Lipopolysaccharide Metabolism and Identification of Potential Biomarkers Predictive of Graft-versus-host Disease After Allogeneic Stem Cell Transplantation

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

95 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-09-06

Study Completion Date

2025-05-23

Brief Summary

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This study is designed to assess the hypothesis that the lipopolysaccharide (LPS) activity index can be quantified early after transplantation, as well as the the PhosphoLipid Transfer Protein (PLTP) activity and these both biological variables are independent variables for predicting the risk of severe Graft versus Host Disease (GVHD).

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Detailed Description

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Conditions

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Hematologic Diseases Stem Cell Transplantation

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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All patients

Group Type OTHER

Blood sample

Intervention Type OTHER

blood samples (4 times; 14ml per visit)

Interventions

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Blood sample

blood samples (4 times; 14ml per visit)

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Hematologic malignancy in complete remission
* Patients eligible for allogeneic hematopoietic cell transplantation from a related or unrelated donor and after myeloablative or non-myeloablative conditioning.
* Regular follow-up in the center

Exclusion Criteria

* Treatment with a statin in progress
* Umbilical cord blood transplantation
* Hemoglobin level less than or equal to 8g / dl
* Known chronic inflammatory bowel disease or gastroenteritis at the time of inclusion.
* Chronic enteropathy with Clostridium Difficile

Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No