Cutaneous Leishmaniasis Diagnostic Study

NCT ID: NCT03837431

Last Updated: 2023-03-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

351 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-02-13

Study Completion Date

2023-01-31

Brief Summary

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The performance of the CL Detect Rapid test will be tested in individuals with suspected cutaneous leishmaniasis in Ethiopia using both skin slit and dental broach samples against a combined reference of microscopy and PCR. Alternative sampling methods will also be evaluated.

Detailed Description

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Cutaneous Leishmaniasis is common in Ethiopia and mainly affects the poor living in rural areas. Diagnosis of CL routinely uses invasive skin slits which are examined with microscopy, requiring trained staff and an equipped lab. A new rapid diagnostic test for CL which may be used in the field has been developed and validated in several countries where other Leishmania species are present. Less invasive tape sampling has also become available. Whether this new RDT and alternative sampling methods can be used in Ethiopia is unclear.

The performance of the CL detect Rapid Test against a combined reference (microscopy and PCR) and alternative sample collection methods will be tested in CL suspected individuals in North-West Ethiopia in a cross-sectional study.

Conditions

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Cutaneous Leishmaniases

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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CL suspicion

Individuals presenting with clinical suspicion of CL

Skin slit

Intervention Type DIAGNOSTIC_TEST

Skin slit microscopy, RDT and PCR

Dental broach

Intervention Type DIAGNOSTIC_TEST

Dental broach RDT and PCR

Tape disc

Intervention Type DIAGNOSTIC_TEST

Tape disc PCR

Interventions

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Skin slit

Skin slit microscopy, RDT and PCR

Intervention Type DIAGNOSTIC_TEST

Dental broach

Dental broach RDT and PCR

Intervention Type DIAGNOSTIC_TEST

Tape disc

Tape disc PCR

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

\- Clinical suspicion of CL

Exclusion Criteria

* ≤ 2 years of age
* Not willing or able to provide consent/assent
* CL presentation with only lesions for which skin slit samples cannot be obtained (e.g. eyelids)
* Co-morbidity with visceral leishmaniasis
* On CL treatment at time of enrollment
Minimum Eligible Age

2 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Institute of Tropical Medicine, Belgium

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Johan van Griensven, MD, PhD

Role: STUDY_CHAIR

Institute of Tropical Medicine, Antwerp, Belgium

Rezika Mohammed, MD

Role: PRINCIPAL_INVESTIGATOR

College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia

Locations

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Leishmania Research and Treatment Center, University of Gondar hospital

Gonder, , Ethiopia

Site Status

Countries

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Ethiopia

References

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van Henten S, Fikre H, Melkamu R, Dessie D, Mekonnen T, Kassa M, Bogale T, Mohammed R, Cnops L, Vogt F, Pareyn M, van Griensven J. Evaluation of the CL Detect Rapid Test in Ethiopian patients suspected for Cutaneous Leishmaniasis. PLoS Negl Trop Dis. 2022 Jan 18;16(1):e0010143. doi: 10.1371/journal.pntd.0010143. eCollection 2022 Jan.

Reference Type DERIVED
PMID: 35041672 (View on PubMed)

Other Identifiers

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1219/18

Identifier Type: -

Identifier Source: org_study_id

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