Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
200 participants
INTERVENTIONAL
2018-01-01
2023-12-31
Brief Summary
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Even though CBT is generally effective, around 50% of patients do not benefit sufficiently from this treatment. The current study aims at optimizing the treatment of anxiety disorders by identifying predictors of treatment response. Multiple (neuro-)psychological, biological, genetic and behavioral variables will be combined into a comprehensive prediction model of treatment outcome. Knowledge on predictors can then be used to improve therapy on an individual patient level.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Unified treatment protocol
This intervention group receives 16 sessions of CBT-based, individual psychotherapy using to the Unified Treatment Protocol for the treatment of emotional disorders by Barlow et al. (2011).
Unified Treatment Protocol
The Unified Treatment Protocol (UP) is a transdiagnostic psychotherapeutic treatment manual for emotional disorders, that is based on CBT principles and focuses on changing dysfunctional emotion regulation.
Waitlist Control Group
Participants in the waitlist control group gain access to the Unified Treatment after a waiting period of 16 weeks
No interventions assigned to this group
Interventions
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Unified Treatment Protocol
The Unified Treatment Protocol (UP) is a transdiagnostic psychotherapeutic treatment manual for emotional disorders, that is based on CBT principles and focuses on changing dysfunctional emotion regulation.
Eligibility Criteria
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Inclusion Criteria
* one of the following primary axis I disorders according to the Diagnostic and Statistical Manual of Mental Disorders (DSM): Panic Disorder with or without Agoraphobia; Social Anxiety Disorder; Anxiety Disorder not otherwise specified, Adjustment Disorder with Anxiety, Adjustment Disorder with Mixed Anxiety and Depression; Specific Phobia; Generalized Anxiety Disorder
* if on medication If on medication or in other types of treatments, patients must be willing to remain stable on their treatment for the duration of the acute phase/therapy of the study
* not currently receiving other psychotherapeutic treatment for anxiety or another condition
* fluent German
* provision of written informed consent
Exclusion Criteria
* medical relative contraindications involve conditions that impede thorough exposure, e.g. cardiovascular diseases, autoimmune diseases or pregnancy
* current or past schizophrenia, psychosis, or bipolar disorder
* current suicidal ideation.
* current substance/alcohol dependence or abuse
* cluster A or B personality disorder
* pregnancy (for women)
18 Years
65 Years
ALL
No
Sponsors
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Psychiatric University Hospital, Zurich
OTHER
Swiss National Science Foundation
OTHER
University of St.Gallen
OTHER
University of Zurich
OTHER
Responsible Party
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Principal Investigators
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Birgit Kleim, Prof. Dr.
Role: PRINCIPAL_INVESTIGATOR
University of Zurich
Locations
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University of Zurich
Zurich, , Switzerland
Countries
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Central Contacts
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Facility Contacts
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References
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Muller-Bardorff M, Schulz A, Paersch C, Recher D, Schlup B, Seifritz E, Kolassa IT, Kowatsch T, Fisher A, Galatzer-Levy I, Kleim B. Optimizing Outcomes in Psychotherapy for Anxiety Disorders Using Smartphone-Based and Passive Sensing Features: Protocol for a Randomized Controlled Trial. JMIR Res Protoc. 2024 May 14;13:e42547. doi: 10.2196/42547.
Other Identifiers
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10001C_169827
Identifier Type: -
Identifier Source: org_study_id
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