Real World Study of Lapatinib Among Metastatic Breast Cancer Patients

NCT ID: NCT03894410

Last Updated: 2024-02-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

242 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-01-10

Study Completion Date

2020-05-20

Brief Summary

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A multicenter, retrospective, real world study of Lapatinib among Metastatic Breast Cancer (MBC) Patients in Clinical Practice.

Detailed Description

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This study collected patients used Lapatinib-base therapy among MBC, and tried to figure out if there was difference between single anti-Her2 treatment and dual anti-Her2 treatment. Furthermore, this study investigated the treatment after Lapatinib.

Conditions

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Breast Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Continuing Lapatinib

Patients continued using treatment containing Lapatinib after progression on Lapatinib.

No interventions assigned to this group

Change HER-2 treatment

Patients changed to another HER-2 targeted treatment after progression on Lapatinib (ado-trastuzumab emtansine, trastuzumab, etc.).

No interventions assigned to this group

Lapatinib plus capetabine

Patients used lapatinib plus capetabine.

No interventions assigned to this group

Lapatinib plus Trastuzumab and one chemotherapy

Patients used lapatinib plus trastuzumab and one chemo regimen.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Patients who were treated with Lapatinib between June 2014 to June 2018.
* Patients experienced progression on prior trastuzumab-containing regimens and a taxane.
* Complete medical history was available.

Exclusion Criteria

* Medical history was incomplete.
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Fudan University

OTHER

Sponsor Role lead

Responsible Party

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Biyun Wang, MD

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Biyun Wang, Professor

Role: PRINCIPAL_INVESTIGATOR

Fudan University

Locations

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Fudan University Shanghai Cancer Center

Shanghai, Shanghai Municipality, China

Site Status

Countries

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China

Other Identifiers

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YOUNGBC-6

Identifier Type: -

Identifier Source: org_study_id

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