envelopes will be prepared and opened at the time of surgery by an author not involved in the surgery (DB). Surgeon and patients will be blinded.

Study Groups

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Test site (torque of <10 Ncm)

The test sites (\<10 Ncm) will be over-prepared with drills of larger diameter

Group Type EXPERIMENTAL

implant installation

Intervention Type PROCEDURE

All site preparations will be performed deeper compared to the length of the implant so that the implant apex cannot reach the bottom of the osteotomy.

Control site (torque of ~30 Ncm)

the standard sites (\~30 Ncm)will be prepared with the corresponding drills suggested by the manufacturer

Group Type OTHER

implant installation

Intervention Type PROCEDURE

All site preparations will be performed deeper compared to the length of the implant so that the implant apex cannot reach the bottom of the osteotomy.

Interventions

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implant installation

All site preparations will be performed deeper compared to the length of the implant so that the implant apex cannot reach the bottom of the osteotomy.

Intervention Type PROCEDURE

Other Intervention Names

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implant surgery

Eligibility Criteria

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Inclusion Criteria

* presence of at least two edentulous zone in the posterior segment of the mandible
* ≥ 25 years of age
* smoking ≤ 10 cigarettes per day
* Good general health
* No contraindication for oral surgical procedures.
* Not being pregnant.

Exclusion Criteria

* Presence of systemic disorders
* Chemotherapy or radiotherapy;
* Smokers \>10 cigarettes per day
* Previous bone augmentation procedures in the region
Minimum Eligible Age

25 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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ARDEC Academy

NETWORK

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Colombia

Cartagena, Cartagena, Colombia

Site Status

Countries

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Colombia

References

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Trisi P, Todisco M, Consolo U, Travaglini D. High versus low implant insertion torque: a histologic, histomorphometric, and biomechanical study in the sheep mandible. Int J Oral Maxillofac Implants. 2011 Jul-Aug;26(4):837-49.

Reference Type RESULT
PMID: 21841994 (View on PubMed)

Cesaretti G, Botticelli D, Renzi A, Rossi M, Rossi R, Lang NP. Radiographic evaluation of immediately loaded implants supporting 2-3 units fixed bridges in the posterior maxilla: a 3-year follow-up prospective randomized controlled multicenter clinical study. Clin Oral Implants Res. 2016 Apr;27(4):399-405. doi: 10.1111/clr.12565. Epub 2015 Feb 9.

Reference Type RESULT
PMID: 25664701 (View on PubMed)

Gallucci GO, Benic GI, Eckert SE, Papaspyridakos P, Schimmel M, Schrott A, Weber HP. Consensus statements and clinical recommendations for implant loading protocols. Int J Oral Maxillofac Implants. 2014;29 Suppl:287-90. doi: 10.11607/jomi.2013.g4. No abstract available.

Reference Type RESULT
PMID: 24660204 (View on PubMed)

Pantani F, Botticelli D, Garcia IR Jr, Salata LA, Borges GJ, Lang NP. Influence of lateral pressure to the implant bed on osseointegration: an experimental study in dogs. Clin Oral Implants Res. 2010 Nov;21(11):1264-70. doi: 10.1111/j.1600-0501.2010.01941.x.

Reference Type RESULT
PMID: 20626423 (View on PubMed)

Rea M, Lang NP, Ricci S, Mintrone F, Gonzalez Gonzalez G, Botticelli D. Healing of implants installed in over- or under-prepared sites--an experimental study in dogs. Clin Oral Implants Res. 2015 Apr;26(4):442-446. doi: 10.1111/clr.12390. Epub 2014 Mar 31.

Reference Type RESULT
PMID: 24684411 (View on PubMed)

Rea M, Botticelli D, Ricci S, Soldini C, Gonzalez GG, Lang NP. Influence of immediate loading on healing of implants installed with different insertion torques--an experimental study in dogs. Clin Oral Implants Res. 2015;26(1):90-5. doi: 10.1111/clr.12305. Epub 2013 Dec 9.

Reference Type RESULT
PMID: 24313303 (View on PubMed)

Barone A, Alfonsi F, Derchi G, Tonelli P, Toti P, Marchionni S, Covani U. The Effect of Insertion Torque on the Clinical Outcome of Single Implants: A Randomized Clinical Trial. Clin Implant Dent Relat Res. 2016 Jun;18(3):588-600. doi: 10.1111/cid.12337. Epub 2015 Jun 5.

Reference Type RESULT
PMID: 26043651 (View on PubMed)

Verardi S, Swoboda J, Rebaudi F, Rebaudi A. Osteointegration of Tissue-Level Implants With Very Low Insertion Torque in Soft Bone: A Clinical Study on SLA Surface Treatment. Implant Dent. 2018 Feb;27(1):5-9. doi: 10.1097/ID.0000000000000714.

Reference Type RESULT
PMID: 29271785 (View on PubMed)

Verrastro Neto A, Andrade R, Correa MG, Casarin RCV, Casati MZ, Pimentel SP, Ribeiro FV, Cirano FR. The impact of different torques for the insertion of immediately loaded implants on the peri-implant levels of angiogenesis- and bone-related markers. Int J Oral Maxillofac Surg. 2018 May;47(5):651-657. doi: 10.1016/j.ijom.2017.11.001. Epub 2017 Nov 23.

Reference Type RESULT
PMID: 29173997 (View on PubMed)

Duyck J, Corpas L, Vermeiren S, Ogawa T, Quirynen M, Vandamme K, Jacobs R, Naert I. Histological, histomorphometrical, and radiological evaluation of an experimental implant design with a high insertion torque. Clin Oral Implants Res. 2010 Aug;21(8):877-84. doi: 10.1111/j.1600-0501.2010.01895.x. Epub 2010 Apr 30.

Reference Type RESULT
PMID: 20528892 (View on PubMed)

Duyck J, Roesems R, Cardoso MV, Ogawa T, De Villa Camargos G, Vandamme K. Effect of insertion torque on titanium implant osseointegration: an animal experimental study. Clin Oral Implants Res. 2015 Feb;26(2):191-6. doi: 10.1111/clr.12316. Epub 2013 Dec 11.

Reference Type RESULT
PMID: 24325598 (View on PubMed)

Muktadar AK, Gangaiah M, Chrcanovic BR, Chowdhary R. Evaluation of the effect of self-cutting and nonself-cutting thread designed implant with different thread depth on variable insertion torques: An histomorphometric analysis in rabbits. Clin Implant Dent Relat Res. 2018 Aug;20(4):507-514. doi: 10.1111/cid.12611. Epub 2018 Apr 16.

Reference Type RESULT
PMID: 29659124 (View on PubMed)

Berardini M, Trisi P, Sinjari B, Rutjes AW, Caputi S. The Effects of High Insertion Torque Versus Low Insertion Torque on Marginal Bone Resorption and Implant Failure Rates: A Systematic Review With Meta-Analyses. Implant Dent. 2016 Aug;25(4):532-40. doi: 10.1097/ID.0000000000000422.

Reference Type RESULT
PMID: 27129002 (View on PubMed)

Balshi SF, Wolfinger GJ, Balshi TJ. A retrospective analysis of 44 implants with no rotational primary stability used for fixed prosthesis anchorage. Int J Oral Maxillofac Implants. 2007 May-Jun;22(3):467-71.

Reference Type RESULT
PMID: 17622014 (View on PubMed)

Rodrigo D, Aracil L, Martin C, Sanz M. Diagnosis of implant stability and its impact on implant survival: a prospective case series study. Clin Oral Implants Res. 2010 Mar;21(3):255-61. doi: 10.1111/j.1600-0501.2009.01820.x. Epub 2009 Dec 4.

Reference Type RESULT
PMID: 19958375 (View on PubMed)

Caneva M, Lang NP, Calvo Guirado JL, Spriano S, Iezzi G, Botticelli D. Bone healing at bicortically installed implants with different surface configurations. An experimental study in rabbits. Clin Oral Implants Res. 2015 Mar;26(3):293-9. doi: 10.1111/clr.12475. Epub 2014 Sep 15.

Reference Type RESULT
PMID: 25220835 (View on PubMed)

Ferri M, Lang NP, Angarita Alfonso EE, Bedoya Quintero ID, Burgos EM, Botticelli D. Use of sonic instruments for implant biopsy retrieval. Clin Oral Implants Res. 2015 Nov;26(11):1237-43. doi: 10.1111/clr.12466. Epub 2014 Aug 11.

Reference Type RESULT
PMID: 25109369 (View on PubMed)

Amari Y, Piattelli A, Apaza Alccayhuaman KA, Mesa NF, Ferri M, Iezzi G, Botticelli D. Bone healing at non-submerged implants installed with different insertion torques: a split-mouth histomorphometric randomized controlled trial. Int J Implant Dent. 2019 Dec 5;5(1):39. doi: 10.1186/s40729-019-0194-2.

Reference Type DERIVED
PMID: 31802302 (View on PubMed)

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

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protocol #04-2014

Identifier Type: -

Identifier Source: org_study_id

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