Improved Orthostatic Tolerance = Better Cognitive Function in Parkinson's Disease

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-05-31

Study Completion Date

2018-10-31

Brief Summary

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Study on orthostatic Hypotension in Parkinson's disease

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Detailed Description

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Orthostatic hypotension (OH) in Parkinson's disease (PD) may not only be related to dizziness or light headedness but to deficits in attention, visual, and verbal memory. Would a successful treatment of OH which includes physiotherapy significantly improve OH and these cognitive deficits? By means of a randomized cross-over trial, we want to measure and compare the effects of OH therapy on orthostatic tolerance, as well as on attention, visuo-spatial working memory, and verbal memory in patients with PD. If confirmed, therapy of orthostatic hypotension would provide a sound and simple approach to improve those cognitive deficits originating from orthostatic hypotension.

Conditions

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Hypotension, Orthostatic Parkinson Disease Autonomic Failure Cognitive Impairment

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

SINGLE

Investigators

Study Groups

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Short_Physiotherapy

one period of physiotherapy (8 weeks)

Group Type OTHER

Physiotherapy

Intervention Type OTHER

Ambulatory leg-muscle oriented physiotherapy (2 x 45 minutes per week for at least 8 weeks) at Aachen University Hospital. Daily protocol of leg muscle training, exercises, sufficient fluid intake of 2liter/day, pressure stockings.

Long_Physiotherapy

two periods of physiotherapy (à 8 weeks)

Group Type OTHER

Physiotherapy

Intervention Type OTHER

Ambulatory leg-muscle oriented physiotherapy (2 x 45 minutes per week for at least 8 weeks) at Aachen University Hospital. Daily protocol of leg muscle training, exercises, sufficient fluid intake of 2liter/day, pressure stockings.

Interventions

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Physiotherapy

Ambulatory leg-muscle oriented physiotherapy (2 x 45 minutes per week for at least 8 weeks) at Aachen University Hospital. Daily protocol of leg muscle training, exercises, sufficient fluid intake of 2liter/day, pressure stockings.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Parkinson's patients
* Diagnostis of OH
* able to perform an ambulatory physiotherapy at Aachen University Hospital.

Exclusion Criteria

* deep brain stimulation or Pacemaker
* severe psychiatric disease
* severe heart disease
* severe vascular encephalopathy
* dementia
* pregnant or lactating women
* extreme pain or immobility

Minimum Eligible Age

40 Years

Maximum Eligible Age

95 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No