Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Negative Symptoms of Schizophrenia

NCT ID: NCT03896945

Last Updated: 2024-05-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE2/PHASE3

Total Enrollment

136 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-02-15

Study Completion Date

2023-05-23

Brief Summary

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This study will be conducted to evaluate the efficacy, safety, and tolerability of AVP-786, as compared with placebo, for the treatment of negative symptoms of schizophrenia.

Detailed Description

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Conditions

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Schizophrenia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Placebo

Placebo capsules will be administered orally twice a day over a 15-week period.

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

oral capsules

AVP-786

AVP-786 capsules will be administered orally twice a day over a 15-week period.

Group Type EXPERIMENTAL

AVP-786

Intervention Type DRUG

oral capsules

Interventions

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Placebo

oral capsules

Intervention Type DRUG

AVP-786

oral capsules

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Participants who meet the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-V) diagnostic criteria for schizophrenia confirmed by the Mini International Neuropsychiatric Interview (M.I.N.I) Version 7.0.2
* Participants must have well-controlled positive symptoms and prominent negative symptoms as defined by Positive and Negative Syndrome Scale (PANSS) criteria.
* Participants currently receiving a second-generation atypical antipsychotic drug (SGA) are eligible if they are stable and adherent to their dosing schedule.
* Participants must have a reliable informant (e.g., case manager, social worker, family member). The informant should be able to spend an adequate amount of time with the participant to be able to address behaviors, activities, and symptoms.

Exclusion Criteria

* Participants with current major depressive disorder (MDD)
* Participants with pseudo-parkinsonism secondary to their ongoing antipsychotic medication
* Participants currently using anticholinergic medications
* Participants recently hospitalized as in-patients
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Otsuka Pharmaceutical Development & Commercialization, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Clinical Research Site

Little Rock, Arkansas, United States

Site Status

Clinical Research Site #840-041

Anaheim, California, United States

Site Status

Clinical Research Site #840-013

Bellflower, California, United States

Site Status

Clinical Research Site #840-079

Costa Mesa, California, United States

Site Status

Clinical Research Site #840-027

Culver City, California, United States

Site Status

Clinical Research Site #840-006

Garden Grove, California, United States

Site Status

Clinical Research Site #840-026

Glendale, California, United States

Site Status

Clinical Research Site# 840-067

La Habra, California, United States

Site Status

Clinical Research Site# 840-083

Lafayette, California, United States

Site Status

Clinical Research Site 840-002

Lemon Grove, California, United States

Site Status

Clinical Research Site

Oakland, California, United States

Site Status

Clinical Research Site #840-035

Oceanside, California, United States

Site Status

Clinical Research Site# 840-010

Panorama City, California, United States

Site Status

Clinical Research Site #840-012

Riverside, California, United States

Site Status

Clinical Research Site# 840-081

San Bernardino, California, United States

Site Status

Clinical Research Site #840-005

San Diego, California, United States

Site Status

Clinical Research Site #840-096

Santee, California, United States

Site Status

Clinical Research Site #840-015

Torrance, California, United States

Site Status

Clinical Research Site# 840-094

Doral, Florida, United States

Site Status

Clinical Research Site #840-046

Hollywood, Florida, United States

Site Status

Clinical Research Site Site #840-093

Homestead, Florida, United States

Site Status

Clinical Research Site #840-062

Lakeland, Florida, United States

Site Status

Clinical Research Site #840-024

Largo, Florida, United States

Site Status

Clinical Research Site #840-032

Miami, Florida, United States

Site Status

Clinical Research Site #840-080

Miami, Florida, United States

Site Status

Clinical Research Site #840-084

Miami Lakes, Florida, United States

Site Status

Clinical Research Site

Okeechobee, Florida, United States

Site Status

Clinical Research Site # 840-102

Weston, Florida, United States

Site Status

Clinical Research Site #840-088

Atlanta, Georgia, United States

Site Status

Clinical Research Site #840-091

Atlanta, Georgia, United States

Site Status

Clinical Research Site #840-008

Atlanta, Georgia, United States

Site Status

Clinical Research Site #840-063

Decatur, Georgia, United States

Site Status

Clinical Research Site

Chicago, Illinois, United States

Site Status

Clinical Research Site #840-090

Springfield, Illinois, United States

Site Status

Clinical Research Site

Lake Charles, Louisiana, United States

Site Status

Clinical Research Site #840-098

Shreveport, Louisiana, United States

Site Status

Clinical Research Site #840-072

Worcester, Massachusetts, United States

Site Status

Clinical Research Site #840-057

Flowood, Mississippi, United States

Site Status

Clinical Research Site #840-040

Olivette, Missouri, United States

Site Status

Clinical Research Site #840-029

Saint Charles, Missouri, United States

Site Status

Clinical Research Site #840-034

Saint Charles, Missouri, United States

Site Status

Clinical Research Site

St Louis, Missouri, United States

Site Status

Clinical Research Site #840-025

St Louis, Missouri, United States

Site Status

Clinical Research Site #840-028

Berlin, New Jersey, United States

Site Status

Clinical Research Site #840-009

Jamaica, New York, United States

Site Status

Clinical Research Site #840-070

New York, New York, United States

Site Status

Clinical Research Site

Rochester, New York, United States

Site Status

Clinical Research Site #840-074

Charlotte, North Carolina, United States

Site Status

Clinical Research Site #840-052

Middleburg Heights, Ohio, United States

Site Status

Clinical Research Site

Edmond, Oklahoma, United States

Site Status

Clinical Research Site #840-065

Oklahoma City, Oklahoma, United States

Site Status

Clinical Research Site #840-061

Media, Pennsylvania, United States

Site Status

Clinical Research Site

Norristown, Pennsylvania, United States

Site Status

Clinical Research Site #840-099

Myrtle Beach, South Carolina, United States

Site Status

Clinical Research Site

Memphis, Tennessee, United States

Site Status

Clinical Research Site

DeSoto, Texas, United States

Site Status

Clinical Research Site #840-058

Fort Worth, Texas, United States

Site Status

Clinical Research Site #840-018

Richardson, Texas, United States

Site Status

Clinical Research Site

San Antonio, Texas, United States

Site Status

Clinical Research Site #840-069

Springville, Utah, United States

Site Status

Clinical Research Site #840-051

Everett, Washington, United States

Site Status

Clinical Research Site #009

Kazanlak, , Bulgaria

Site Status

Clinical Research Site #100-008

Novi Iskar, , Bulgaria

Site Status

Clinical Research Site #100-007

Plovdiv, , Bulgaria

Site Status

Clinical Research Site #100-004 2

Sofia, , Bulgaria

Site Status

Clinical Research Site #100-006

Veliko Tarnovo, , Bulgaria

Site Status

Clinical Research Site #100-001

Vratsa, , Bulgaria

Site Status

Clinical Research Site

Tuszyn, Woj.Iodzkie, Poland

Site Status

Clinical Research Site #616-002

Bełchatów, , Poland

Site Status

Clinical Research Site #616-003

Pruszcz Gdański, , Poland

Site Status

Clinical Research Site #630-001

San Juan, , Puerto Rico

Site Status

Clinical Research Site # 630-002

San Juan, , Puerto Rico

Site Status

Countries

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United States Bulgaria Poland Puerto Rico

Other Identifiers

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2021-001352-33

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

18-AVP-786-207

Identifier Type: -

Identifier Source: org_study_id

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