HIIT + RT on Body Composition and Gut Microbiota in Postmenopausal Women (PACWOMan)

NCT ID: NCT03940924

Last Updated: 2022-03-31

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 17 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2019-03-01
• Study Completion Date: 2020-12-01

Brief Summary

Postmenopausal women, as men, are more prone to central or android obesity than premenopausal women. Recently, some studies have shown that obesity is associated with gut microbiota dysbiosis and gut microbiota could be responsible of fat mass accumulation. Moreover, abdominal fat mass accumulation is associated with an increase of cardiovascular disease risks.

Recent studies suggest that physical activity may positively alter gut microbiota composition. Accumulating evidence suggests that high intensity interval training (HIIT) is an effective strategy for reducing body fat of overweight individuals, especially at the abdominal level. Resistance Training (RT) is associated with increased muscle mass and strength gain in main muscle groups. Thus, RT is also an interesting modality to fight against deconditioning and autonomy loss with age.

The aim of the study was to observed the effects of a 12-week high intensity interval training (HIIT) combined with resistance training (RT) program on gut microbiota and body composition changes in postmenopausal women.

It is hypothesized that HIIT +RT will improve gut microbiota and body composition (including whole body and (intra)-abdominal fat mass) in a concomitant and parallel way.

Detailed Description

The aim of the study was to observed the effects of a 12-week high intensity interval training (HIIT) combined with resistance training (RT) program on gut microbiota and body composition changes in postmenopausal women.

30 postmenopausal women will be randomly assigned to HIIT + RT (n= 15) group or Control group (n=15).

HIIT+RT: Each subject performed HIIT protocol consisted of repeated 60 cycles of speeding up for 8 s followed by pedalling slowly for 12 s (20min) Then they performed a single set of 10 exercises with 1 or 2min resting period between exercises. The set consisted of 8-12 repetitions at about 80% maximum repetition (1RM).

Control group : (no training program) Subjects will keep their life style.

Faecal microbiota and body composition will be measured before and after the intervention (3 months).

The investigators will examine the effects of HIIT + RT programs on:

Body composition : total-abdominal and visceral fat mass, total fat free mass and muscle mass Faecal concentration of short chain fatty acids Total fat free mass (and appendicular fat free mass) (DEXA) Glycemic profile (plasma HbA1c, plasma glucose, plasma insulin) Lipid profile (TG, HDL, LDL, total cholesterol) Aerobic capacity (VO2 max) Muscular capacity (fatigability, isometric and dynamic strenght)

Conditions

Overweight; Postmenopausal Women

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: PREVENTION
• Blinding Strategy: SINGLE

Study Groups

High Intensity Interval Training (HIIT) + Resistance Training

Subjects perform three sessions of training during 12 weeks. Session are composed of 20min HIIT program : 60 cycles of speeding up for 8s and pedaling slowly for 12s. (Intensity between 85 and 90% HRmax) + a single set circuits including 10 exercises with a load of 8-12 repetition at around 80% of maximal repetition (1RM)

Group Type: EXPERIMENTAL

Training program

Intervention Type: OTHER

High Intensity Interval Training + Resistance Training (HIIT + RT)

Control Group

Subjects don't have training program. They keep their life style.

Group Type: NO_INTERVENTION

No interventions assigned to this group

Interventions

Training program

High Intensity Interval Training + Resistance Training (HIIT + RT)

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Postmenopausal women
• BMI ≥ 25 and < 40
• Able to follow an exercise protocol
• Eating behavior and physical activity stable since at least 3 month

Exclusion Criteria

• Subject not able to perform exercise after medical examination
• Subject not able to perform bicycle exercise (pains)
• Use of β-blocker
• Medical treatment that could interfere with the different outcome measures (antibiotics)
• Hormonal Replacement Therapy (HRT)

• Minimum Eligible Age: 50 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: Yes

Sponsors

CREPS Auvergne Rhône-Alpes (AURA)

UNKNOWN

Sponsor Role: collaborator

Laboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Claire MOREL, Dr

Role: PRINCIPAL_INVESTIGATOR

CREPS Auvergne Rhône-Alpes / Vichy

Locations

CREPS Auvergne Rhône-Alpes / Vichy

Bellerive-sur-Allier, Allier, France

Countries

France

References

Dupuit M, Rance M, Morel C, Bouillon P, Boscaro A, Martin V, Vazeille E, Barnich N, Chassaing B, Boisseau N. Effect of Concurrent Training on Body Composition and Gut Microbiota in Postmenopausal Women with Overweight or Obesity. Med Sci Sports Exerc. 2022 Mar 1;54(3):517-529. doi: 10.1249/MSS.0000000000002809.

Reference Type: DERIVED

PMID: 34628447 (View on PubMed)

Other Identifiers

2018-A03230-55

Identifier Type: -

Identifier Source: org_study_id