Dexmedetomidine Versus Dexamethasone With Levobupivacaine in Interscalene Block

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-07-03

Study Completion Date

2019-01-01

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The investigators compared between dexamethasone and dexmedetomidine when added to levobupivacaine in the quality and duration of ultrasound-guided interscalene block during shoulder arthroscopy.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Dexmedetomidine in Postoperative Analgesia

NCT05705128

Pain Management

ENROLLING_BY_INVITATION PHASE2/PHASE3

Dexmedetomidine Versus Dexamethasone as Adjuvants to Bupivacaine for Intermediate Cervical Plexus Block

NCT05793060

Analgesia

RECRUITING PHASE4

Extension of Analgesia by Combined Injection of Dexamethasone and Dexmedetomidine After Arthroscopic Shoulder Surgery

NCT04394481

Analgesia

COMPLETED PHASE4

Dexmedetomidine in IVRA

NCT05123170

Regional Anesthesia Morbidity

COMPLETED PHASE4

The Efficacy of Adding Dexmedetomidine Perineurally to Bupivacaine in Ultrasound Guided Fascia Iliaca Block Versus Intravenously Infused Dexmedetomidine on Hemodynamic Stability Intraoperatively and Postoperative Analgesia Following Hip Arthroscopy

NCT04917029

Anesthesia

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Sixty patients were enrolled and divided into three groups 20 each, Group C received 35ml levobupivacaine+2ml normal saline under ultrasound guided interscalene block. Group H received 35ml levobupivacaine+8mg dexamethasone under ultrasound guided interscalene block. Group D received 35ml levobupivacaine+100umg dexmedetomidine+1ml normal saline. The primary outcome was the postoperative pain which was assessed by Visual analog score(VAS), the secondary outcomes were the onset and duration of sensory and motor block, the total amount of analgesic requirement, and blood cortisol level.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Postoperative Analgesia Postoperative Complications

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

three groups 20 each, Group C received 35ml levobupivacaine+2ml normal saline under ultrasound guided interscalene block. Group H received 35ml levobupivacaine+8mg dexamethasone under ultrasound guided interscalene block. Group D received 35ml levobupivacaine+100umg dexmedetomidine+1ml normal saline.

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

both the patients and the observer were blind to the treatment groups

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Control group

received 35ml levobupivacaine+2ml normal saline under ultrasound guided interscalene block.

Group Type PLACEBO_COMPARATOR

Saline

Intervention Type DRUG

2 ml normal saline

Dexamethasone group

received 35ml levobupivacaine+8mg dexamethasone

Group Type ACTIVE_COMPARATOR

Dexamethasone Injection

Intervention Type DRUG

8 mg dexamethasone

Dexmeteomidine group

received 35ml levobupivacaine+100umg dexmedetomidine+1ml normal saline.

Group Type ACTIVE_COMPARATOR

Dexmedetomidine Hydrochloride

Intervention Type DRUG

100 microgram dexmedetomidine

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Saline

2 ml normal saline

Intervention Type DRUG

Dexamethasone Injection

8 mg dexamethasone

Intervention Type DRUG

Dexmedetomidine Hydrochloride

100 microgram dexmedetomidine

Intervention Type DRUG

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

normal saline dexamethsone dexmedetomidine

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Sixty healthy patients ASA I-II
* Aged 18-60 years
* Of both sexes
* Scheduled for shoulder arthroscopy using ultrasound interscalene block were enrolled.

Exclusion Criteria

* Patients with a history of any allergic reactions to levobupivacaine, dexamethasone or α2 agonists
* All patients with hypertension, cardiac, hepatic, renal or pulmonary diseases, - Patients who were under treatment by α2 agonist or antagonists
* Pregnant women
* Psychiatric patients
* Patients with a previous history or clinical evidence of central or peripheral neurological disease
* Coagulopathy or anticoagulant/antiaggregant therapy
* Contralateral phrenic nerve paresis
* Patients who have an infection at the site of the block.
* Every patient who had an anatomical or vascular abnormality in the upper extremity were excluded from this study.

Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes