Impact of Clinical Pharmacist Interventions in Vitamin K Antagonists Management at One Teaching Hospital in Vietnam

NCT ID: NCT03996629

Last Updated: 2019-06-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

800 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-08-01

Study Completion Date

2022-12-31

Brief Summary

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For decades, vitamin K antagonists are the main oral anticoagulants used for primary and secondary prevention of arterial and venous thromboembolic events. Both observational and randomized controlled trials have confirmed an outstanding outcome (the percentage of time in the therapeutic range-TTR, effectiveness and safety) in patients received anticoagulation management provided by pharmacists (AMPP) in comparing with usual physician care.

However, at present, pharmacist-managed anticoagulation services are still not popular in developing countries. In addition, there are few studies evaluating the patient outcomes with the AMPP model in Vietnam. Above all, it is important to explore whether AMPP is superior to other usual models in the improvement of effectiveness and safety.

Detailed Description

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The study is a randomized controlled trial. Patients who will use VKA are prospectively divided into routine group and pharmacist intervention group.

For the intervention group, patients receive an intensive medical education from pharmacists in anticoagulation management service. Pharmacists regularly provide telephone and outpatient follow-up. At the end of the 12-month follow-up, the percentage of TTR and major bleeding events will be evaluated in both groups.

Clinical data is designed to be collected from 800 patients, 400 patients in each group. Data will be analyzed by SPSS 20.0 software. P \< 0.05 is considered significant.

Conditions

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Anticoagulation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Pharmacist-managed anticoagulation service

Group Type EXPERIMENTAL

Patient education and compliance

Intervention Type OTHER

When the patient is enrolled in the intervention group, pharmacists provide medical education about the pathophysiology, medications, lifestyle, how to prevent, recognize and take care of bleeding events, etc. Establish a medical record for every follow-up examination and remind follow-ups by message, phone every month.

Usual medical care

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Patient education and compliance

When the patient is enrolled in the intervention group, pharmacists provide medical education about the pathophysiology, medications, lifestyle, how to prevent, recognize and take care of bleeding events, etc. Establish a medical record for every follow-up examination and remind follow-ups by message, phone every month.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients received a discharge prescription with VKA therapy from November 2018
* Patients agree to participate in the study
* Age 18 and older
* Duration of VKA therapy ≥12 months

Exclusion Criteria

* Patients with cognitive impairment as diagnosed by physician
* Geographical and financial conditions do not allow patients to guarantee follow-up examination on schedule
* Patient has less than 3 INR test results after the first day participating in the study
* Cannot contact patient by phone call or face-to-face communication after the first day participating in the study
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Medicine and Pharmacy at Ho Chi Minh City

OTHER

Sponsor Role lead

Responsible Party

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Tien Hoang Tran

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Trang Dang, PhD

Role: STUDY_CHAIR

University Medical Center Ho Chi Minh City

Locations

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University Medical Center Ho Chi Minh City

Ho Chi Minh City, , Vietnam

Site Status

Countries

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Vietnam

Central Contacts

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Tien Hoang Tran, BSPharm

Role: CONTACT

84 364 969 137

Facility Contacts

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Tien Hoang Tran, BSPharm

Role: primary

84 364 969 137

Trang Dang, PhD

Role: backup

84 909 907 976

Other Identifiers

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UMCAM01

Identifier Type: -

Identifier Source: org_study_id

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