Clinical and Biological Database in Colon Cancer and Colic Tumors

NCT ID: NCT03976960

Last Updated: 2025-02-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

600 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-09-19

Study Completion Date

2030-12-31

Brief Summary

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Developement of a clinical and biological database in colon cancer and colic tumors in order to better understand tumor invasion and metastatic scattering processes. The investigators hope that a better understanding of tumoral invasion process will lead to the discovery of new biomarkers and new drugs.

Detailed Description

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As the second leading cause of cancer-related death in France, colorectal cancer is a major public health problem. Each year, 37 000 cases are newly diagnosed in France and 17 000 patients die of the disease.

Colorectal cancer is due to molecular and genetic damages involved in all tumorigenesis steps, transition from healthy tissue to adenoma and finally to invasive carcinoma stage. The investigators hope that a to better understand tumor invasion and metastatic scattering processes will allow therapeutic innovation and the emergence of new biomarkers.

However, the study of early tumorigenesis phases as well as advanced stages of the disease is currently limited due to a lack of tissue samples.

In this context, the Montpellier Cancer Institute (ICM) decided to initiate a biological collection dedicated to the tissular and blood samples of patients with colorectal cancer.

Conditions

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Cancer Colon

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Biological collection

For all the patients include in the study :

samples of blood samples collected before or after surgery but also samples in paraffin-embedded tissue sections.

In parallel to this biological collection, standardized clinical data will be entered into a database

Group Type EXPERIMENTAL

Biological collection

Intervention Type OTHER

The biological collection will also include samples of blood samples collected before or after surgery but also samples frozen and/or paraffin-embedded tissue sections.

Interventions

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Biological collection

The biological collection will also include samples of blood samples collected before or after surgery but also samples frozen and/or paraffin-embedded tissue sections.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Patient undergoing colon cancer surgery (stage I, II, III and IV)
2. Patient operated for liver or lung or peritoneal carcinomatosis metastases originating from colon cancer
3. Patient operated for pre-neoplastic lesion (adenomatous polyp /villous adenoma polyp),
4. Patient with familial polyposis eligible for colectomy
5. Age \> 18 years
6. Signed informed consent

Exclusion Criteria

1. Patient not affiliated to Social Protection system
2. Patient unable to understand or comply with study instructions or requirements for psychological, family, social or geographical reasons
3. Patient under guardianship
4. Minor patient
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Institut du Cancer de Montpellier - Val d'Aurelle

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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ERIC ASSENAT, M.D

Role: STUDY_CHAIR

Institut régional du cancer de Montpellier

Locations

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CHRU de Montpellier

Montpellier, Hérault, France

Site Status RECRUITING

Institut Régional du cancer de Montpellier

Montpellier, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Aurore MOUSSION

Role: CONTACT

4 67 61 31 02 ext. + 33

Facility Contacts

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Eric Assénat, MD

Role: primary

467330137 ext. +33

ERIC ASSENAT, MD

Role: primary

Other Identifiers

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BCB2014/01

Identifier Type: -

Identifier Source: org_study_id

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