Post-marketing Surveillance (Use Result Surveillance) With Refixia®

NCT ID: NCT03875547

Last Updated: 2025-12-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ENROLLING_BY_INVITATION

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-08-23

Study Completion Date

2025-12-01

Brief Summary

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The participants are invited to take part in this study because they have Haemophilia B. The purpose of this study is to assess the safety and effectiveness of Refixia® about long-term routine use in patients with Haemophilia B. The participants will get Refixia® as prescribed to them by their study doctor. The study will last up to Sep 2025 for the participant. The participants may be asked to fill in the quality of life questionnaires (if they are above age of 15). The blood samples taken from the participants as part of routine clinical practice will also be used to investigate the safety for the long-term use of Refixia®.

Detailed Description

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Conditions

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Haemophilia B

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Patients with haemophilia B

Both patients who have not previously been exposed to Refixia® and patients previously exposed to Refixia® in one of the clinical trials can be included.

Refixia®

Intervention Type DRUG

Patients will be treated with commercially available Refixia® according to routine clinical practice at the discretion of the treating physician

Interventions

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Refixia®

Patients will be treated with commercially available Refixia® according to routine clinical practice at the discretion of the treating physician

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Signed consent obtained before any study-related activities (study-related activities are any procedure related to recording of data according to the protocol).
* The decision to initiate treatment with commercially available Refixia® has been made by the patient/Legally Acceptable Representative (LAR) and the treating physician before and independently from the decision to include the patient in this study. At each site of this study, all patients will be registered consecutively from the first patient after the launch of Refixia® (consecutively registered system).
* Diagnosis of haemophilia B in males or females, no age limitation. Patients younger than 12 years old will continue to be registered for 3 years of recruitment period regardless of the target number of patients.
* New patients who have not been previously exposed to Refixia®. Also patients previously exposed to Refixia® in NN7999-3639, -3747, -3774, -3775 or -3895 clinical trial can be enrolled in this study. The patients who have participated in NN7999 -3774 or -3895 clinical trial can be enrolled in this study as continuous cases until 30-September-2024 (one year before planned end of study date).

Exclusion Criteria

* Previous participation in this study. Participation is defined as having given informed consent in this study
* Mental incapacity, unwillingness or language barriers precluding adequate understanding or cooperation
* Known or suspected hypersensitivity to study product or related products.
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Novo Nordisk A/S

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Japan Red Cross Narita Hospital_Hematology and Oncology

Chiba, , Japan

Site Status

Chiba University Hospital_Diabetes, Metabolism and Endocrinology

Chiba-shi, Chiba, , Japan

Site Status

Hyogo prefectural kobe children's hospital

Hyōgo, , Japan

Site Status

Tokyo Medical University Ibaraki Medical Center_Ibaraki

Ibaraki, , Japan

Site Status

Ishikawa Prefectural Central Hospital

Ishikawa, , Japan

Site Status

St. Marianna University School of Medicine Hospital_Pediatrics

Kanagawa, , Japan

Site Status

Kitasato University Hospital

Kanagawa, , Japan

Site Status

Novo Nordisk Investigational Site

Søborg, , Denmark

Site Status

Nagoya University Hospital_Blood Transfusion

Aichi, , Japan

Site Status

Aomori Prefectural Central Hospital_Pediatrics

Aomori, , Japan

Site Status

Matsudo City General Hospital_Pediatrics

Chiba, , Japan

Site Status

Hospital of the University of Occupational And Environmental Health Japan, Pediatrics

Kitakyusyu-shi, Fukuoka, , Japan

Site Status

Gunma University Hospital, Dept. of Hematology

Maebashi-shi, Gunma, , Japan

Site Status

Naha City Hospital_Cardiovascular Medicine

Naha-shi, Okinawa, , Japan

Site Status

Nara Medical University Hospital_Pediatrics

Nara, , Japan

Site Status

The Hospital of Hyogo College of Medicine_Haematology

Nishinomiya-shi, Hyogo, , Japan

Site Status

Saitama Children's Med Centre_Hematology-Oncology

Saitama, , Japan

Site Status

Tokushima University Hospital_Pediatrics

Tokushima, , Japan

Site Status

Tokushima Red Cross Hospital_Pediatrics

Tokushima, , Japan

Site Status

Tokyo Medical Univ. Hospital_Laboratory Medicine

Tokyo, , Japan

Site Status

Ogikubo Hospital_Tokyo

Tokyo, , Japan

Site Status

Ishiyama Clinic

Yamagata, , Japan

Site Status

St. Marianna Univ., Yokohama City Seibu HP, Pediatrics Dept,

Yokohama-shi, Kanagawa, , Japan

Site Status

Countries

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Denmark Japan

Other Identifiers

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U1111-1198-6270

Identifier Type: OTHER

Identifier Source: secondary_id

NN7999-4404

Identifier Type: -

Identifier Source: org_study_id

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