Viral and Microbial Circulation Between Humans, Domesticated and Wild Animals Along an Ecotone, Democratic Republic of Congo

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-03-15

Study Completion Date

2021-09-21

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study will evaluate the overlap between the intestinal microbiome and virome of wild and domesticated animals and human beings living in close proximity in three sites along an ecotone (ecological gradient) in the Democratic Republic of Congo.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Study of the Interactions Between Dientamoba Fragilis and the Gut Microbiota

NCT02534272

Diarrhea

TERMINATED

Prevalence of Faecal Bacteriophage in Patients With Digestive Symptoms

NCT06524791

Gastroenteritis

NOT_YET_RECRUITING

Multi-Drug Resistant Bacteria Carriage After Travel

NCT03477760

Beta Lactam Resistant Bacterial Infection (Disorder)

COMPLETED

Stool Collection for Model

NCT06988514

A03 - Digestive System 03 - Bacteria

COMPLETED NA

Sampling of Human Microbiota in Order to Test, on a Mouse Model, Individualized Intervention Strategies During Aging

NCT04753580

Healthy Volunteers Frail Volunteers

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The MICROTONE study sheds light on zoonotic disease emergence by examining social and ecological pathways facilitating microbial and viral flows between people and selected wild and domesticated animals along a gradient of ecological change in a forest-savanna mosaic in the Democratic Republic of Congo, an epicenter of zoonotic disease emergence. The investigators analyze potential viral and bacterial overlap among humans and animals and explain this overlap (or not) through social sciences and ecological analyses of human and animal mobilities, practices and contacts. This multi-disciplinary, multi-species investigation in an ecotone (a transitional ecological zone linked to zoonotic disease emergence) offers a "pre-history" of spillover and emergence, tracing an ecological zeb of virome and microbial sharing among humans and animals. It will elucidate why such microbial and viral flows occur.

To conduct this investigation,there are two human sub-studies: the social sciences participatory study; and the clinical study. The clinical study will involve 30 human subjects from whom blood and stool samples will be collected. The social sciences participatory study will involve self-collected activity and animal contact data and oral interviews among 60 human subjects.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Zoonotic Disease

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NA

Intervention Model

SINGLE_GROUP

2 types of participants. Human subjects participating in microbiological and anthropological study. Human subjects participating in historical and anthropological study, providing a larger context for those from whom we will collect biological samples and anthropological data

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Microbiological, anthropological and historical study

30 adult participants will be recruited to self-report daily activities and contacts with domesticated and wild animals for a five month period. Following the five months of data collection, we will collect 5ml blood and 2g stool from each participant.

From the fifth month of investigation, an additional 30 adult participants will participate in oral anthropological, historical interviews to develop the socio-historical context of their changing activities and relations with selected domesticated and wild animals. No other intervention will be performed.

Group Type EXPERIMENTAL

blood sampling

Intervention Type BIOLOGICAL

5ml blood sampling

stool collection

Intervention Type BIOLOGICAL

self stool collection (2g)

Participatory activity and contact investigation

Intervention Type OTHER

30 human subjects will self-report daily activities and contacts with selected wild and domesticated animals for five months.

Anthropological and historical interviews

Intervention Type OTHER

Oral interviews on current and past practices and engagements with wild and domesticated animals will be conducted with the 30 human subjects who are recruited to self-report their activities (Participatory activity and contact investigation) and to provide blood and stool samples. Another 30 human subjects will be recruited only to participate in the same type of interviews, addressing past and present activities and relations with wild and domesticated animals.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

blood sampling

5ml blood sampling

Intervention Type BIOLOGICAL

stool collection

self stool collection (2g)

Intervention Type BIOLOGICAL

Participatory activity and contact investigation

30 human subjects will self-report daily activities and contacts with selected wild and domesticated animals for five months.

Intervention Type OTHER

Anthropological and historical interviews

Oral interviews on current and past practices and engagements with wild and domesticated animals will be conducted with the 30 human subjects who are recruited to self-report their activities (Participatory activity and contact investigation) and to provide blood and stool samples. Another 30 human subjects will be recruited only to participate in the same type of interviews, addressing past and present activities and relations with wild and domesticated animals.

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Age 18 years or older
* Accept participation in study
* Residing in one of three villages selected
* In good health and able to conduct habitual daily activities
* Accept self-collection of 2g of stool
* Accept blood collection (2-2.5 ml) by a medical professional
* Accept to self-collect daily activities and contacts with selected wild and domesticated animals for five months
* Accept to participate in an anthropological-historical interview on changing practices and contacts with wild and domesticated animals

Exclusion Criteria

* Vulnerable adults will not be included
* Women who are pregnant or nursing at the time of recruitment and inclusion will not be included.
* Adults declaring themselves ill and unable to conduct their habitual daily activities will not be included.
* Adults with a chronic illness will not be included
* Adults who have a family member already included in the study will not be included.
* Adults refusing either recording of interviews or note-taking during interviews will not be included.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes