Durability and Safety of EN3835 in the Treatment of EFP (Cellulite) in Women

NCT ID: NCT03893890

Last Updated: 2019-07-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

8 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-03-28

Study Completion Date

2019-06-25

Brief Summary

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This is a Phase 2b, rollover, long-term study to evaluate the safety and duration of efficacy of EN3835 in the treatment of women with EFP. Subjects who participated in and completed studies EN3835-201 and EN3835-202 and had composite improvement of at least 2 levels on both the CR-PCSS and PR-PCSS in study EN3835-201 will be eligible for this study.

Detailed Description

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Conditions

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Edematous Fibrosclerotic Panniculopathy

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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No Treatment

Subjects who participated in and completed studies EN3835-201 and EN3835-202 and had composite improvement of at least 2 levels on both the CR-PCSS and PR-PCSS in the EN3835-201 study, will be eligible for this study. The study will consist of up to two evaluations approximately 3 years after the first dose of study drug was received in the EN3835-201 study.

Previously Treated with EN3835

Intervention Type BIOLOGICAL

No treatment to be administered - Observational only

Interventions

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Previously Treated with EN3835

No treatment to be administered - Observational only

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* To qualify for the study a subject must:

1. Be able to provide voluntary written informed consent prior to the initiation of any study-specific procedures per the policy of the governing Institutional Review Board (IRB)/Independent Ethics Committee (IEC).
2. Have participated in and completed both studies EN3835-201 and EN3835-202 and had composite improvement of at least 2 levels on both the CR-PCSS and PR-PCSS in study EN3835-201.
3. Be willing and able to comply with all protocol required visits and assessments.

Exclusion Criteria

* Subjects will be ineligible for participation in this study if the subject:

1. Has had retreatment with EN3835 in the area initially treated during the EN3835-201 study since the completion of study EN3835-202.
2. Has had liposuction on the body region treated during the EN3835-201 study since the completion of that study.
3. Has had any of the following in the area initially treated during the EN3835-201 study since the completion of that study.

1. Injections (eg, mesotherapy); radiofrequency device treatments; laser treatment; or surgery (including subcision and/or powered subcision).
2. Any investigational treatment for EFP/cellulite.
3. Endermologie® or similar treatments.
4. Massage therapy.
5. Creams (eg, Celluvera™, TriLastin®).
4. Any other condition(s) that, in the Investigator's opinion, might indicate the subject is unsuitable for the study.
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Endo Pharmaceuticals

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Karen Chajko

Role: STUDY_DIRECTOR

Endo Pharmaceuticals

Locations

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Endo Clinical Trial Site #4

Clearwater, Florida, United States

Site Status

Endo Clinical Trial Site #1

Coral Gables, Florida, United States

Site Status

Endo Clinical Trial Site #5

Washington, Missouri, United States

Site Status

Endo Clinical Trial Site #2

New York, New York, United States

Site Status

Endo Clinical Trial Site #3

Charlottesville, Virginia, United States

Site Status

Countries

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United States

Other Identifiers

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EN3835-219

Identifier Type: -

Identifier Source: org_study_id

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