The Role of the Upper Colliculus in the Idiopathic Blepharospasm

NCT ID: NCT03903341

Last Updated: 2022-09-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

13 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-11-20

Study Completion Date

2021-11-19

Brief Summary

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This pilot study aims at investigating the role of superior colliculus in patients with idiopathic blepharospasm (BSP) de novo, compared to healthy subjects.

Detailed Description

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The objective of the study is to investigate the function of the superior colliculus (SC) related to visual stimulation by means of fMRI (functional magnetic resonance imaging) in patients with idiopathic BSP compared to healthy subjects. The hypothesis is that SC function is impaired in BSP (role of biomarker of SC).

Conditions

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Blepharospasm, Benign Essential

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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idiopathic blepharospasm (BSP) de novo

bold signal in visual pathway

Group Type OTHER

fMRI

Intervention Type OTHER

bold signal in visual pathway

Healthy subjects

bold signal in visual pathway

Group Type OTHER

fMRI

Intervention Type OTHER

bold signal in visual pathway

Interventions

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fMRI

bold signal in visual pathway

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Non treated idiopathic blepharospasm
* Age: 30- 70 years

Exclusion Criteria

* Under the following treatments: Botulin toxin, anticholinergic, benzodiazepines, baclofen, beta- and alpha-blockers collyrium
* No MRI Contraindication
Minimum Eligible Age

30 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospital, Grenoble

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Sara Meoni, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

CHU Grenoble Alpes

Locations

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CHU Grenoble Alpes

Grenoble, , France

Site Status

Countries

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France

Other Identifiers

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38RC17.399

Identifier Type: -

Identifier Source: org_study_id

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