BiLirubin Decrease Under Phototherapy Exposure in the Preterm Newborn in Incubator

NCT ID: NCT03942757

Last Updated: 2020-03-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-05-02

Study Completion Date

2020-03-19

Brief Summary

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Phototherapy is routinely used in neonatal intensive care units for the treatment of jaundice. Guidelines focus mainly on bilirubin serum levels to start the phototherapy. Only few data are available about clinical management of phototherapy devices and subsequently the impact on bilirubin serum decrease. Especially there are no strong recommendations about phototherapy duration, irradiance measurements, incubator temperature and humidity settings. Various factors can influence irradiance and thus the preterm infant bilirubin serum decrease. This study aims at evaluating the impact of an educational program on the use and efficacy of phototherapy in a neonatal intensive care unit.

Detailed Description

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Only few data are available about clinical management of phototherapy devices for the treatment of jaundice in the preterm infant.

This study is a prospective, monocentric, observational study. Preterm infant \< 35 weeks of gestation with a jaundice requiring phototherapy according to NICE guidelines can be included for the duration of the phototherapy treatment.

The decrease in bilirubin serum level before and after phototherapy treatment will be measured.

This decrease in bilirubin serum level will be assessed for two consecutive periods before and after an educational program on jaundice management of the preterm infant.

The investigators aim at demonstrating that an educational program could improve phototherapy management and result in a higher decrease in bilirubin serum during treatment of the preterm infant with jaundice.

Conditions

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Preterm Infant Jaundice, Neonatal Phototherapy

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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observation before educational program

100 preterm infant medical records will be studied in a first part of this observational study

bilirubin serum level determination

Intervention Type OTHER

bilirubin serum level before and after phototherapy treatment will be measured

Phototherapy

Intervention Type OTHER

Preterm infant \< 35 weeks of gestation with a jaundice requiring phototherapy according to NICE guidelines can be included for the duration of the phototherapy treatment.

Observation after educational program

An educational program will be implemented in the unit after this first period. 100 preterm infant will be included in a second part of this observational study.

bilirubin serum level determination

Intervention Type OTHER

bilirubin serum level before and after phototherapy treatment will be measured

Phototherapy

Intervention Type OTHER

Preterm infant \< 35 weeks of gestation with a jaundice requiring phototherapy according to NICE guidelines can be included for the duration of the phototherapy treatment.

Interventions

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bilirubin serum level determination

bilirubin serum level before and after phototherapy treatment will be measured

Intervention Type OTHER

Phototherapy

Preterm infant \< 35 weeks of gestation with a jaundice requiring phototherapy according to NICE guidelines can be included for the duration of the phototherapy treatment.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* preterm infant less than 35 weeks gestation
* preterm infant hospitalized in the neonatal intensive care unit of CHU Amiens-Picardie
* preterm infant placed in an incubator
* preterm infant with a jaundice requiring treatment according to NICE guidelines
* preterm infant with a no hemolytic disease
* preterm infant with informed written consent from the parents

Exclusion Criteria

* preterm infant more than 35 weeks of gestation
* preterm infant with hemolytic disease
* preterm infant with Jaundice related to a cholestasis
* Jaundice requiring exchange transfusion
Maximum Eligible Age

1 Day

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Centre Hospitalier Universitaire, Amiens

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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CHU Amiens

Amiens, , France

Site Status

Countries

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France

Other Identifiers

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PI2018_843_0021

Identifier Type: -

Identifier Source: org_study_id

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