Inflammatory Response After One-lung Ventilation According to Ventilation Methods
NCT ID: NCT04007354
Last Updated: 2019-07-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
40 participants
INTERVENTIONAL
2018-06-25
2019-05-20
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Intubated
The patient was intubated with a left-sided double-lumen endobronchial tube. The protective ventilation was performed as follows: a tidal volume of 6 mL/kg predicted body weight, I:E ratio of 1:2, a respiratory rate to maintain PaCO2 within 35 to 45 mmHg, and positive end-expiratory pressure at 5 cmH2O. If the airway pressure exceeded 25 cmH2O, tidal volume was adjusted.
No interventions assigned to this group
Non-intubated
The patients were oxygenated via facial mask with O2 5\~10 L/min during the whole procedure. The end-tidal carbon dioxide (EtCO2) was measured by insertion of a detector inside one of the nostrils. Respiration rate was maintained between 12 and 20 breaths/min with adjustment of anesthetics.
Ventilation method
Depending on the group assignment, mechanical ventilation or spontaneous breathing was performed.
Interventions
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Ventilation method
Depending on the group assignment, mechanical ventilation or spontaneous breathing was performed.
Eligibility Criteria
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Inclusion Criteria
* 20 \< age \< 75
* American Society of Anesthesiologists (ASA) classification I\~II
Exclusion Criteria
* steroid administration within 1 month
* hematologic / autoimmune disease
* congestive heart failure (NYHA class III\~IV) or significant arrhythmia
* severe obstructive / restrictive pulmonary disease
* previous history of thoracic surgery
* BMI \>28kg/m2
* expected difficult airway
20 Years
75 Years
ALL
No
Sponsors
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The Catholic University of Korea
OTHER
Seoul St. Mary's Hospital
OTHER
Responsible Party
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Wonjung Hwang
Assistant professor
Locations
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Seoul St.Mary's Hospital
Seoul, , South Korea
Countries
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References
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Jeon J, Sung S, Moon Y, Koo J, Hyun K, Han K, Hwang W. Comparison of early postoperative cytokine changes in patients undergoing intubated and non-intubated thoracic surgery: a randomized controlled trial. Interact Cardiovasc Thorac Surg. 2021 Apr 8;32(3):343-350. doi: 10.1093/icvts/ivaa265.
Other Identifiers
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KC17EESI0558
Identifier Type: -
Identifier Source: org_study_id
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