CT-based Radiomic Signature Can Identify Adenocarcinoma Lung Tumor Histology

NCT ID: NCT03940846

Last Updated: 2020-04-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

650 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-03-01

Study Completion Date

2021-01-31

Brief Summary

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Lung cancer remains the leading cause of cancer related mortality worldwide, with more than 1.5 million related deaths annually. Lung cancer is divided into two main groups: Small Cell Lung Carcinoma (SCLC) and Non-Small Cell Lung Carcinoma (NSCLC), with prevalence of \~20% and 80% respectively. NSCLC is further subdivided into adenocarcinoma (the most common), squamous cell carcinoma (SCC), and large cell carcinoma. Furthermore, each subtype is likely to have specific mutations, which could be targeted for treatment.

Medical imaging and radiomics feature extraction represent a candidate alternative to conventional tissue biopsy, a theory that is investigated in this study.

Detailed Description

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Conditions

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Nonsmall Cell Lung Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Maastro (Lung1)

Open source dataset available at TCIA.org. The cohort includes CT scans of 422 patients diagnosed with NSCLC.

Virtual biopsy

Intervention Type DIAGNOSTIC_TEST

Radiomics -the high throughput extraction of quantitative features from medical imaging- extract features that might potentially decode biologic tumor information, which might ultimately reduce the need to use invasive procedure, such as tissue biopsy.

UCSF

A cohort of patients diagnosed with NSCLC at UCSF medical center. It includes CT scans of 165 patients.

Virtual biopsy

Intervention Type DIAGNOSTIC_TEST

Radiomics -the high throughput extraction of quantitative features from medical imaging- extract features that might potentially decode biologic tumor information, which might ultimately reduce the need to use invasive procedure, such as tissue biopsy.

Radboud

A cohort of patients diagnosed with NSCLC at Radboud medical center. It includes CT scans of 255 patients.

Virtual biopsy

Intervention Type DIAGNOSTIC_TEST

Radiomics -the high throughput extraction of quantitative features from medical imaging- extract features that might potentially decode biologic tumor information, which might ultimately reduce the need to use invasive procedure, such as tissue biopsy.

Stanford

Open source dataset available at TCIA.org. The cohort includes CT scans of 211 patients diagnosed with NSCLC.

Virtual biopsy

Intervention Type DIAGNOSTIC_TEST

Radiomics -the high throughput extraction of quantitative features from medical imaging- extract features that might potentially decode biologic tumor information, which might ultimately reduce the need to use invasive procedure, such as tissue biopsy.

Interventions

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Virtual biopsy

Radiomics -the high throughput extraction of quantitative features from medical imaging- extract features that might potentially decode biologic tumor information, which might ultimately reduce the need to use invasive procedure, such as tissue biopsy.

Intervention Type DIAGNOSTIC_TEST

Other Intervention Names

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Radiomics-based histology prediction

Eligibility Criteria

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Inclusion Criteria

* Availability of diagnostic non-contrast enhanced CT scan.
* Availability of histologic tumor analysis results

Exclusion Criteria

\-
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of California, San Francisco

OTHER

Sponsor Role collaborator

Radboud University Medical Center

OTHER

Sponsor Role collaborator

Maastricht University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Maastricht University

Maastricht, Limburg, Netherlands

Site Status

Countries

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Netherlands

Other Identifiers

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LHist

Identifier Type: -

Identifier Source: org_study_id

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