Assessing Medical Menstrual Regulation in the United States

NCT ID: NCT03972358

Last Updated: 2021-03-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE2

Total Enrollment

284 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-02-12

Study Completion Date

2021-12-31

Brief Summary

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This study will assess the acceptability and use of medical menstrual regulation among women in the United States.

Detailed Description

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Medical menstrual regulation (MMR) entails the use of uterine evacuation medications by women with late menses without confirming pregnancy status. Provision of MMR in the United States could expand reproductive choice and service options for women. This study will collect data on the acceptability, efficacy, safety and feasibility of MMR among women with missed menses of 1-21 days

Conditions

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Menstrual Regulation

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Medical menstrual regulation

Mifepristone 200 mg orally on day 1.

Misoprostol 800 mcg buccally on day 2 (24 hours after mifepristone).

Group Type EXPERIMENTAL

Mifepristone

Intervention Type DRUG

All participants will receive 200 mg mifepristone, to be taken orally on day 1.

Misoprostol

Intervention Type DRUG

All participants will receive 800 mcg misoprostol, to be taken buccally 24 hours after mifepristone (day 2)

Interventions

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Mifepristone

All participants will receive 200 mg mifepristone, to be taken orally on day 1.

Intervention Type DRUG

Misoprostol

All participants will receive 800 mcg misoprostol, to be taken buccally 24 hours after mifepristone (day 2)

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

1. Age 18-49 years
2. General good health
3. Does not want to be pregnant
4. Does not want to verify pregnancy status at the study site
5. History of regular monthly menstrual cycles
6. Missed menses of 1-21 days
7. Sexual activity in the past 2 months
8. Willing and able to sign consent forms
9. Willing to provide urine sample at enrollment
10. Willing to return for a follow-up visit

Exclusion Criteria

1. Known allergies or contraindications to mifepristone and/or misoprostol
2. Symptoms of or risk factors for ectopic pregnancy
3. Current use of an IUD, contraceptive implant or injectable
Minimum Eligible Age

18 Years

Maximum Eligible Age

49 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Gynuity Health Projects

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Wendy R Sheldon, PhD

Role: PRINCIPAL_INVESTIGATOR

Gynuity Health Projects

Locations

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Carafem Health Center

Skokie, Illinois, United States

Site Status NOT_YET_RECRUITING

Carafem Health Center

Chevy Chase, Maryland, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Wendy R Sheldon, PhD

Role: CONTACT

212-448-1230

Facility Contacts

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Melissa Grant

Role: primary

855-729-2272

Melissa Grant

Role: primary

855-729-2272

Other Identifiers

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8002

Identifier Type: -

Identifier Source: org_study_id

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