Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
499 participants
INTERVENTIONAL
2019-06-05
2019-08-14
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
OTHER
SINGLE
Study Groups
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Informational Sheet
Persons picking up an opioid prescription will receive an informational sheet that describes how to properly dispose of leftover opioid medications
Informational Sheet
The informational sheet details how use opioid medicines safely, and lists ways to properly dispose of leftover opioids
Drug Disposal Kit
Persons picking up an opioid prescription will receive a drug disposal kit (DisposeRx Drug Disposal kit) and instructions on how to use it
Informational Sheet
The informational sheet details how use opioid medicines safely, and lists ways to properly dispose of leftover opioids
DisposeRx Drug Disposal kit
DisposeRx is a powder that is activated with water and traps leftover drugs (i.e. pills, capsules, caplets, liquids or tablets) in a semi-solid gel. The trapped drug cannot be retrieved from the resulting gel material for misuse, abuse or to leach into landfills. The participant can then throw away the biodegradable solid material in the prescription bottle into the trash, as it is safe for the environment.
No intervention
Persons picking up an opioid prescription will receive no additional information or materials on disposal.
No interventions assigned to this group
Interventions
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Informational Sheet
The informational sheet details how use opioid medicines safely, and lists ways to properly dispose of leftover opioids
DisposeRx Drug Disposal kit
DisposeRx is a powder that is activated with water and traps leftover drugs (i.e. pills, capsules, caplets, liquids or tablets) in a semi-solid gel. The trapped drug cannot be retrieved from the resulting gel material for misuse, abuse or to leach into landfills. The participant can then throw away the biodegradable solid material in the prescription bottle into the trash, as it is safe for the environment.
Eligibility Criteria
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Inclusion Criteria
* English speaking
* Residential address and phone number in the United States
* Filling a new prescription consisting of an immediate release opioid medication (i.e., immediate release morphine, oxycodone, hydromorphone, hydrocodone, tramadol; alone or in combination with acetaminophen) with ≤ 7 days' supply
Exclusion Criteria
* Non-English speaking
* Residential address and/or phone number outside the United States
* Opioid medication listed in participant's active medication list prior to prescription fill
* Filling any prescription consisting of any opioid with 8 or more days' supply
* Filling any prescription consisting of any extended-release / long-acting opioid medication (i.e., extended-release morphine, oxymorphone, oxycodone, hydromorphone, fentanyl, methadone, buprenorphine)
* Filling an opioid prescription indicated for cough or shortness of breath
18 Years
ALL
No
Sponsors
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Johns Hopkins University
OTHER
Responsible Party
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Principal Investigators
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Mark Bicket, MD
Role: PRINCIPAL_INVESTIGATOR
Johns Hopkins University
Locations
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Johns Hopkins Hospital/Johns Hopkins Outpatient Center
Baltimore, Maryland, United States
Countries
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References
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Bicket MC, Long JJ, Pronovost PJ, Alexander GC, Wu CL. Prescription Opioid Analgesics Commonly Unused After Surgery: A Systematic Review. JAMA Surg. 2017 Nov 1;152(11):1066-1071. doi: 10.1001/jamasurg.2017.0831.
Maughan BC, Hersh EV, Shofer FS, Wanner KJ, Archer E, Carrasco LR, Rhodes KV. Unused opioid analgesics and drug disposal following outpatient dental surgery: A randomized controlled trial. Drug Alcohol Depend. 2016 Nov 1;168:328-334. doi: 10.1016/j.drugalcdep.2016.08.016. Epub 2016 Sep 20.
Rose P, Sakai J, Argue R, Froehlich K, Tang R. Opioid information pamphlet increases postoperative opioid disposal rates: a before versus after quality improvement study. Can J Anaesth. 2016 Jan;63(1):31-7. doi: 10.1007/s12630-015-0502-0. Epub 2015 Oct 2.
Bicket MC, Fu D, Swarthout MD, White E, Nesbit SA, Monitto CL. Effect of Drug Disposal Kits and Fact Sheets on Elimination of Leftover Prescription Opioids: The DISPOSE Multi-Arm Randomized Controlled Trial. Pain Med. 2021 Apr 20;22(4):961-969. doi: 10.1093/pm/pnaa431.
Provided Documents
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Document Type: Study Protocol and Statistical Analysis Plan
Related Links
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Provisional Drug Overdose Death Counts
Key Substance Use and Mental Health Indicators in the United States: Results from the 2017 National Survey on Drug Use and Health
Other Identifiers
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IRB00205030
Identifier Type: -
Identifier Source: org_study_id
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